Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women

This study has been completed.
Sponsor:
Collaborators:
Eli Lilly and Company
AstraZeneca
Information provided by (Responsible Party):
National Surgical Adjuvant Breast and Bowel Project (NSABP)
ClinicalTrials.gov Identifier:
NCT00003906
First received: November 1, 1999
Last updated: September 18, 2012
Last verified: September 2012
  Purpose

RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using raloxifene and tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells.

PURPOSE: Randomized double-blinded clinical trial to compare the effectiveness of raloxifene with that of tamoxifen in preventing breast cancer in postmenopausal women.


Condition Intervention Phase
Breast Cancer
Drug: Raloxifene
Drug: Tamoxifen
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Prevention
Official Title: Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer

Resource links provided by NLM:


Further study details as provided by National Surgical Adjuvant Breast and Bowel Project (NSABP):

Primary Outcome Measures:
  • Incidence of invasive breast cancer; superiority of one of the therapies. [ Time Frame: Time from randomization to the occurance of invasive breast cancer. ] [ Designated as safety issue: No ]

    Determine which of the following is true:

    1. compared to tamoxifen, raloxifene significantly reduces the incidence rate of invasive breast cancer;
    2. compared to raloxifene, tamoxifen significantly reduces the incidence rate of invasive breast cancer; or
    3. the statistical superiority of one of the treatments cannot be demonstrated and the choice of therapy should be based on benefit/risk considerations.


Secondary Outcome Measures:
  • Effect of the study therapies on the incidence of intraductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). [ Time Frame: Time from randomization to the occurance of DCIS or LCIS. ] [ Designated as safety issue: No ]
  • Effect of the study therapies on the incidence of endometrial cancer. [ Time Frame: Time from randomization to the occurance of endometrial cancer. ] [ Designated as safety issue: No ]
  • Effect of the study therapies on the incidence of ischemic heart disease. [ Time Frame: Time from randomization to the occurance of ischimic heart disease. ] [ Designated as safety issue: No ]
  • Effect of the study therapies on the incidence of fractures of the hip, spine, or Colles' fractures of the wrist. [ Time Frame: Time from randomization to the occurance of fractures of the hip, spine, or Colles' fractures of the wrist. ] [ Designated as safety issue: No ]
  • Effect of the study therapies on the toxicity and side effects of each therapy. [ Time Frame: Incidences of protocol defined toxicities and side effects. ] [ Designated as safety issue: Yes ]
  • Effect of the study therapies on participants' quality of life. [ Time Frame: pre-entry, every 6 months for 5 years, and then annual after 5 years following randomization. ] [ Designated as safety issue: No ]

Enrollment: 19747
Study Start Date: May 1999
Study Completion Date: August 2012
Primary Completion Date: December 2005 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Group 1
Tamoxifen and placebo
Drug: Tamoxifen
20 mg/day plus placebo for 5 years
Experimental: Group 2
Raloxifene and Placebo
Drug: Raloxifene
60 mg/day plus placebo for 5 years

Detailed Description:

OBJECTIVES:

  • Determine whether raloxifene is more or less effective than tamoxifen in significantly reducing the incidence rate of invasive breast cancer in postmenopausal women.
  • Evaluate the effects of tamoxifen and raloxifene on the incidence of intraductal carcinoma in situ, lobular carcinoma in situ, endometrial cancer, ischemic heart disease, fractures of the hip and spine, or Colles' fractures of the wrist in these participants.
  • Evaluate the toxic effects of these regimens in these participants.
  • Determine the effect of these regimens on the quality of life of these participants (at selected centers). (Quality of life evaluation closed to accrual effective 5/31/01.)

OUTLINE: This is a randomized, double-blind study. Participants are stratified by age (35 to 49 vs 50 to 59 vs over 59), race (black vs white vs other), history of lobular carcinoma in situ (yes vs no), prior hysterectomy (yes vs no), and estimated absolute risk of invasive breast cancer within 5 years (using the Gail model)(less than 2.0 vs 2.0-2.9 vs 3.0-4.9 vs 5.0 or greater). Participants are randomized to 1 of 2 arms.

  • Arm I: Participants receive oral tamoxifen plus placebo daily for 5 years.
  • Arm II: Participants receive oral raloxifene plus placebo daily for 5 years. Quality of life is assessed (at selected centers) at baseline and at 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, and 72 months. (Quality of life evaluation closed to accrual effective 5/31/01.)

Participants are followed annually after 5 years.

PROJECTED ACCRUAL: Approximately 19,000 participants will be accrued for this study within 5 years.

  Eligibility

Ages Eligible for Study:   35 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Postmenopausal women at increased risk for developing invasive breast cancer, who meet one of the following criteria:

    • At least 12 months since spontaneous menstrual bleeding
    • Prior documented hysterectomy and bilateral salpingo-oophorectomy
    • At least 55 years of age with prior hysterectomy with or without oophorectomy
    • Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of ovaries unknown with documented follicle-stimulating hormone level demonstrating elevation in postmenopausal range
  • Histologically confirmed lobular carcinoma in situ treated by local excision only OR a minimum projected 5 year probability of invasive breast cancer of at least 1.66%, using Breast Cancer Risk Assessment Profile
  • No clinical evidence of malignancy on physical exam within the past 180 days
  • No evidence of suspicious or malignant disease on bilateral mammogram within the past year
  • No bilateral or unilateral prophylactic mastectomy
  • No prior invasive breast cancer or intraductal carcinoma in situ
  • Hormone receptor status:

    • Not specified

PATIENT CHARACTERISTICS:

Age:

  • 35 and over

Sex:

  • Female

Menopausal status:

  • See Disease Characteristics

Performance status:

  • No restricted normal activity for a significant portion of each day

Life expectancy:

  • At least 10 years

Hematopoietic:

  • Granulocyte count at least 1,500/mm^3
  • Complete blood count and differential normal
  • Platelet count normal

Hepatic:

  • SGOT or SGPT normal
  • Bilirubin normal
  • Alkaline phosphatase normal

Renal:

  • Creatinine normal

Cardiovascular:

