Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma - Full Text View

Sponsor:	European Organization for Research and Treatment of Cancer
Information provided by:	National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:	NCT00003728

Purpose

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy plus steroid therapy is more effective for acute lymphoblastic leukemia or lymphoblastic non-Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of combination chemotherapy plus steroid therapy in treating children who have acute lymphoblastic leukemia or lymphoblastic non-Hodgkin's lymphoma.

Condition	Intervention	Phase
Leukemia Lymphoma	Drug: asparaginase Drug: cyclophosphamide Drug: cytarabine Drug: daunorubicin hydrochloride Drug: dexamethasone Drug: doxorubicin hydrochloride Drug: etoposide Drug: leucovorin calcium Drug: mercaptopurine Drug: methotrexate Drug: methylprednisolone Drug: mitoxantrone hydrochloride Drug: prednisolone Drug: therapeutic hydrocortisone Drug: thioguanine Drug: vincristine sulfate Drug: vindesine Procedure: allogeneic bone marrow transplantation Procedure: peripheral blood stem cell transplantation	Phase III

Study Type:	Interventional
Study Design:	Treatment, Randomized, Active Control
Official Title:	The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood

Resource links provided by NLM:

MedlinePlus related topics: Bone Marrow Transplantation Cancer Leukemia, Childhood Lymphoma

Drug Information available for: Dexamethasone Hydrocortisone acetate Cyclophosphamide Hydrocortisone Prednisolone 6-Mercaptopurine Prednisolone acetate Depo-medrol Vincristine Leucovorin Methotrexate Cytarabine hydrochloride Daunorubicin Doxorubicin Daunorubicin hydrochloride Doxorubicin hydrochloride Etoposide Citrovorum factor Vindesine Dexamethasone acetate Mitoxantrone Mitoxantrone hydrochloride Doxiproct plus Medrol veriderm Proctofoam-HC Hydrocortisone hemisuccinate Hydrocortamate Methylprednisolone Myocet Etoposide phosphate Prednisolone sodium phosphate Hydrocortisone 21-sodium succinate Cytarabine Thioguanine Hydrocortisone cypionate Leucovorin Calcium Prednisolone Sodium Succinate Dexamethasone Sodium Phosphate Vincristine sulfate Cortisol succinate Methylprednisolone Sodium Succinate Methylprednisolone hemisuccinate Cortisol 21-phosphate Folinic acid calcium salt pentahydrate Mercaptopurine 6-Methylprednisolone L-Asparaginase

U.S. FDA Resources

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:

Event-free survival after first randomization [ Designated as safety issue: No ]
Disease-free survival after second and third randomization [ Designated as safety issue: No ]

Secondary Outcome Measures:

Overall survival [ Designated as safety issue: No ]
Response to prephase as assessed by number of blasts/mm³ in peripheral blood (< 1,000 vs ≥ 1,000) after randomization [ Designated as safety issue: No ]
Response as assessed by bone marrow (BM) blasts after first randomization, at evaluation of prephase, and on day 15 of induction [ Designated as safety issue: No ]
Toxicity and long-term toxicity as assessed by CTC v2 [ Designated as safety issue: Yes ]

Estimated Enrollment:	1500
Study Start Date:	December 1998
Estimated Primary Completion Date:	May 2008 (Final data collection date for primary outcome measure)

Hide Detailed Description

Detailed Description:

OBJECTIVES:

Compare the value of dexamethasone (DM) vs prednisolone (PRDL) administered during induction therapy, in terms of event-free and overall survival, in children with acute lymphoblastic leukemia (ALL) or lymphoblastic non-Hodgkin's lymphoma (LNHL).
Assess the value of increasing the number of administrations of asparaginase during consolidation and late intensification therapy, in terms of disease-free and overall survival, in children without very high-risk (VHR) features.
Compare the response rate in children treated with prephase therapy comprising DM vs PRDL and intrathecal methotrexate.
Compare the incidence and grade of toxic effects of these treatment regimens in these children.
Compare the long-term effects of these treatment regimens on growth and pubertal development, neurocognitive, cardiac, and endocrine function, and incidence of aseptic bone necrosis in these children.
Evaluate the proportion of children with VHR disease when defined according to extended VHR criteria, and assess the prognostic importance of the new VHR features (cytogenetics and minimal-residual disease).
Compare the feasibility of the VHR chemotherapy protocol in patients treated with DM vs PRDL.

