Inclusion Criteria

Concurrent Medication:

Allowed:

• Intravenous gammaglobulin. Pneumocystis prophylaxis according to published guidelines.

Patients must have the following:

• HIV infection.
• Parent or guardian must be available to give written informed consent.

Exclusion Criteria

Concurrent Medication:

Excluded:

• Zidovudine (AZT).
• Steroid dependency.

Excluded within 1 hour before and 4 hours after study drug administration:

• Drugs that might interfere with the absorption of study drug (H2 blockers, antacids, carafate, cholestyramine).
• Benzodiazepines.
• Alcohol-containing substances.

Concurrent Treatment:

Excluded:

• Requiring supplemental oxygen.

Patients with the following are excluded:

• Active opportunistic or serious bacterial infection.
• Lymphoid interstitial pneumonitis (LIP) and steroid dependent or requiring supplemental oxygen or have a pretreatment pa02 < 70 mm Hg.
• Pre-existing malignancies.

Prior Medication:

Excluded:

• Zidovudine (AZT) within 7 days prior to administration of study drug.

Excluded for at least 4 weeks prior to drug administration:

• Other approved or investigational antiretroviral agents. All other investigational agents. Biologic response modifiers (e.g., interferon) or immunomodulators. Immunosuppressive agents (including glucocorticoids). Coumadin and other anticoagulant medications.

Prior Treatment:

Excluded:

• Red blood cell transfusion within 4 weeks of study entry.

Patients may not have the following:

• Opportunistic or serious bacterial infection.

Zidovudine (AZT) > 7 days prior to administration of study drug.

Active alcohol or drug abuse.