  • No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or uncontrolled hypertension
  • No deep vein thrombosis

Pulmonary:

  • No pulmonary embolus

Other:

  • No other prior malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
  • No concurrent nonmalignant disease that would preclude administration of tamoxifen or raloxifene
  • No clinical depression, psychiatric condition, or addictive disorder
  • No uncontrolled diabetes

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Not specified

Chemotherapy:

  • Not specified

Endocrine therapy:

  • At least 3 months since prior estrogen or progesterone replacement therapy, oral contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin inhibitors, or antiandrogens
  • At least 3 months since prior tamoxifen, raloxifene, or other selective estrogen-receptor modulators of less than 3 months duration
  • Concurrent Estring allowed

Radiotherapy:

  • No prior breast radiotherapy

Surgery:

  • See Disease Characteristics

Other:

  • No prior systemic adjuvant therapy for breast cancer
  • No other participation in a cancer prevention or osteoporosis prevention study involving pharmacologic intervention(s)

    • NSABP-P-1 patients who received placebo are eligible
  • No concurrent warfarin or cholestyramine
  • Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or bisphosphonates) allowed
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00003906

  Hide Study Locations
Locations
United States, Alabama
Comprehensive Cancer Institute
Huntsville, Alabama, United States, 35801
MBCCOP - Gulf Coast
Mobile, Alabama, United States, 36688
United States, Alaska
Providence Alaska Medical Center
Anchorage, Alaska, United States, 99519-6604
United States, Arizona
CCOP - Western Regional, Arizona
Phoenix, Arizona, United States, 85006-2726
CCOP - Mayo Clinic Scottsdale Oncology Program
Scottsdale, Arizona, United States, 85259-5404
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States, 85724
United States, Arkansas
Breast Associates
Fayetteville, Arkansas, United States, 72703
Surgical Associates
Fort Smith, Arkansas, United States, 72917
Northeast Arkansas Clinic
Jonesboro, Arkansas, United States, 72401
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
United States, California
Kaiser Permanente Medical Center - Anaheim/Orange County
Anaheim, California, United States, 92805
Kaiser Permanente Medical Center - Baldwin Park
Baldwin Park, California, United States, 91706
Kaiser Permanente Medical Center - Bellflower
Bellflower, California, United States, 90706
Alta Bates Comprehensive Cancer Center
Berkeley, California, United States, 94704
Providence Saint Joseph Medical Center - Burbank
Burbank, California, United States, 91505
Mills-Peninsula Health Services
Burlingame, California, United States, 94010
Enloe Cancer Center at Enloe Medical Center
Chico, California, United States, 95926
Mount Diablo Medical Center
Concord, California, United States, 94524-4110
Corona Regional Medical Center
Corona, California, United States, 92882-3400
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010-3000
Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas
Encinitas, California, United States, 92024
North Bay Cancer Center
Fairfield, California, United States, 94533
Kaiser Permanente Medical Center - Fontana
Fontana, California, United States, 92335
Crosson Cancer Center at St. Jude Medical Center
Fullerton, California, United States, 92835
Glendale Memorial Hospital Comprehensive Cancer Center
Glendale, California, United States, 91204
Oncology/Hematology Associates
Granada Hills, California, United States, 91344
Marin General Hospital Cancer Institute
Greenbrae, California, United States, 94904
Kaiser Permanente Medical Center - Harbor City
Harbor City, California, United States, 90710
Hemet Valley Medical Center
Hemet, California, United States, 92543
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, United States, 92093-0658
Valley Tumor Medical Group
Lancaster, California, United States, 93534
Loma Linda University Cancer Institute at Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Todd Cancer Institute at Long Beach Memorial Medical Center
Long Beach, California, United States, 90801-1428
Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach
Long Beach, California, United States, 90813
Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center
Los Angeles, California, United States, 90033
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States, 90033-0804
St. Vincent Medical Center - Los Angeles
Los Angeles, California, United States, 90057-1901
Kaiser Permanente Medical Center - Los Angeles
Los Angeles, California, United States, 90027
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, United States, 90095-1781
Kaiser Foundation Hospital - West Los Angeles
Los Angeles, California, United States, 90034
Mission Cancer Center at Mission Hospital
Mission Viejo, California, United States, 92691
Sutter Gould Medical Foundation
Modesto, California, United States, 95353
Leavey Cancer Center at Northridge Hospital Medical Center
Northridge, California, United States, 91328
Breast Health Center
Oceanside, California, United States, 92056
St. Joseph Hospital Regional Cancer Center - Orange
Orange, California, United States, 92868-3849
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
Orange, California, United States, 92868
Ventura Hematology - Oncology Specialists - Oxnard
Oxnard, California, United States, 93030
Comprehensive Cancer Centers of the Desert
Palm Springs, California, United States, 92262
Palo Alto Medical Foundation
Palo Alto, California, United States, 95819-5156
Kaiser Permanente Medical Group
Panorama City, California, United States, 91402
Huntington Cancer Center at Huntington Hospital
Pasadena, California, United States, 91109-7013
Wilshire Oncology Medical Group, Incorporated - Pomona
Pomona, California, United States, 91767-3021
North Valley Breast Clinic
Redding, California, United States, 96001
Kaiser Permanente Medical Center - Riverside
Riverside, California, United States, 92505
Sutter Roseville Medical Center
Roseville, California, United States, 95661
Sutter Breast Cancer Group
Sacramento, California, United States, 95819-5156
Naval Medical Center - San Diego
San Diego, California, United States, 92134-3202
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
San Diego, California, United States, 92120
UCSF Comprehensive Cancer Center
San Francisco, California, United States, 94143-0128
California Pacific Medical Center - California Campus
San Francisco, California, United States, 94118-1618
Cancer Center of Santa Barbara
Santa Barbara, California, United States, 93105
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, United States, 95403
Stanford Cancer Center at Stanford University Medical Center
Stanford, California, United States, 94305-5408
Torrance Memorial Medical Center
Torrance, California, United States, 90505
Santa Clarita Valley Cancer Center - UCLA
Valencia, California, United States, 91355
Kaiser Permanente Medical Center - Vallejo
Vallejo, California, United States, 94589