OUTLINE: This is a randomized, multicenter study. Patients are stratified for prephase therapy according to center, disease (acute lymphoblastic leukemia [ALL] vs non-Hodgkin's lymphoma [NHL]), WBC for ALL patients (less than 10,000/mm^3 vs 10,000/mm^3 to less than 100,000/mm^3 vs greater than 100,000/mm^3), stage for NHL patients (I or II vs III or IV), and whether prephase already started (yes vs no). Patients are stratified for protocol II therapy according to center, risk group (very low risk [VLR] vs average risk 1 [AR1] vs average risk 2 [AR2]), and treatment arm at first randomization.

Prephase: Patients are randomized to 1 of 2 treatment arms
- Arm I: Patients receive oral prednisolone (PRDL) twice daily or methylprednisolone IV over 1 hour every 12 hours on days 1-7.
- Arm II: Patients receive dexamethasone (DM) orally twice daily or IV over 1 hour every 12 hours on days 1-7.

Patients in both arms also receive methotrexate (MTX) intrathecally (IT) on day 1.

Protocol IA (days 8-35):
- VLR patients: Patients receive either oral PRDL or oral DM (depending on earlier randomization) on days 8-28; vincristine (VCR) IV on days 8, 15, 22, and 29; daunorubicin (DNR) IV over 1-4 hours on days 8 and 15; MTX IT on days 12 and 25; and asparaginase (ASP) IV over 1 hour or intramuscularly (IM) on days 12, 15, 18, 22, 25, 29, 32, and 35.
- AR1 patients: Patients receive PRDL or DM, VCR, and ASP in the same manner as VLR patients. Patients also receive DNR IV over 1-4 hours on days 8, 15, 22, and 29 and triple intrathecal therapy (TIT) comprising MTX, cytarabine (ARA-C), and hydrocortisone on days 12 and 25.
- AR2 and very high-risk (VHR) patients:Patients receive PRDL or DM, VCR, and ASP in the same manner as VLR patients and high-dose MTX (HD-MTX) IV over 24 hours on day 8; cyclophosphamide (CTX) IV over 1 hour on day 9; DNR IV over 1-4 hours on days 15, 22, and 29; and TIT on days 12 and 25.

Patients with VLR, AR1, or AR2 disease after protocol IA proceed to protocol IB, interval therapy, and then protocol II. Patients with VHR disease after protocol IA proceed to the VHR patient protocol.

