|
|
Home
Search
Study Topics
Glossary
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||||||||||
| Sponsor: | Children's Oncology Group |
|---|---|
| Collaborator: |
National Cancer Institute (NCI) |
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00002798 |
Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. It is not yet known which treatment regimen is more effective for acute myelogenous leukemia or myelodysplastic syndrome.
PURPOSE: Randomized phase III trial to compare the effectiveness of different chemotherapy regimens with or without bone marrow transplantation in treating children who have acute myelogenous leukemia or myelodysplastic syndrome.
| Condition | Intervention | Phase |
|---|---|---|
|
Leukemia Myelodysplastic Syndromes |
Biological: aldesleukin Biological: filgrastim Drug: asparaginase Drug: busulfan Drug: cyclophosphamide Drug: cytarabine Drug: daunorubicin hydrochloride Drug: dexamethasone Drug: etoposide Drug: fludarabine phosphate Drug: idarubicin Drug: methotrexate Drug: therapeutic hydrocortisone Drug: thioguanine Procedure: allogeneic bone marrow transplantation Radiation: radiation therapy |
Phase III |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Active Control |
| Official Title: | A PHASE III STUDY IN CHILDREN WITH UNTREATED ACUTE MYELOGENOUS LEUKEMIA (AML) OR MYELODYSPLASTIC SYNDROME (MDS) |
Eligibility| Ages Eligible for Study: | up to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Histologically confirmed previously untreated acute myeloid leukemia (AML) in patients 1 month to 21 years of age
Infants under 1 month with progressive disease eligible
Histochemical verification of AML required by the following stains:
Combined NSE/NaF and butyrate inhibition or diagnosis of megakaryoblastic leukemia (FAB M7) should be supported by one of the following:
The following are also eligible:
Myelodysplastic syndromes, including:
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoeitic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy :
Surgery:
Other:
Contacts and Locations
Hide Study Locations| United States, Alabama | |
| University of Alabama at Birmingham Comprehensive Cancer Center | |
| Birmingham, Alabama, United States, 35233 | |
| University of South Alabama Medical Center | |
| Mobile, Alabama, United States, 36604 | |
| United States, Arizona | |
| Arizona Cancer Center | |
| Tucson, Arizona, United States, 85724 | |
| Phoenix Children's Hospital | |
| Phoenix, Arizona, United States, 85016-7710 | |
| United States, Arkansas | |
| University of Arkansas for Medical Sciences | |
| Little Rock, Arkansas, United States, 72205 | |
| United States, California | |
| Cancer Center and Beckman Research Institute, City of Hope | |
| Duarte, California, United States, 91010-3000 | |
| Cedars-Sinai Medical Center | |
| Los Angeles, California, United States, 90048 | |
| Jonsson Comprehensive Cancer Center, UCLA | |
| Los Angeles, California, United States, 90095-1781 | |
| Children's Hospital and Health Center | |
| San Diego, California, United States, 92123-4282 | |
| Children's Hospital of Oakland | |
| Oakland, California, United States, 94609-1809 | |
| Children's Hospital of Orange County | |
| Orange, California, United States, 92868 | |
| David Grant Medical Center | |
| Travis Air Force Base, California, United States, 94535 | |
| Jonathan Jaques Children's Cancer Center | |
| Long Beach, California, United States, 90801-1428 | |
| Children's Hospital Los Angeles | |
| Los Angeles, California, United States, 90027-0700 | |
| Kaiser Permanente Medical Center - Santa Clara | |
| Santa Clara, California, United States, 95051-5386 | |
| Kaiser Permanente Medical Group - San Francisco | |
| San Francisco, California, United States, 94115 | |
| Kaiser Permanente-Southern California Permanente Medical Group | |