Kaiser Permanente Medical Cener - Woodland Hills
Woodland Hills, California, United States, 91365-4084
United States, Colorado
Penrose Cancer Center
Colorado Springs, Colorado, United States, 80933
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, United States, 80209-5031
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, United States, 81004
United States, Connecticut
University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center
Farmington, Connecticut, United States, 06360-7106
Hartford Hospital
Hartford, Connecticut, United States, 06102-5037
St. Francis Hospital and Medical Center
Hartford, Connecticut, United States, 06105
Manchester Memorial Hospital
Manchester, Connecticut, United States, 06040-4188
Midstate Medical Center
Meriden, Connecticut, United States, 06451
New Britain General Hospital
New Britain, Connecticut, United States, 06050
Hospital of St. Raphael
New Haven, Connecticut, United States, 06511
Yale Comprehensive Cancer Center
New Haven, Connecticut, United States, 06520-8028
Lawrence and Memorial Hospital
New London, Connecticut, United States, 06320
Eastern Connecticut Hematology and Oncology Associates
Norwich,, Connecticut, United States, 06360
Hematology Oncology, P.C.
Stamford, Connecticut, United States, 06902
Northwestern Connecticut Oncology-Hematology Associates
Torrington, Connecticut, United States, 06790
Windham Community Memorial Hospital
Williamantic, Connecticut, United States, 06226
United States, Delaware
Beebe Medical Center
Lewes, Delaware, United States, 19958
Nanticoke Memorial Hospital
Seaford, Delaware, United States, 19973
CCOP - Christiana Care Health Services
Wilmington, Delaware, United States, 19899
United States, District of Columbia
Lombardi Cancer Center at Georgetown University Medical Center
Washington, District of Columbia, United States, 20007
Providence Hospital
Washington, District of Columbia, United States, 20017
Washington Hospital Center
Washington, District of Columbia, United States, 20010
United States, Florida
JFK Medical Center
Atlantis, Florida, United States, 33462
Baptist Regional Cancer Institute - Jacksonville
Jacksonville, Florida, United States, 32207
St. Vincent's Medical Center
Jacksonville, Florida, United States, 32203
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, United States, 33458
Watson Clinic
Lakeland, Florida, United States, 33804-5000
Lakeland Regional Cancer Center at Lakeland Regional Medical Center
Lakeland, Florida, United States, 33804
University of Miami Sylvester Cancer Center
Miami, Florida, United States, 33136
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
MD Anderson Cancer Center Orlando
Orlando, Florida, United States, 32806
Florida Hospital Medical Center
Orlando, Florida, United States, 32803-1273
West Florida Regional Medical Center
Pensacola, Florida, United States, 32514-6088
Cancer Research Network Inc.
Plantation, Florida, United States, 33324
Clinical Research Center of South Florida
Stuart, Florida, United States, 34996
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612-9497
Palm Beach Cancer Institute
West Palm Beach, Florida, United States, 33401
United States, Georgia
CCOP - Atlanta Regional
Atlanta, Georgia, United States, 30342-1701
Medical College of Georgia
Augusta, Georgia, United States, 30912
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, United States, 31403-3089
Cancer Care and Research Pavilion at St. Joseph's/Candler
Savannah, Georgia, United States, 31405-6013
United States, Hawaii
MBCCOP - Hawaii
Honolulu, Hawaii, United States, 96813
United States, Idaho
North Idaho Cancer Center
Coeur d'Alene, Idaho, United States, 83814
United States, Illinois
Northwest Community Hospital
Arlington Heights, Illinois, United States, 60005
Rush Copley Medical Center
Aurora, Illinois, United States, 60504-4206
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Our Lady of the Resurrection Medical Center
Chicago, Illinois, United States, 60634
Creticos Cancer Center at Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States, 60657
MBCCOP - University of Illinois at Chicago
Chicago, Illinois, United States, 60612-7323
Resurrection Medical Center
Chicago, Illinois, United States, 60631
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States, 60611-3013
Rush Cancer Institute at Rush University Medical Center
Chicago, Illinois, United States, 60612
John H. Stroger, Jr. Hospital of Cook County
Chicago, Illinois, United States, 60612-9985
University of Chicago Cancer Research Center
Chicago, Illinois, United States, 60637-1470
CCOP - Central Illinois
Decatur, Illinois, United States, 62526
Sherman Hospital
Elgin, Illinois, United States, 60120-2198
CCOP - Evanston
Evanston, Illinois, United States, 60201
St. Francis Hospital
Evanston, Illinois, United States, 60202
Ingalls Memorial Hospital
Harvey, Illinois, United States, 60426
Advocate South Suburban Hospital
Hazel Crest, Illinois, United States, 60429
Evanston Northwestern Health Care - Highland Park Hospital
Highland Park, Illinois, United States, 60035-2497
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, United States, 60521
Joliet Oncology Hematology Associates, Limited - Joliet
Joliet, Illinois, United States, 60435
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, United States, 60153
Edward Hospital Cancer Center
Naperville, Illinois, United States, 60540-7499
Mid-Illinois Hematology-Oncology Associates
Normal, Illinois, United States, 61761
Advocate Christ Medical Center
Oak Lawn, Illinois, United States, 60453
Saint James Hospital and Health Centers Comprehensive Cancer Institute
Olympia Fields, Illinois, United States, 60461
Lutheran General Cancer Care Center
Park Ridge, Illinois, United States, 60068
CCOP - Illinois Oncology Research Association
Peoria, Illinois, United States, 61602
Trinity Medical Center - West
Rock Island, Illinois, United States, 61201
Saint Anthony Medical Center
Rockford, Illinois, United States, 61108
Rockford Clinic
Rockford, Illinois, United States, 61103
Swedish-American Regional Cancer Center
Rockford, Illinois, United States, 61104-2315
Edward H. Kaplan MD and Associates
Skokie, Illinois, United States, 60076
St. John's Hospital
Springfield, Illinois, United States, 62769
Memorial Medical Center
Springfield, Illinois, United States, 62781
CCOP - Carle Cancer Center
Urbana, Illinois, United States, 61801
United States, Indiana
Center for Cancer Care at Goshen Health System
Goshen, Indiana, United States, 46526
Indiana Regional Cancer Center
Indianapolis, Indiana, United States, 46256
St. Vincent Hospital and Health Care Center
Indianapolis, Indiana, United States, 46260
Indiana Community Cancer Care, Incorporated
Indianapolis, Indiana, United States, 46202
Methodist Cancer Center at Methodist Hospital
Indianapolis, Indiana, United States, 46206-1367
Oncology Institute of Greater Lafayette
Lafayette, Indiana, United States, 47904
Saint Anthony Memorial Health Centers
Michigan City, Indiana, United States, 46360
Ball Memorial Hospital Cancer Center
Muncie, Indiana, United States, 47303-3499
Community Hospital
Munster, Indiana, United States, 46321