Protocol IB (for VLR, AR1, or AR2 patients): Patients with precursor B-cell ALL must be in complete remission (CR) and patients with NHL must be in CR or good partial remission.
- VLR patients: Patients receive oral mercaptopurine (MP) on days 36-63; ARA-C IV on days 38-41, 45-48, 52-55, and 59-62; and MTX IT on days 38 and 52.
- AR1 and AR2 patients: Patients receive oral MP and ARA-C in the same manner as VLR patients; CTX IV over 1 hour on days 36 and 63; and TIT on days 38 and 52.
- VLR, AR1, and AR2 patients are also randomized to 1 of 2 treatment arms.
  - Arm I: Patients receive ASP IV or IM on days 38, 41, 45, 48, 52, 55, 59, and 62.
  - Arm II: Patients receive no ASP.
Interval therapy for VLR, AR1, or AR2 patients (begins 14 days after completion of protocol I): Patients receive oral MP daily on days 1-56; HD-MTX IV over 24 hours on days 8, 22, 36, and 50; leucovorin calcium (CF) (or levofolinic acid) orally or IV beginning 36 hours after initiation of MTX infusion and repeating every 6 hours until hour 72 or until serum MTX level is adequate; and TIT on days 9, 23, 37, and 51.
Protocol II (reinduction therapy IIA and reconsolidation therapy IIB):
- VLR patients: Patients receive oral DM twice daily on days 1-21; VCR IV on days 8, 15, 22, and 29; doxorubicin (DOX) IV over 1-4 hours on days 8 and 15; ARA-C IV on days 38-41 and 45-48; oral thioguanine (TG) once daily on days 36-49; and MTX IT on day 38.
- AR patients: Patients receive DM, VCR, ARA-C, and TG in the same manner as VLR patients; DOX IV over 1-4 hours on days 8, 15, 22, and 29; CTX IV over 30-60 minutes on day 36; and TIT on day 38.
- VLR and AR patients are also randomized to 1 of 2 treatment arms.
  - Arm I: Patients receive short-term ASP IV over 1 hour or IM on days 8, 11, 15, and 18.
  - Arm II: Patients receive long-term ASP IV over 1 hour or IM on days 8, 11, 15, 18, 22, 25, 29, and 32.
Maintenance therapy for VLR and AR patients (begins 14 days after completion of protocol II):
- VLR patients: Patients receive oral MP once daily and oral MTX once weekly for a total of 74 weeks.
- AR1 patients: Patients receive oral MP once daily on days 1-70; oral MTX on days 1, 8, 15, 29, 36, 43, 50, 57, and 64; and TIT on day 22. Treatment repeats every 10 weeks for 6 courses.
- AR2 patients: Patients receive MP and oral MTX (as for AR1 patients); HD-MTX IV over 24 hours on day 22; CF as in interval therapy on days 23 and 24; and TIT and ASP on day 23.

After course 6, AR1 and AR2 patients receive further maintenance therapy comprising oral MP once daily and oral MTX once a week.

VHR patient protocol (recommended treatment): Patients with VHR disease after protocol IA receive reinforced consolidation (protocol IB') and VANDA regimens.
- Protocol IB': Patients receive oral DM twice daily on days 36-40 and 50-54; oral MP daily on days 36-40; VCR IV on days 36 and 41; HD-MTX IV over 24 hours on days 36 and 50; TIT on days 37 and 51; ARA-C IV over 3 hours every 12 hours on day 40; ASP IV over 1 hour or IM on days 41, 43, 45, 55, 57, and 59; oral TG once daily on days 50-54; vindesine (DAVA) IV on day 50; DNR IV over 1-4 hours on day 54; and CTX IV over 1 hour on days 52 and 53. Patients who achieve CR after protocol IB' proceed to VANDA regimen.
- VANDA regimen: Patients receive oral DM twice daily on days 1-5; ARA-C IV over 3 hours every 12 hours on days 1 and 2; mitoxantrone IV over 1 hour on days 3 and 4; etoposide (VP-16) IV over 1 hour on days 3-5; TIT on day 5; and ASP IV or IM on days 7, 9, 11, and 13.

After protocol IB' and VANDA, VHR patients who are eligible for stem cell transplantation (SCT) and have an HLA-compatible familial donor undergo transplantation. Patients who are ineligible for SCT receive interval therapy, followed by 2 sequences of blocks R1, R2, and R3 (2 courses of each block for a total of 6 courses), and then maintenance therapy for a total treatment duration of 2 years.