| San Diego, California, United States, 92120 | |
| Loma Linda University Medical Center | |
| Loma Linda, California, United States, 92354 | |
| Southern California Permanente Medical Group | |
| Downey, California, United States, 90242 | |
| Santa Barbara Cottage Hospital | |
| Santa Barbara, California, United States, 93102 | |
| Lucile Packard Children's Hospital at Stanford | |
| Palo Alto, California, United States, 94304 | |
| Sutter Cancer Center | |
| Sacramento, California, United States, 95816 | |
| UCSF Cancer Center and Cancer Research Institute | |
| San Francisco, California, United States, 94143-0128 | |
| University of California Davis Medical Center | |
| Sacramento, California, United States, 95817 | |
| Chao Family Comprehensive Cancer Center | |
| Orange, California, United States, 92868 | |
| University of California San Diego Cancer Center | |
| La Jolla, California, United States, 92103-8447 | |
| Children's Hospital Central California | |
| Madera, California, United States, 93638-8762 | |
| United States, Colorado | |
| Childhood Hematology/Oncology Associates | |
| Denver, Colorado, United States, 80218 | |
| Children's Hospital of Denver | |
| Denver, Colorado, United States, 80218-1088 | |
| Presbyterian-St Luke's Medical Center | |
| Denver, Colorado, United States, 80218 | |
| United States, Connecticut | |
| University of Connecticut Health Center | |
| Farmington, Connecticut, United States, 06360-7106 | |
| Yale Comprehensive Cancer Center | |
| New Haven, Connecticut, United States, 06520-8028 | |
| United States, Delaware | |
| Alfred I. Dupont Institute | |
| Wilmington, Delaware, United States, 19899 | |
| United States, District of Columbia | |
| Children's National Medical Center | |
| Washington, District of Columbia, United States, 20010-2970 | |
| Lombardi Cancer Center | |
| Washington, District of Columbia, United States, 20007 | |
| Walter Reed Army Medical Center | |
| Washington, District of Columbia, United States, 20307-5000 | |
| United States, Florida | |
| Nemours Children's Clinic | |
| Jacksonville, Florida, United States, 32207 | |
| Baptist Hospital of Miami | |
| Miami, Florida, United States, 33176-2197 | |
| Broward General Medical Center | |
| Fort Lauderdale, Florida, United States, 33316 | |
| Children's Hospital of Southwest Florida | |
| Fort Myers, Florida, United States, 33908 | |
| Joe DiMaggio Children's Hospital at Memorial | |
| Hollywood, Florida, United States, 33021 | |
| Miami Children's Hospital | |
| Miami, Florida, United States, 33155-4069 | |
| All Children's Hospital | |
| St. Petersburg, Florida, United States, 33701 | |
| Nemours Children's Clinic-Orlando | |
| Orlando, Florida, United States, 32806 | |
| Sacred Heart Children's Hospital | |
| Pensacola, Florida, United States, 32504 | |
| Shands Hospital and Clinics, University of Florida | |
| Gainesville, Florida, United States, 32610-100277 | |
| St. Mary's Hospital | |
| West Palm Beach, Florida, United States, 33407 | |
| Florida Hospital Cancer Institute | |
| Orlando, Florida, United States, 32803 | |
| University of Miami-Jackson Memorial Hospital | |
| Miami, Florida, United States, 33136 | |
| Tampa Children's Hospital | |
| Tampa, Florida, United States, 33677-4227 | |
| United States, Georgia | |
| Emory University Hospital - Atlanta | |
| Atlanta, Georgia, United States, 30322 | |
| Children's Healthcare of Atlanta - Scottish Rite | |
| Atlanta, Georgia, United States, 30342 | |
| Medical Center of Central Georgia | |
| Macon, Georgia, United States, 31201 | |
| Medical College of Georgia Comprehensive Cancer Center | |
| Augusta, Georgia, United States, 30912-4000 | |
| Memorial Health University Medical Center, Inc. | |
| Savannah, Georgia, United States, 31403-3089 | |