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, United States, 46601
United States, Iowa
McFarland Clinic, P.C.
Ames, Iowa, United States, 50010
CCOP - Cedar Rapids Oncology Project
Cedar Rapids, Iowa, United States, 52403-1206
Medical Associates
Clinton, Iowa, United States, 52732-5031
Jennie Edmundson Memorial Hospital
Council Bluffs, Iowa, United States, 51503
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, United States, 52803
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, United States, 50309-1016
Wendt Regional Cancer Center of Finley Hospital
Dubuque, Iowa, United States, 52001
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, United States, 52242-1009
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City, Iowa, United States, 50401
Ottumwa Regional Health Center
Ottumwa, Iowa, United States, 52501
Siouxland Hematology-Oncology
Sioux City, Iowa, United States, 51101-1733
Cedar Valley Medical Specialists, P.C.
Waterloo, Iowa, United States, 50701
United States, Kansas
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, United States, 66160-7357
CCOP - Wichita
Wichita, Kansas, United States, 67214-3882
United States, Kentucky
King's Daughters Medical Center
Ashland, Kentucky, United States, 41101
St. Elizabeth Medical Center
Edgewood, Kentucky, United States, 41017
HCA Kings Daughters Memorial Hospital
Frankfort, Kentucky, United States, 40601
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, United States, 40536-0093
Central Baptist Hospital
Lexington, Kentucky, United States, 40503
James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, United States, 40202
Baptist Hospital East - Louisville
Louisville, Kentucky, United States, 40207
Norton Healthcare Cancer Center
Louisville, Kentucky, United States, 40202-5070
United States, Louisiana
Baton Rouge General Medical Center
Baton Rouge, Louisiana, United States, 70821-2511
Ochsner Clinic of Baton Rouge
Baton Rouge, Louisiana, United States, 70809
Cancer Care Specialists
Houma, Louisiana, United States, 70360
CCOP - Ochsner
New Orleans, Louisiana, United States, 70121
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, United States, 70112
Tulane Cancer Center at Tulane University Hospital and Clinic
New Orleans, Louisiana, United States, 70112
Cancer Treatment Center at Christus Schumpert St. Mary Place
Shreveport, Louisiana, United States, 71101
United States, Maine
Eastern Maine Medical Center
Bangor, Maine, United States, 04401
Goodall Hospital
Sanford, Maine, United States, 04073
Maine Center for Cancer Medicine and Blood Disorders - Scarborough
Scarborough, Maine, United States, 04074
United States, Maryland
Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States, 21231-2410
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, United States, 21201
Greater Baltimore Medical Center and Cancer Center
Baltimore, Maryland, United States, 21204
Franklin Square Hospital Center
Baltimore, Maryland, United States, 21237
Suburban Hospital
Bethesda, Maryland, United States, 20814
Frederick Memorial Hospital Regional Cancer Therapy Center
Frederick, Maryland, United States, 21701
United States, Massachusetts
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02115
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States, 02114
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Cancer Research Center at Boston Medical Center
Boston, Massachusetts, United States, 02118
Harvard Vanguard Medical Associates - Kenmore
Boston, Massachusetts, United States, 02215
Lahey Clinic Medical Center - Burlington
Burlington, Massachusetts, United States, 01805
Saint Anne's Hospital
Fall River, Massachusetts, United States, 02721
Caritas Norwood Hospital
Norfolk, Massachusetts, United States, 02062
NSMC Cancer Center
Peabody, Massachusetts, United States, 01960
Berkshire Physicians and Surgeons, P.C.
Pittsfield, Massachusetts, United States, 01201
Jordan Hospital Club Cancer Center
Plymouth, Massachusetts, United States, 02360
Baystate Regional Cancer Program at Baystate Medical Center
Springfield, Massachusetts, United States, 01199
University of Massachusetts Memorial Medical Center - University Campus
Worcester, Massachusetts, United States, 01655
United States, Michigan
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, United States, 49221
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, United States, 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109-0752
Battle Creek Health System
Battle Creek, Michigan, United States, 49016
Bay Diagnostic Center for Women
Bay City, Michigan, United States, 48708
Community Health Center of Branch County
Coldwater, Michigan, United States, 49036
Oakwood Hospital and Medical Center
Dearborn, Michigan, United States, 48123-2500
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, United States, 48202
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States, 48201-1379
St. John Hospital and Medical Center
Detroit, Michigan, United States, 48236
Flint Hematology Oncology
Flint, Michigan, United States, 48532
Hurley Medical Center
Flint, Michigan, United States, 48503
Genesys Regional Medical Center
Grand Blanc, Michigan, United States, 48439-8066
CCOP - Grand Rapids
Grand Rapids, Michigan, United States, 49503
Holland Community Hospital
Holland, Michigan, United States, 49423
Center for Hematology/Oncology
Jackson, Michigan, United States, 49201
CCOP - Kalamazoo
Kalamazoo, Michigan, United States, 49007-3731
Michigan State University Department of Surgery
Lansing, Michigan, United States, 48912
Lapeer Regional Hospital
Lapeer, Michigan, United States, 48446
Marquette General Hospital
Marquette, Michigan, United States, 49855
Mercy Memorial Hospital, Corporation
Monroe, Michigan, United States, 48161-0067
Community Cancer Care Specialist
Mount Clemens, Michigan, United States, 48043
Memorial Healthcare
Owosso, Michigan, United States, 48867
Blue Water Oncology PC, Port Huron
Port Huron, Michigan, United States, 48060
CCOP - Beaumont
Royal Oak, Michigan, United States, 48073-6769
Saint Mary's Seton Cancer Institute
Saginaw, Michigan, United States, 48601
Providence Cancer Institute at Providence Hospital
Southfield, Michigan, United States, 48075-9975
Munson Medical Center
Traverse City, Michigan, United States, 49684
St. John Macomb Hospital
Warren, Michigan, United States, 48093-3494
United States, Minnesota
St. Luke's Medical Clinic
Duluth, Minnesota, United States, 55805
CCOP - Duluth
Duluth, Minnesota, United States, 55805
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55415
Minnesota Cooperative Group Program
Minneapolis, Minnesota, United States, 55407
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, United States, 55416
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
United States, Mississippi
Coast Oncology/Hematology, P.L.L.C.
Biloxi, Mississippi, United States, 39530-4239
Mid Delta Family Practice
Cleveland, Mississippi, United States, 38732
Hattiesburg Clinic, P.A.
Hattiesburg, Mississippi, United States, 39401
Jackson Oncology Associates, PLLC
Jackson, Mississippi, United States, 39202