Interval therapy: Patients receive oral MP once daily on days 1-42; HD-MTX IV over 24 hours on days 8, 22, and 36; CF as in interval therapy (described above); and TIT on days 9, 23, and 37.
Blocks R1, R2, and R3 (this sequential regimen is repeated once):
- R1: Patients receive oral DM twice daily and oral MP once daily on days 1-5; VCR IV on days 1 and 6; HD-MTX IV over 24 hours on day 1; CF as in interval therapy on days 1 and 2; TIT on day 2; ARA-C IV over 3 hours every 12 hours on day 5; and ASP IV over 1 hour or IM on day 6.
- R2: Patients receive DM, HD-MTX, CF, TIT, and ASP as in block R1 and oral TG once daily on days 1-5; DAVA IV on day 1; CTX IV over 1 hour on days 3 and 4; and DNR IV over 1-4 hours on day 5.
- R3: Patients receive DM and ASP as in block R1 and ARA-C IV over 3 hours every 12 hours on days 1 and 2; VP-16 IV over 1 hour on days 3-5; and TIT on day 5.
Maintenance therapy: (begins 14 days after the second course of block R3 and ends 2 years after initiation of study therapy): Patients receive treatment as in maintenance therapy for AR1 patients. Treatment repeats every 10 weeks for 5 courses.

Patients are followed every 3 months for 5 years and then annually thereafter.

PROJECTED ACCRUAL: A total of 1,400-1,500 patients will be accrued for this study within 5.5 years.

Eligibility

Ages Eligible for Study:	up to 17 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

DISEASE CHARACTERISTICS:

Histologically confirmed acute lymphoblastic leukemia (ALL) of FAB L1 or L2 morphology
- Positive SIg allowed OR
Histologically confirmed precursor B or precursor T lymphoblastic non-Hodgkin's lymphoma (NHL)
- No diffuse large cell B-cell lymphoma, Burkitt's lymphoma, or high-grade B-cell lymphoma (Burkitt-like)
Very low-risk (VLR) patients meeting 1 of the following criteria:
- ALL of B-cell lineage
  - WBC less than 10,000/mm^3
  - Must meet 1 of the following conditions:
    - DNA index greater than 1.16 and less than 1.50 and chromosome number 51-66 or unknown
    - DNA index not assessed and chromosome number 51-66
    - DNA index greater than 1.16 and less than 1.50 and chromosome number is unknown
  - Good response to prephase therapy
  - Absence of t(9;22) or BCR/ABL, t(4;11)/MLL-AF4, or 11q23/MLL rearrangement
  - No acute undifferentiated leukemia (AUL)
  - No CNS or gonadal involvement
- Precursor B-lymphoblastic NHL stage I or II OR
Average risk (AR) patients:
- Must meet 1 of the following criteria:
  - ALL with good response to prephase therapy who are neither VLR or very high risk (VHR)
  - VLR ALL with CNS involvement (CSF positive or negative)
  - Precursor B-lymphoblastic NHL stage III or IV without any VHR feature
  - Precursor T-lymphoblastic NHL
- AR patients substratified in:
  - AR1: B-cell lineage ALL with WBC less than 100,000/mm^3
    - Surreptitious or hemorrhagic CSF becoming negative at D4 of prephase therapy
    - Precursor B-lymphoblastic NHL stage III or IV
    - Precursor T-lymphoblastic NHL stage I or II
  - AR2: B-cell lineage ALL with WBC at least 100,000/mm^3
    - T-cell lineage ALL regardless of the WBC
    - Overt or non-equivocal CNS involvement at D0 or any CSF involvement at D4
    - Gonadal involvement
    - Precursor T-lymphoblastic NHL stage III or IV
- Newborn Down syndrome patients with AR2 features are assigned to the AR1 group OR
VHR patients:
- Must meet 1 of the following criteria:
  - ALL patients meeting 1 of the following conditions:
    - Poor response to prephase therapy (at least 1,000/mm^3 blasts in peripheral blood after completion of prephase therapy)
    - t(9;22) or BCR/ABL
    - t(4;11)/MLL-AF4 = 11q23/MLL rearrangement
    - Near haploidy (no more than 34 chromosomes or DNA index less than 0.7)
    - Hypodiploid (35-40 chromosomes or DNA index 0.7 to 0.8)
    - AUL
    - For B lineage ALL: failure to achieve complete response (CR) after completion of protocol IA
    - For T lineage ALL: failure to achieve CR or good partial response (GPR) after completion of protocol IA
    - Minimal-residual disease (greater than 1,000 blasts/100,000 mononuclear bone marrow cells) at evaluation of IA (day 35)
  - NHL patients who failed to achieve CR or GPR after completion of protocol IA
- All VHR patients are eligible for stem cell transplantation except those whose sole VHR criterion is a poor response to prephase therapy and who have none of the following features:
  - T-cell immunophenotype
  - Early B ALL (CD10 negative)
  - WBC at least 100,000/mm^3
- Newborn Down syndrome patients with VHR features are assigned to AR1 group NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.