| United States, Hawaii | |
| Cancer Research Center of Hawaii | |
| Honolulu, Hawaii, United States, 96813 | |
| Tripler Army Medical Center | |
| Honolulu, Hawaii, United States, 96859-5000 | |
| United States, Idaho | |
| Mountain States Tumor Institute | |
| Boise, Idaho, United States, 83712 | |
| United States, Illinois | |
| Children's Memorial Hospital, Chicago | |
| Chicago, Illinois, United States, 60614 | |
| Hope Children's Hospital | |
| Oak Lawn, Illinois, United States, 60453 | |
| Lutheran General Hospital | |
| Park Ridge, Illinois, United States, 60068-1174 | |
| University of Chicago Cancer Research Center | |
| Chicago, Illinois, United States, 60601 | |
| Saint Jude Midwest Affiliate | |
| Peoria, Illinois, United States, 61637 | |
| Southern Illinois University School of Medicine | |
| Springfield, Illinois, United States, 62794-9658 | |
| Rush-Presbyterian-St. Luke's Medical Center | |
| Chicago, Illinois, United States, 60612 | |
| University of Illinois at Chicago | |
| Chicago, Illinois, United States, 60612 | |
| United States, Indiana | |
| Indiana University Cancer Center | |
| Indianapolis, Indiana, United States, 46202-5289 | |
| St. Vincent Hospital and Health Care Center | |
| Indianapolis, Indiana, United States, 46260 | |
| United States, Iowa | |
| Holden Comprehensive Cancer Center | |
| Iowa City, Iowa, United States, 52242-1009 | |
| Raymond Blank Memorial Hospital for Children | |
| Des Moines, Iowa, United States, 50309 | |
| United States, Kansas | |
| Wesley Medical Center | |
| Wichita, Kansas, United States, 67214 | |
| United States, Kentucky | |
| Albert B. Chandler Medical Center, University of Kentucky | |
| Lexington, Kentucky, United States, 40536-0284 | |
| Kosair Children's Hospital | |
| Louisville, Kentucky, United States, 40202-3830 | |
| United States, Louisiana | |
| Children's Hospital of New Orleans | |
| New Orleans, Louisiana, United States, 70118 | |
| Ochsner Clinic | |
| New Orleans, Louisiana, United States, 70121 | |
| Tulane University School of Medicine | |
| New Orleans, Louisiana, United States, 70112 | |
| United States, Maine | |
| Eastern Maine Medical Center | |
| Bangor, Maine, United States, 04401 | |
| Maine Children's Cancer Program | |
| Scarborough, Maine, United States, 04074 | |
| United States, Maryland | |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Baltimore, Maryland, United States, 21231-2410 | |
| Marlene and Stewart Greenebaum Cancer Center, University of Maryland | |
| Baltimore, Maryland, United States, 21201-1595 | |
| Sinai Hospital of Baltimore | |
| Baltimore, Maryland, United States, 21225 | |
| United States, Massachusetts | |
| Baystate Medical Center | |
| Springfield, Massachusetts, United States, 01107 | |
| Floating Hospital for Children | |
| Boston, Massachusetts, United States, 02111 | |
| Dana-Farber Cancer Institute | |
| Boston, Massachusetts, United States, 02115 | |
| University of Massachusetts Memorial Medical Center - University Campus | |
| Worcester, Massachusetts, United States, 01655 | |
| United States, Michigan | |
| Bronson Methodist Hospital | |
| Kalamazoo, Michigan, United States, 49007 | |
| Children's Hospital of Michigan | |
| Detroit, Michigan, United States, 48201 | |
| Henry Ford Hospital | |
| Detroit, Michigan, United States, 48202 | |
| Hurley Medical Center | |
| Flint, Michigan, United States, 48503 | |
| Michigan State University | |
| East Lansing, Michigan, United States, 48824 | |
| William Beaumont Hospital | |
| Royal Oak, Michigan, United States, 48073-6769 | |
| Spectrum Health and DeVos Children's Hospital | |
| Grand Rapids, Michigan, United States, 49503 | |
| St. John Hospital and Medical Center | |
| Detroit, Michigan, United States, 48236 | |
| Mott Children's Hospital | |
| Ann Arbor, Michigan, United States, 48109-0914 | |