Keesler Medical Center - Keesler Air Force Base
Keesler AFB, Mississippi, United States, 39534-2576
North Mississippi Hematology and Oncology Associates, Limited
Tupelo, Mississippi, United States, 38801
United States, Missouri
Saint Luke's Hospital
Chesterfield, Missouri, United States, 63017
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, United States, 65203
St. John's Regional Medical Center
Joplin, Missouri, United States, 64804
Freeman Cancer Institute at Freeman Health System
Joplin, Missouri, United States, 64803-2644
CCOP - Kansas City
Kansas City, Missouri, United States, 64131
Phelps County Regional Medical Center
Rolla, Missouri, United States, 65401
CCOP - St. Louis-Cape Girardeau
Saint Louis, Missouri, United States, 63141
Midwest Hematology Oncology Group, Inc.
Saint Louis, Missouri, United States, 63109
Missouri Baptist Cancer Center
Saint Louis, Missouri, United States, 63131
Siteman Cancer Center
Saint Louis, Missouri, United States, 63110
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, United States, 65807
St. John's Regional Health Center
Springfield, Missouri, United States, 65804
Missouri Cancer Care, P.C. - St. Charles
St. Charles, Missouri, United States, 63301
Ozarks Medical Center
West Plains, Missouri, United States, 65775
United States, Montana
CCOP - Montana Cancer Consortium
Billings, Montana, United States, 59101
Montana Cancer Institute - Benefis Healthcare
Great Falls, Montana, United States, 59405
Kalispell Regional Medical Center
Kalispell, Montana, United States, 59901
United States, Nebraska
Saint Francis Medical Center
Grand Island, Nebraska, United States, 68802
Cancer Center at the Good Samaritan Health Systems
Kearney, Nebraska, United States, 68848-1990
Cancer Resource Center - Lincoln
Lincoln, Nebraska, United States, 68510-4844
Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Alegent Health - Immanuel Medical Center
Omaha, Nebraska, United States, 68122
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
Omaha, Nebraska, United States, 68114
Creighton University Medical Center
Omaha, Nebraska, United States, 68131-2197
United States, Nevada
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, United States, 89106
United States, New Hampshire
New Hampshire Oncology-Hematology, PA - Hooksett
Hooksett, New Hampshire, United States, 03106
Southern New Hampshire Medical Center
Nashua, New Hampshire, United States, 03061
United States, New Jersey
Cooper Cancer Institute
Camden, New Jersey, United States, 08103
Englewood Hospital and Medical Center
Englewood, New Jersey, United States, 07631
Hunterdon Regional Cancer Center
Flemington, New Jersey, United States, 08822
CCOP - Northern New Jersey
Hackensack, New Jersey, United States, 07601
St. Barnabas Medical Center
Livingston, New Jersey, United States, 07039
Monmouth Medical Center
Long Branch, New Jersey, United States, 07740-6395
South Jersey Regional Cancer Center
Millville, New Jersey, United States, 08332
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital
Mount Holly, New Jersey, United States, 08060
Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Warren Hospital
Phillipsburg, New Jersey, United States, 08865
Atlantic City Medical Center
Pomona, New Jersey, United States, 08240
Booker Cancer Center at Riverview Medical Center
Red Bank, New Jersey, United States, 07701
Valley Hospital
Ridgewood, New Jersey, United States, 07450
Somerset Medical Center
Somerville, New Jersey, United States, 08876
Community Medical Center
Toms River, New Jersey, United States, 08755
Capital Health System at Mercer
Trenton, New Jersey, United States, 08607
Underwood Memorial Hospital
Woodbury, New Jersey, United States, 08096
United States, New Mexico
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, United States, 87131
Lovelace Medical Center at Lovelace Sandia Health System
Albuquerque, New Mexico, United States, 87108
New Mexico Oncology-Hematology Consultants, Limited
Albuquerque, New Mexico, United States, 87109
Hematology-Oncology Associates, PC
Albuquerque, New Mexico, United States, 87102
New Mexico Cancer Care Associates
Santa Fe, New Mexico, United States, 87505-7670
United States, New York
New York Oncology Hematology, P.C. - Albany Regional Cancer Center
Albany, New York, United States, 12208
Comprehensive Cancer Center at Our Lady of Mercy Medical Center
Bronx, New York, United States, 10466
Albert Einstein Clinical Cancer Center
Bronx, New York, United States, 10461
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263-0001
Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
Cooperstown, New York, United States, 13326-1394
Charles R. Wood Foundation Cancer Center at Glens Falls Hospital
Glens Falls, New York, United States, 12801
Queens Cancer Center of Queens Hospital
Jamaica, New York, United States, 11432
New York Oncology Hematology, P.C. - Latham
Latham, New York, United States, 12110-0610
CCOP - North Shore University Hospital
Manhasset, New York, United States, 11030
NYU School of Medicine's Kaplan Comprehensive Cancer Center
New York, New York, United States, 10016
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
Saint Vincent Catholic Medical Center of New York
New York, New York, United States, 10011
Herbert Irving Comprehensive Cancer Center at Columbia University
New York, New York, United States, 10032
Vassar Brothers Medical Center
Poughkeepsie, New York, United States, 12601
St. Francis Hospital and Health Centers
Poughkeepsie, New York, United States, 12601
Genesee Surgical Associates
Rochester, New York, United States, 14607
Gynecologic Oncology Associates
Rochester, New York, United States, 14620
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States, 14642
University Hospital - Stony Brook
Stony Brook, New York, United States, 11794-8174
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, United States, 13217
University Hospital at State University of New York - Upstate Medical University
Syracuse, New York, United States, 13210
United States, North Carolina
Mission Hospitals
Asheville, North Carolina, United States, 28801
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, United States, 27599-7295
Blumenthal Cancer Center at Carolinas Medical Center
Charlotte, North Carolina, United States, 28232-2861
Presbyterian Healthcare
Charlotte, North Carolina, United States, 28233-3549
Duke Comprehensive Cancer Center
Durham, North Carolina, United States, 27710
Cape Fear Valley Health System
Fayetteville, North Carolina, United States, 28302-2000
Gaston Hematology and Oncology
Gastonia, North Carolina, United States, 28054
Southeastern Medical Oncology Center
Goldsboro, North Carolina, United States, 27534
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
Greensboro, North Carolina, United States, 27403-1199
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina
Greenville, North Carolina, United States, 27858-4354
Pardee Memorial Hospital
Hendersonville, North Carolina, United States, 28791
Cornerstone Surgery
High Point, North Carolina, United States, 27262
Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center
Raleigh, North Carolina, United States, 27607