PATIENT CHARACTERISTICS:

Age:

Under 18

Performance status:

Not specified

Life expectancy:

Not specified

Hematopoietic:

See Disease Characteristics

Hepatic:

Not specified

Renal:

Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy:

See Disease Characteristics

Chemotherapy:

Not specified

Endocrine therapy:

Not specified

Radiotherapy:

Not specified

Surgery:

Not specified

Other:

No prior therapy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00003728

Locations

Belgium
Academisch Ziekenhuis der Vrije Universiteit Brussel	Recruiting
Brussels, Belgium, 1090
Contact: Contact Person 32-2-477-6040
Centre Hospitalier Regional de la Citadelle	Recruiting
Liege, Belgium, 4000
Contact: Contact Person 32-4-225-6111
Clinique de l'Esperance	Recruiting
Montegnee, Belgium, 4420
Contact: Contact Person 32-4-224-9111
Ghent University	Recruiting
Ghent, Belgium, B-9000
Contact: Contact Person Not Available
Hopital Universitaire Des Enfants Reine Fabiola	Recruiting
Brussels, Belgium, 1020
Contact: Contact Person 32-2-477-3282
U.Z. Gasthuisberg	Recruiting
Leuven, Belgium, B-3000
Contact: Contact Person 32-16-332-211
Universitair Ziekenhuis Gent	Recruiting
Ghent, Belgium, B-9000
Contact: Contact Person 32-9-240-2011
Ziekenhuis Netwerk Antwerpen Middelheim	Recruiting
Antwerp, Belgium, 2020
Contact: Contact Person 32-3-280-3111
France
Centre Hospitalier Regional et Universitaire d'Angers	Recruiting
Angers, France, 49033
Contact: Contact Person 33-2-4148-1066
CHR de Besancon - Hopital Saint-Jacques	Recruiting
Besancon, France, 25030
Contact: Contact Person 33-3-8166-8166
CHR Hotel Dieu	Recruiting
Nantes, France, 44035
Contact: Contact Person 33-240-083-272
CHU - Hopital Robert Debre	Recruiting
Paris, France, 75019
Contact: Contact Person 33-1-4003-2350
CHU de Caen	Recruiting
Caen, France, 14033
Contact: Contact Person 33-2-3106-3106
CHU de Grenoble - Hopital de la Tronche	Recruiting
Grenoble, France, 38043
Contact: Contact Person 33-476-767-575
Hopital Americain	Recruiting
Reims, France, 51092
Contact: Contact Person 33-326-787-789
Hopital Arnaud de Villeneuve	Recruiting
Montpellier, France, 34059
Contact: Contact Person 33-467-336-733
Hopital de l'Archet CHU de Nice	Recruiting
Nice, France, F-06202
Contact: Contact Person 33-492-035-555
Hopital Debrousse	Recruiting
Lyon, France, 69322
Contact: Contact Person 33-472-385-757
Hopital des Enfants	Recruiting
Toulouse, France, 31026
Contact: Contact Person 33-561-05345-58584
Hopital Jean Bernard	Recruiting
Poitiers, France, 86021
Contact: Contact Person 33-5-4944-4444
Hopital Universitaire Hautepierre	Recruiting
Strasbourg, France, 67098
Contact: Contact Person 33-388-128-000
Portugal
Hospital Escolar San Joao	Recruiting
Porto, Portugal, 4200
Contact: Contact Person 351-2-502-7151
Instituto Portugues de Oncologia Centro do Porto, SA	Recruiting
Porto, Portugal, 4200
Contact: Contact Person 351-2-550-2011