| United States, Minnesota | |
| Children's Hospitals and Clinics - Minneapolis | |
| Minneapolis, Minnesota, United States, 55404 | |
| Children's Hospitals and Clinics of Minnesota | |
| Saint Paul, Minnesota, United States, 55102 | |
| St. Mary's/Duluth Clinic Cancer Center | |
| Duluth, Minnesota, United States, 55805-1983 | |
| Mayo Clinic Cancer Center | |
| Rochester, Minnesota, United States, 55905 | |
| United States, Mississippi | |
| University of Mississippi Medical Center | |
| Jackson, Mississippi, United States, 39216-4505 | |
| United States, Missouri | |
| Cardinal Glennon Children's Hospital | |
| Saint Louis, Missouri, United States, 63104 | |
| Children's Mercy Hospital | |
| Kansas City, Missouri, United States, 64108 | |
| St. Louis Children's Hospital | |
| Saint Louis, Missouri, United States, 63110 | |
| United States, Nebraska | |
| Children's Hospital of Omaha | |
| Omaha, Nebraska, United States, 68114 | |
| University of Nebraska Medical Center | |
| Omaha, Nebraska, United States, 68198-2168 | |
| United States, Nevada | |
| Sunrise Hospital and Medical Center | |
| Las Vegas, Nevada, United States, 89109-2306 | |
| United States, New Hampshire | |
| Norris Cotton Cancer Center | |
| Lebanon, New Hampshire, United States, 03756-0002 | |
| United States, New Jersey | |
| Atlantic Health System | |
| Summit, New Jersey, United States, 07901 | |
| Cancer Institute of New Jersey | |
| New Brunswick, New Jersey, United States, 08903 | |
| Hackensack University Medical Center | |
| Hackensack, New Jersey, United States, 07601 | |
| Newark Beth Israel Medical Center | |
| Newark, New Jersey, United States, 07112-2094 | |
| St. Joseph's Hospital and Medical Center | |
| Paterson, New Jersey, United States, 07503 | |
| United States, New Mexico | |
| University of New Mexico Cancer Research and Treatment Center | |
| Albuquerque, New Mexico, United States, 87131 | |
| United States, New York | |
| Cancer Center of Albany Medical Center | |
| Albany, New York, United States, 12208 | |
| Brooklyn Hospital Center | |
| Brooklyn, New York, United States, 11201 | |
| Brookdale University Hospital and Medical Center | |
| Brooklyn, New York, United States, 11212 | |
| Columbia Presbyterian Hospital | |
| New York, New York, United States, 10032 | |
| Maimonides Medical Center | |
| Brooklyn, New York, United States, 11219 | |
| Memorial Sloan-Kettering Cancer Center | |
| New York, New York, United States, 10021 | |
| Montefiore Medical Center | |
| Bronx, New York, United States, 10467-2490 | |
| North Shore University Hospital | |
| Manhasset, New York, United States, 11030 | |
| New York Medical College | |
| Valhalla, New York, United States, 10595 | |
| New York Presbyterian Hospital - Cornell Campus | |
| New York, New York, United States, 10021-4885 | |
| Mount Sinai School of Medicine | |
| New York, New York, United States, 10029 | |
| Roswell Park Cancer Institute | |
| Buffalo, New York, United States, 14263-0001 | |
| Schneider Children's Hospital | |
| New Hyde Park, New York, United States, 11042 | |
| State University of New York - Upstate Medical University | |
| Syracuse, New York, United States, 13210 | |
| State University of New York Health Science Center at Brooklyn College of Medicine | |
| Brooklyn, New York, United States, 11203 | |
| State University of New York Health Sciences Center - Stony Brook | |
| Stony Brook, New York, United States, 11790-7775 | |
| James P. Wilmot Cancer Center | |
| Rochester, New York, United States, 14642 | |
| United States, North Carolina | |
| Carolinas Medical Center | |
| Charlotte, North Carolina, United States, 28232-2861 | |
| Comprehensive Cancer Center at Wake Forest University | |
| Winston-Salem, North Carolina, United States, 27157-1081 | |