Cancer Center at Iredell Memorial Hospital
Statesville, North Carolina, United States, 28687-1828
New Hanover Regional Medical Center
Wilmington, North Carolina, United States, 28402-9000
Forsyth Medical Center
Winston-Salem, North Carolina, United States, 27103
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, United States, 27157-1082
CCOP - Southeast Cancer Control Consortium
Winston-Salem, North Carolina, United States, 27104-4241
United States, North Dakota
Quain & Ramstad Clinic
Bismarck, North Dakota, United States, 58501
CCOP - Merit Care Hospital
Fargo, North Dakota, United States, 58122
United States, Ohio
Akron General Medical Center
Akron, Ohio, United States, 44302
Mercy Medical Center
Canton, Ohio, United States, 44708
Aultman Hospital Cancer Center at Aultman Health Foundation
Canton, Ohio, United States, 44710
Bethesda North Hospital
Cincinnati, Ohio, United States, 45242
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, United States, 45267-0502
Cancer Center at Christ Hospital
Cincinnati, Ohio, United States, 45219
Kaiser Permanente
Cleveland, Ohio, United States, 44120
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States, 44195
Ireland Cancer Center
Cleveland, Ohio, United States, 44106-5065
Fairview Hospital
Cleveland, Ohio, United States, 44111
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, United States, 43210-1240
CCOP - Columbus
Columbus, Ohio, United States, 43206
Blanchard Valley Medical Associates
Findlay, Ohio, United States, 45840
Fremont Memorial Hospital
Fremont, Ohio, United States, 43420
Cleveland Clinic Cancer Center
Independence, Ohio, United States, 44131
CCOP - Dayton
Kettering, Ohio, United States, 45429
Lima Memorial Hospital
Lima, Ohio, United States, 45804
St. Luke's Hospital
Maumee, Ohio, United States, 43537
Parma Community General Hospital
Parma, Ohio, United States, 44129
Firelands Regional Medical Center
Sandusky, Ohio, United States, 44870
Flower Hospital - ProMedica Health System
Sylvania, Ohio, United States, 43560
Medical College of Ohio Cancer Institute
Toledo, Ohio, United States, 43614-0008
CCOP - Toledo Community Hospital
Toledo, Ohio, United States, 43623
St. Vincent Mercy Medical Center
Toledo, Ohio, United States, 43608
St. Charles Hospital
Toledo, Ohio, United States, 43616
Toledo Clinic, Incorporated
Toledo, Ohio, United States, 43623
Toledo Hospital
Toledo, Ohio, United States, 43606
Cleveland Clinic Health System STAR BCPT
Warrensville Heights, Ohio, United States, 44122
Fulton County Health Center
Wauseon, Ohio, United States, 43567
United States, Oklahoma
Muskogee Regional Medical Center
Muskogee, Oklahoma, United States, 74401
Oklahoma University Medical Center at University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73190
Frank C. Love Cancer Institute at St. Anthony Hospital
Oklahoma City, Oklahoma, United States, 73101
Mercy Health Center
Oklahoma City, Oklahoma, United States, 73120
Central Oklahoma Cancer Center at INTEGRIS Southwest Medical Center
Oklahoma City, Oklahoma, United States, 73109
CCOP - Oklahoma
Tulsa, Oklahoma, United States, 74136
St. John Health System
Tulsa, Oklahoma, United States, 74104
United States, Oregon
St. Charles Medical Center
Bend, Oregon, United States, 97701
Kaiser Permanente Center for Health Research
Portland, Oregon, United States, 97227-1098
CCOP - Columbia River Oncology Program
Portland, Oregon, United States, 97213
Cancer Institute at Oregon Health and Science University
Portland, Oregon, United States, 97201-3098
United States, Pennsylvania
Abington Memorial Hospital
Abington, Pennsylvania, United States, 19001
Sacred Heart Hospital
Allentown, Pennsylvania, United States, 18102
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
Allentown, Pennsylvania, United States, 18103
Bon Secours-Holy Family Health System
Altoona, Pennsylvania, United States, 16602
St. Luke's Hospital Cancer Center
Bethlehem, Pennsylvania, United States, 18015
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, United States, 19010
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822-2001
Mercy Fitzgerald Hospital
Darby, Pennsylvania, United States, 19023
Doylestown Hospital
Doylestown, Pennsylvania, United States, 18901
Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, United States, 19026
Easton Hospital
Easton, Pennsylvania, United States, 18042
Ephrata Community Hopital
Ephrata, Pennsylvania, United States, 17522-1002
Regional Cancer Center - Erie
Erie, Pennsylvania, United States, 16505
Pinnacle Health Regional Cancer Center at Pinnacle Health System
Harrisburg, Pennsylvania, United States, 17105-8700
Mercy Community Hospital
Havertown, Pennsylvania, United States, 19083
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Lancaster General Hospital
Lancaster, Pennsylvania, United States, 17604-3555
Saint Mary Regional Cancer Center
Langhorne, Pennsylvania, United States, 19047
Riddle Memorial Hospital
Media, Pennsylvania, United States, 19063
Cancer Center at Paoli Memorial Hospital
Paoli, Pennsylvania, United States, 19301-1792
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, United States, 19141
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, United States, 19107-5541
Mercy Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19143
Chestnut Hill Healthcare
Philadelphia, Pennsylvania, United States, 19118
Fox Chase - Temple Cancer Center
Philadelphia, Pennsylvania, United States, 19140
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111
Frankford Hospital
Philadelphia, Pennsylvania, United States, 19114
Abramson Cancer Center at University of Pennsylvania Medical Center
Philadelphia, Pennsylvania, United States, 19104-4283
Pennsylvania Oncology Hematology Associates
Philadelphia, Pennsylvania, United States, 19107
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212-4772
Hillman Cancer Center at University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, United States, 15213-3489
Pottstown Memorial Regional Cancer Center
Pottstown, Pennsylvania, United States, 19464
Reading Hospital and Medical Center
Reading, Pennsylvania, United States, 19612-6052
Grand View Hospital
Sellersville, Pennsylvania, United States, 18960
Crozer-Chester Medical Center
Upland, Pennsylvania, United States, 19013
Chester County Hospital
West Chester, Pennsylvania, United States, 19380
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, United States, 19096
Wellspan Health - York Cancer Center
York, Pennsylvania, United States, 17403
United States, Rhode Island
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
United States, South Carolina
AnMed Health
Anderson, South Carolina, United States, 29621
Roper St. Francis Healthcare - Roper Hospital
Charleston, South Carolina, United States, 29401
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Palmetto Richland Memorial Hospital
Columbia, South Carolina, United States, 29203
McLeod Regional Medical Center
Florence, South Carolina, United States, 29501
Cancer Centers of the Carolinas - Eastside
Greenville, South Carolina, United States, 29601
CCOP - Upstate Carolina