Sponsors and Collaborators

European Organization for Research and Treatment of Cancer

Investigators

Investigator:

Jacques Otten, MD

Academisch Ziekenhuis der Vrije Universiteit Brussel

More Information

Additional Information:

Clinical trial summary from the National Cancer Institute's PDQ® database This link exits the ClinicalTrials.gov site

Publications:

Bertrand Y, Suciu S, Benoit Y, et al.: Dexamethasone(DEX)(6mg/sm/d) and prednisolone(PRED)(60mg/sm/d) in induction therapy of childhood ALL are equally effective: results of the 2nd interim analysis of EORTC trial 58951. [Abstract] Blood 112 (11): A-8, 2008.

De Moerloose B, Suciu S, Bertrand Y, et al.: Improved outcome with pulses of vincristine and steroids in continuation therapy of children with average risk acute lymphoblastic leukemia (ALL) and non Hodgkin lymphoma (NHL): final report of the EORTC randomized phase III trial 58951. [Abstract] Blood 112 (11): A-11, 2008.

Sirvent N, Suciu S, Benoit Y, et al.: Prognostic significance of central nervous system (CNS) status of children with acute lymphoblastic leukemia (ALL) treated without cranial irradiation: results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group study 58951. [Abstract] Blood 112 (11): A-303, 2008.

Bertrand Y, Goutagny MP, Poulat AL, et al.: Asparagine depletion, safety and antibody production after E coli asparaginase treatment in children with newly diagnosed acute lymphoblastic leukaemia treated with EORTC 58951 protocol: a single center report. [Abstract] Blood 110 (11): A-4337, 2007.

Cave H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Mechinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N; EORTC-CLG. Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. Blood. 2004 Jan 15;103(2):442-50. Epub 2003 Sep 22.

Mirebeau D, Acquaviva C, Suciu S, et al.: Is CDKN2A +/- CDKN2B and MTAP inactivation of prognostic significance in B-precursor childhood acute lymphoblastic leukemia? Results of EORTC studies 58881 and 58951. [Abstract] Blood 104 (11): A-1076, 2004.

Cavé H, Suciu S, Preudhomme C, et al.: HOX11L2 expression linked to t(5;14)(q35;q32) is not associated with poor prognosis in childhood T-ALL treated in EORTC trials 58 881 and 58 951. [Abstract] Blood 100(11 pt 1): A-576, 153a, 2002.

Study ID Numbers:	CDR0000066840, EORTC-58951
Study First Received:	November 1, 1999
Last Updated:	June 16, 2009
ClinicalTrials.gov Identifier:	NCT00003728 History of Changes
Health Authority:	Unspecified

Keywords provided by National Cancer Institute (NCI):

stage I childhood lymphoblastic lymphoma
stage II childhood lymphoblastic lymphoma
stage III childhood lymphoblastic lymphoma
stage IV childhood lymphoblastic lymphoma
untreated childhood acute lymphoblastic leukemia

L1 childhood acute lymphoblastic leukemia
L2 childhood acute lymphoblastic leukemia
T-cell childhood acute lymphoblastic leukemia
B-cell childhood acute lymphoblastic leukemia
acute undifferentiated leukemia

Additional relevant MeSH terms:

Anti-Inflammatory Agents
Dexamethasone
Anti-Infective Agents
Hydrocortisone
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Methylprednisolone
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Antiemetics
6-Mercaptopurine
Hormones
Therapeutic Uses
Abortifacient Agents
Methotrexate

Dermatologic Agents
Etoposide
Nucleic Acid Synthesis Inhibitors
Methylprednisolone Hemisuccinate
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunoproliferative Disorders
Antineoplastic Agents, Hormonal
Immune System Diseases
Thioguanine
Vincristine
Abortifacient Agents, Nonsteroidal
Glucocorticoids
Doxorubicin
Neoplasms

ClinicalTrials.gov processed this record on November 27, 2009