| Duke Comprehensive Cancer Center | |
| Durham, North Carolina, United States, 27710 | |
| East Carolina University School of Medicine | |
| Greenville, North Carolina, United States, 27858-4354 | |
| Lineberger Comprehensive Cancer Center, UNC | |
| Chapel Hill, North Carolina, United States, 27599-7295 | |
| Mission Saint Joseph's Health System | |
| Asheville, North Carolina, United States, 28801 | |
| Presbyterian Healthcare | |
| Charlotte, North Carolina, United States, 28233-3549 | |
| United States, North Dakota | |
| Dakota Cancer Institute | |
| Fargo, North Dakota, United States, 58103-4940 | |
| United States, Ohio | |
| Ireland Cancer Center | |
| Cleveland, Ohio, United States, 44106-5065 | |
| Children's Hospital Medical Center of Akron | |
| Akron, Ohio, United States, 44308 | |
| Children's Hospital of Columbus | |
| Columbus, Ohio, United States, 43205-2696 | |
| Children's Medical Center - Dayton | |
| Dayton, Ohio, United States, 45404 | |
| Cleveland Clinic Taussig Cancer Center | |
| Cleveland, Ohio, United States, 44195 | |
| Forum Health-Tod Childrens Hospital | |
| Youngstown, Ohio, United States, 44501 | |
| Children's Hospital Medical Center - Cincinnati | |
| Cincinnati, Ohio, United States, 45229-2899 | |
| St. Vincent Mercy Medical Center | |
| Toledo, Ohio, United States, 43608 | |
| Toledo Children's Hospital | |
| Toledo, Ohio, United States, 43601 | |
| United States, Oklahoma | |
| Children's Hospital of Oklahoma | |
| Oklahoma City, Oklahoma, United States, 73104 | |
| Natalie Warren Bryant Cancer Center | |
| Tulsa, Oklahoma, United States, 74136 | |
| United States, Oregon | |
| Doernbecher Children's Hospital | |
| Portland, Oregon, United States, 97201-3098 | |
| Legacy Emanuel Hospital and Health Center | |
| Portland, Oregon, United States, 97227 | |
| United States, Pennsylvania | |
| Children's Hospital of Philadelphia | |
| Philadelphia, Pennsylvania, United States, 19104 | |
| Children's Hospital of Pittsburgh | |
| Pittsburgh, Pennsylvania, United States, 15213 | |
| Geisinger Medical Center | |
| Danville, Pennsylvania, United States, 17822-1320 | |
| Milton S. Hershey Medical Center | |
| Hershey, Pennsylvania, United States, 17033-0850 | |
| St. Christopher's Hospital for Children | |
| Philadelphia, Pennsylvania, United States, 19134-1095 | |
| United States, Rhode Island | |
| Rhode Island Hospital | |
| Providence, Rhode Island, United States, 02818 | |
| United States, South Carolina | |
| Medical University of South Carolina | |
| Charleston, South Carolina, United States, 29425-0721 | |
| Children's Hospital of Greenville Hospital System | |
| Greenville, South Carolina, United States, 29605 | |
| Palmetto Health South Carolina Cancer Center | |
| Columbia, South Carolina, United States, 29203 | |
| United States, South Dakota | |
| Avera Cancer Institute | |
| Sioux Falls, South Dakota, United States, 57105-1080 | |
| Sioux Valley Hospital | |
| Sioux Falls, South Dakota, United States, 57117 | |
| United States, Tennessee | |
| East Tennessee Children's Hospital | |
| Knoxville, Tennessee, United States, 37901 | |
| James H. Quillen College of Medicine | |
| Johnson City, Tennessee, United States, 37614-0622 | |
| Saint Jude Children's Research Hospital | |
| Memphis, Tennessee, United States, 38105-2794 | |
| Vanderbilt-Ingram Cancer Center | |
| Nashville, Tennessee, United States, 37232-6838 | |
| United States, Texas | |
| Baylor College of Medicine | |
| Houston, Texas, United States, 77030 | |
| Scott and White Memorial Hospital | |
| Temple, Texas, United States, 76508 | |
| Cook Children's Medical Center - Fort Worth | |
| Fort Worth, Texas, United States, 76104 | |
| Covenant Children's Hospital | |
| Lubbock, Texas, United States, 79410 | |
| Medical City Dallas Hospital | |