Spartanburg, South Carolina, United States, 29303
United States, South Dakota
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57701
CCOP - Sioux Community Cancer Consortium
Sioux Falls, South Dakota, United States, 57104
United States, Tennessee
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee, United States, 37662
Thompson Cancer Survival Center
Knoxville, Tennessee, United States, 37916
U.T. Cancer Institute at University of Tennessee Medical Center
Knoxville, Tennessee, United States, 37920-2911
Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis
Memphis, Tennessee, United States, 38117
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center
Nashville, Tennessee, United States, 37232-6838
MBCCOP - Meharry Medical College - Nashville
Nashville, Tennessee, United States, 37208-3599
United States, Texas
Hendrick Cancer Center
Abilene, Texas, United States, 79601-2316
Harrington Cancer Center
Amarillo, Texas, United States, 79106
Julie and Ben Rogers Cancer Center
Beaumont, Texas, United States, 77701
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, United States, 75235-9154
Charles A. Sammons Cancer Center
Dallas, Texas, United States, 75246
Methodist Dallas Medical Center
Dallas, Texas, United States, 75265-5999
Presbyterian Hospital of Dallas
Dallas, Texas, United States, 75231
Providence Memorial Hospital
El Paso, Texas, United States, 79902
Harris Methodist Fort Worth
Fort Worth, Texas, United States, 76104
Baylor College of Medicine
Houston, Texas, United States, 77030
University of Texas - MD Anderson Cancer Center
Houston, Texas, United States, 77030-4009
Texas Cancer Institute at St. Luke's Episcopal Hospital
Houston, Texas, United States, 77030
Baylor Medical Center at Garland
Irving, Texas, United States, 75061
Wilford Hall Medical Center
Lackland Air Force Base, Texas, United States, 78236-5300
Sanchez Cancer Center
Laredo, Texas, United States, 78041
Southwest Cancer and Research Center at University Medical Center
Lubbock, Texas, United States, 79415
Joe Arrington Cancer Research and Treatment Center
Lubbock, Texas, United States, 79410-1894
Memorial Health System of East Texas
Lufkin, Texas, United States, 75902
Baylor/Richardson Cancer Center
Richardson, Texas, United States, 75080
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78284-7811
CCOP - Scott and White Hospital
Temple, Texas, United States, 76508
University of Texas Health Center at Tyler
Tyler, Texas, United States, 75708
United States, Utah
Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84112
United States, Vermont
Southwestern Vermont Regional Cancer Center
Bennington, Vermont, United States, 05201
Green Mountain Oncology Group
Bennington, Vermont, United States, 05201
Mountainview Medical
Berlin, Vermont, United States, 05602
Vermont Cancer Center at University of Vermont
Burlington, Vermont, United States, 05401-3498
Community Cancer Center at Rutland Regional Medical Center
Rutland, Vermont, United States, 05701
United States, Virginia
Martha Jefferson Hospital
Charlottesville, Virginia, United States, 22901
Danville Hematology and Oncology, Incorporated
Danville, Virginia, United States, 24541
Cancer Center of the Piedmont, Inc.
Danville, Virginia, United States, 24541
Virginia Oncology Associates - Newport News
Newport News, Virginia, United States, 23606
Henrico Doctors' Hospital - Parham Campus
Richmond, Virginia, United States, 23229
MBCCOP - Massey Cancer Center
Richmond, Virginia, United States, 23298-0037
Oncology and Hematology Associates of Southwest Virginia, Inc.
Roanoke, Virginia, United States, 24014
United States, Washington
St. Joseph Hospital Community Cancer Center
Bellingham, Washington, United States, 98225
Olympic Hematology and Oncology
Bremerton, Washington, United States, 98310
Flynn Cancer Center at Providence Everett Medical Center - Pacific Campus
Everett, Washington, United States, 98258-0000
CCOP - Virginia Mason Research Center
Seattle, Washington, United States, 98101
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109-1024
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, United States, 98104
Rockwood Clinic P.S.
Spokane, Washington, United States, 99220
Cancer Care Northwest - Spokane North
Spokane, Washington, United States, 99207
CCOP - Northwest
Tacoma, Washington, United States, 98405-0986
Yakima Regional Cancer Care Center
Yakima, Washington, United States, 89802
United States, West Virginia
David Lee Cancer Center at Charleston Area Medical Center
Charleston, West Virginia, United States, 25304-1297
Camden-Clark Memorial Hospital
Parkersburg, West Virginia, United States, 26102
United States, Wisconsin
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States, 53792-6164
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, United States, 54449
Medical College of Wisconsin Cancer Center
Milwaukee, Wisconsin, United States, 53226
Aurora Sinai Medical Center
Milwaukee, Wisconsin, United States, 53201-0342
Oncology Alliance, S.C.
Milwaukee, Wisconsin, United States, 53215
Waukesha Memorial Hospital Regional Cancer Center
Waukesha, Wisconsin, United States, 53188
UW Cancer Center Wausau Hospital
Wausau, Wisconsin, United States, 54401
Canada, Alberta
Tom Baker Cancer Center - Calgary
Calgary, Alberta, Canada, T2N 4N2
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Canada, British Columbia
University Hospital - U.B.C. Site
Vancouver, British Columbia, Canada, V6T 2B5
Canada, Manitoba
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Canada, Ontario
Familial Oncology Program
Kingston, Ontario, Canada, K7L 5P9
Credit Valley Hospital
Mississauga, Ontario, Canada, L5M 2N1
North York General Hospital, Ontario
North York, Ontario, Canada, M2E 1K1
Ottawa Regional Cancer Centre
Ottawa, Ontario, Canada, K1H 1C4
Northwestern Ontario Regional Cancer Care
Thunder Bay, Ontario, Canada, P7A 7T1
St. Michael's Hospital - Toronto
Toronto, Ontario, Canada, M5B 1W8
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Toronto Sunnybrook Regional Cancer Centre
Toronto, Ontario, Canada, M4N 3M5
Women's College Ambulatory Care Center, Sunnybrook and Women's College Health Science Center
Toronto, Ontario, Canada, M5S 1B6
Canada, Quebec
CHUS-Hopital Fleurimont
Fleurimont, Quebec, Canada, J1H 5N4
Hopital Charles Lemoyne
Greenfield Park, Quebec, Canada, J4V 2H1
Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2L-4M1
Jewish General Hospital - Montreal
Montreal, Quebec, Canada, H3T 1E2
Montreal General Hospital
Montreal, Quebec, Canada, H3G 1A4
Ville Marie Breast Center
Montreal, Quebec, Canada, H3G 1L5
Royal Victoria Hospital - Montreal
Montreal, Quebec, Canada, H3A 1A1
Hopital du Saint-Sacrement, Quebec
Quebec City, Quebec, Canada, G1S 4L8
Centre Universitaire de Sante de L'Estrie
Sherbrooke, Quebec, Canada, J1H 5N4
Canada, Saskatchewan
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada, S7N 4H4
Puerto Rico
MBCCOP - San Juan
San Juan, Puerto Rico, 00927-5800
Sponsors and Collaborators
National Surgical Adjuvant Breast and Bowel Project (NSABP)
Eli Lilly and Company
AstraZeneca
Investigators
Study Chair: Norman Wolmark, MD NSABP Foundation, Inc.
  More Information

