Inclusion Criteria

Patients may be eligible for this study if they:

• Are HIV-positive.
• Are at least 18 years old.
• Are on a lipid-lowering diet based on the patient's statement and have been exercising for at least 30 days before being screened for the study. Patients will be asked if they were counseled by their health care provider. The lipid-lowering diet and exercise program do not have to be prescribed by a physician.
• Have a triglyceride (TG) level of at least 200 mg/dl and low-density lipoprotein (LDL) level of at least 130 mg/dl after fasting for 8 to 12 hours.
• Have been treated with anti-HIV drugs for more than 6 months. Patients must be taking the anti-HIV drugs regularly for at least 4 weeks before they enter the study. Patients must be taking anti-HIV drugs regularly for at least 8 weeks if they have changed from taking protease inhibitor (PI) anti-HIV drugs to non-PI anti-HIV drugs. Any combination without a PI must lower the patient's HIV viral levels, as determined by the patient's physician.
• Are willing, if able to become pregnant, to use 2 reliable types of birth control while taking the study drug(s) and for 1 month after stopping the drug(s).
• Have a negative pregnancy test.
• (This reflects a change in inclusion requirements.)

Exclusion Criteria

Patients will not be eligible for the study if they:

• Have a history of heart disease.
• Have uncontrolled high blood pressure within 4 weeks of study entry.
• Have liver disease.
• Have gall bladder disease or symptoms within 3 months prior to study entry or symptoms of gallstones.
• Had surgery to remove their gallbladder within 3 months prior to study entry.
• Have diabetes requiring drug treatment or diabetes not controlled by diet.
• Have hypothyroidism (low thyroid activity).
• Are allergic or sensitive to the study drug(s) or to other lipid-lowering drugs.
• Have rhabdomyolysis (a muscle disease).
• Have taken any prescription or non-prescription lipid-lowering drug within 14 days prior to study entry or for over 24 weeks in the past.
• Take prescription lipid-lowering agents, other than those given by the study, and non-prescription lipid-lowering agents such as garlic supplements.
• Have failed previous statin or fibrate therapy (after 24 weeks of treatment) or have had side effects from these drugs.
• Receive or have received (within 14 days of study entry) treatment not approved by the FDA. Anti-HIV medications and immune-based treatments not approved by the FDA may be allowed on a case-by-case basis with the approval of the protocol team.
• Were given systemic chemotherapy for cancer other than Kaposi's sarcoma (KS).
• Were given radiation therapy within 30 days of study entry.
• Take drugs that increase risk of muscle disease (such as cyclosporine, erythromycin, itraconazole, and ketoconazole), within 14 days of study entry.
• Take or have taken levothyroxine and liothyronine for hypothyroidism.
• Take high doses of testosterone.
• Take creatine monophosphate or drugs that affect the immune system, within 30 days of study entry.
• Abuse drugs or alcohol, and the doctor thinks this may interfere with the study.
• Are pregnant or breast-feeding.
• Had a scheduled anti-HIV treatment withdrawal prior to study entry.
• (This reflects a change in exclusion requirements.)