| Dallas, Texas, United States, 75230 | |
| Methodist Health Care System | |
| San Antonio, Texas, United States, 78229-3902 | |
| San Antonio Military Pediatric Cancer and Blood Disorders Center | |
| Lackland Air Force Base, Texas, United States, 78236-5300 | |
| Children's Hospital of Austin | |
| Austin, Texas, United States, 78701 | |
| Simmons Cancer Center - Dallas | |
| Dallas, Texas, United States, 75235-9154 | |
| Texas Tech University Health Sciences Center School of Medicine | |
| Amarillo, Texas, United States, 79106 | |
| University of Texas - MD Anderson Cancer Center | |
| Houston, Texas, United States, 77030-4009 | |
| University of Texas Health Science Center at San Antonio | |
| San Antonio, Texas, United States, 78207 | |
| University of Texas Medical Branch | |
| Galveston, Texas, United States, 77555-0361 | |
| United States, Utah | |
| Huntsman Cancer Institute | |
| Salt Lake City, Utah, United States, 84112 | |
| United States, Vermont | |
| Vermont Cancer Center | |
| Burlington, Vermont, United States, 05401-3498 | |
| United States, Virginia | |
| Cancer Center at the University of Virginia | |
| Charlottesville, Virginia, United States, 22908 | |
| Carilion Roanoke Community Hospital | |
| Roanoke, Virginia, United States, 24013 | |
| Children's Hospital of the King's Daughters | |
| Norfolk, Virginia, United States, 23507 | |
| Inova Fairfax Hospital | |
| Falls Church, Virginia, United States, 22042-3300 | |
| Massey Cancer Center | |
| Richmond, Virginia, United States, 23298-0037 | |
| Naval Medical Center, Portsmouth | |
| Portsmouth, Virginia, United States, 23708-5100 | |
| United States, Washington | |
| Children's Hospital and Regional Medical Center - Seattle | |
| Seattle, Washington, United States, 98105 | |
| Deaconess Medical Center | |
| Spokane, Washington, United States, 99210-0248 | |
| Fred Hutchinson Cancer Research Center | |
| Seattle, Washington, United States, 98109-1024 | |
| Group Health Cooperative of Puget Sound | |
| Seattle, Washington, United States, 98112 | |
| Madigan Army Medical Center | |
| Tacoma, Washington, United States, 98431-5000 | |
| Mary Bridge Children's Health Center | |
| Tacoma, Washington, United States, 98415-0299 | |
| United States, West Virginia | |
| West Virginia University Hospitals | |
| Morgantown, West Virginia, United States, 26506-9300 | |
| West Virginia University - Charleston | |
| Charleston, West Virginia, United States, 25302 | |
| Cabell-Huntington Hospital, Inc | |
| Huntington, West Virginia, United States, 25701 | |
| United States, Wisconsin | |
| CCOP - Green Bay | |
| Green Bay, Wisconsin, United States, 54301 | |
| Gundersen Lutheran Medical Center | |
| La Crosse, Wisconsin, United States, 54601 | |
| Marshfield Clinic | |
| Marshfield, Wisconsin, United States, 54449-5772 | |
| Midwest Children's Cancer Center | |
| Milwaukee, Wisconsin, United States, 53226 | |
| St. Vincent Hospital | |
| Green Bay, Wisconsin, United States, 54307-9070 | |
| University of Wisconsin Hospital and Clinics | |
| Madison, Wisconsin, United States, 53792-0001 | |
| Bellin Memorial Hospital | |
| Green Bay, Wisconsin, United States, 54301 | |
| Australia, New South Wales | |
| Children's Hospital at Westmead | |
| Westmead, New South Wales, Australia, 2145 | |
| Sydney Children's Hospital | |
| Randwick, New South Wales, Australia, 2031 | |
| Australia, Queensland | |
| Royal Children's Hospital | |
| Brisbane, Queensland, Australia, 4029 | |
| Australia, South Australia | |
| Women's and Children's Hospital | |
| North Adelaide, South Australia, Australia, 5006 | |
| Australia, Victoria | |
| Royal Children's Hospital | |
| Parkville, Victoria, Australia, 3052 | |
| Australia, Western Australia | |
| Princess Margaret Hospital for Children | |
| Perth, Western Australia, Australia, 6001 | |