Additional Information:
Publications:
Ganz PA, Land SR, Wickerham DL, et al.: The Study of Tamoxifen and Raloxifene (STAR): Change in patient-reported outcomes (PROs) after the end of treatment. [Abstract] J Clin Oncol 25 (Suppl 18): A-1506, 2007.
Ganz PA, Land SR, Wickerham DL, et al.: The study of tamoxifen and raloxifene (STAR): first report of patient-reported outcomes (PROs) from the NSABP P-2 breast cancer prevention study. [Abstract] J Clin Oncol 24 (Suppl 18): A-LBA561, 2006.
Vogel VG, Costantino JP, Wickerham DL, et al.: The effects of tamoxifen versus raloxifene on the risk of developing noninvasive breast cancer in the NSABP study of tamoxifen and raloxifene (STAR) P-2 trial. [Abstract] Breast Cancer Res Treat 100 (Suppl 1): A-33, S16, 2006.
Cronin WM, Cecchini RS, Wickerham DL, et al.: Factors associated with participant adherence in the NSABP Study of Tamoxifen and Raloxifene (STAR). [Abstract] J Clin Oncol 26 (Suppl 15): A-6518, 2008.

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: National Surgical Adjuvant Breast and Bowel Project (NSABP)
ClinicalTrials.gov Identifier: NCT00003906     History of Changes
Other Study ID Numbers: NSABP P-2, CDR0000067081
Study First Received: November 1, 1999
Last Updated: September 18, 2012
Health Authority: United States: Food and Drug Administration
United States: Federal Government
United States: Institutional Review Board
Canada: Ethics Review Committee
Canada: Health Canada

Keywords provided by National Surgical Adjuvant Breast and Bowel Project (NSABP):
breast cancer

Additional relevant MeSH terms:
Breast Neoplasms
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases
Tamoxifen
Raloxifene
Estrogen Antagonists
Estrogen Receptor Modulators
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Therapeutic Uses
Selective Estrogen Receptor Modulators
Bone Density Conservation Agents

ClinicalTrials.gov processed this record on August 28, 2014