| Canada, Alberta | |
| Alberta Children's Hospital | |
| Calgary, Alberta, Canada, T2T 5C7 | |
| Cross Cancer Institute | |
| Edmonton, Alberta, Canada, T6G 1Z2 | |
| Canada, British Columbia | |
| British Columbia Children's Hospital | |
| Vancouver, British Columbia, Canada, V6H 3V4 | |
| Canada, Manitoba | |
| CancerCare Manitoba | |
| Winnipeg, Manitoba, Canada, R3E 0V9 | |
| Canada, Newfoundland and Labrador | |
| Janeway Children's Health and Rehabilitation Centre | |
| St. John's, Newfoundland and Labrador, Canada, A1B 3V6 | |
| Canada, Nova Scotia | |
| IWK Health Centre | |
| Halifax, Nova Scotia, Canada, B3J 3G9 | |
| Canada, Ontario | |
| Children's Hospital of Western Ontario | |
| London, Ontario, Canada, N6C 2V5 | |
| Children's Hospital of Eastern Ontario | |
| Ottawa, Ontario, Canada, K1H 8L1 | |
| Children's Hospital | |
| Hamilton, Ontario, Canada, L8N 3Z5 | |
| Hospital for Sick Children | |
| Toronto, Ontario, Canada, M5G 1X8 | |
| Canada, Quebec | |
| Centre Hospitalier de L'Universite Laval | |
| Sainte Foy, Quebec, Canada, GIV 4G2 | |
| Hopital Sainte Justine | |
| Montreal, Quebec, Canada, H3T 1C5 | |
| Laval University Medical Center | |
| Sainte-Foy, Quebec, Canada, G1V 4G2 | |
| McGill University Health Center - Montreal Children's Hospital | |
| Montreal, Quebec, Canada, H3H 1P3 | |
| Canada, Saskatchewan | |
| Allan Blair Cancer Centre | |
| Regina, Saskatchewan, Canada, S4T 7T1 | |
| Saskatoon Cancer Centre | |
| Saskatoon, Saskatchewan, Canada, S7N 4H4 | |
| Netherlands | |
| Academisch Ziekenhuis Groningen | |
| Groningen, Netherlands, 9700 RB | |
| New Zealand | |
| Starship Children's Hospital | |
| Auckland, New Zealand | |
| Puerto Rico | |
| San Jorge Childrens Hospital | |
| Santurce, Puerto Rico, 00912 | |
| University of Puerto Rico School of Medicine Medical Sciences Campus | |
| San Juan, Puerto Rico, 00936-5067 | |
| Switzerland | |
| Swiss Pediatric Oncology Group Lausanne | |
| Lausanne, Switzerland, CH 1011 | |
| Swiss Pediatric Oncology Group Geneva | |
| Geneva, Switzerland, CH 1211 | |
| Swiss Pediatric Oncology Group Bern | |
| Bern, Switzerland, CH 3010 | |
| Study Chair: | Beverly J. Lange, MD | Children's Hospital of Philadelphia |
More Information
| Study ID Numbers: | CDR0000064883, COG-2961, CCG-2961 |
| Study First Received: | November 24, 2000 |
| Last Updated: | April 18, 2009 |
| ClinicalTrials.gov Identifier: | NCT00002798 History of Changes |
| Health Authority: | United States: Federal Government |
|
untreated childhood acute myeloid leukemia and other myeloid malignancies childhood acute myeloblastic leukemia without maturation (M1) childhood acute myeloblastic leukemia with maturation (M2) childhood acute myelomonocytic leukemia (M4) childhood acute monoblastic leukemia (M5a) childhood acute monocytic leukemia (M5b) childhood acute erythroleukemia (M6) childhood acute megakaryocytic leukemia (M7) |
refractory anemia refractory anemia with ringed sideroblasts refractory anemia with excess blasts refractory anemia with excess blasts in transformation chronic myelomonocytic leukemia de novo myelodysplastic syndromes secondary myelodysplastic syndromes childhood myelodysplastic syndromes |
|
Anti-Inflammatory Agents Dexamethasone Anti-Infective Agents Hydrocortisone Antimetabolites, Antineoplastic Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Hormones, Hormone Substitutes, and Hormone Antagonists Antiemetics Hormones Preleukemia Pathologic Processes Therapeutic Uses Abortifacient Agents Methotrexate |
Dermatologic Agents Etoposide Nucleic Acid Synthesis Inhibitors Asparaginase Anti-HIV Agents Antineoplastic Agents, Hormonal Hematologic Diseases Thioguanine Leukemia, Myeloid Abortifacient Agents, Nonsteroidal Glucocorticoids Idarubicin Neoplasms Aldesleukin Fludarabine |
