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Comparator Study Evaluating Patient Preference Of Fluticasone Furoate Nasal Spray (FFNS) Versus Fluticasone Propionate Nasal Spray (FPNS)
This study has been completed.
Study NCT00539006   Information provided by GlaxoSmithKline
First Received: October 2, 2007   Last Updated: September 29, 2009   History of Changes
Study Type: Interventional
Study Design: Randomized, Double-Blind, Crossover Assignment
Condition: Seasonal Allergic Rhinitis
Interventions: Drug: fluticasone propionate
Drug: fluticasone furoate
Drug: placebo

  Participant Flow
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  Baseline Characteristics
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Reporting Groups
  Description
Fluticasone Furoate NS/Fluticasone Propionate NS Participants who received Fluticasone Furoate Nasal Spray (FFNS) 110 mcg every day (QD) followed by Fluticasone Propionate Nasal Spray (FPNS) 200 mcg QD for one week (treatment 1), followed by a 7 day washout period, and switched to one week of treatment 2, given FPNS 110 mcg QD, followed by FFNS 200 mcg QD.
Placebo - FF/FP Participants who received no active drug but believed they were following the Fluticasone Furoate/Fluticasone Propionate group.
Fluticasone Propionate NS/Fluticasone Furoate NS Participants who received Fluticasone Propionate Nasal Spray (FPNS)110 mcg QD followed by Fluticasone Furoate Nasal Spray (FFNS) 200 mcg QD for one week (treatment 1), followed by a 7 day washout period, and switched to one week of treatment 2, given FFNS 110 mcg QD, followed by FPNS 200 mcg QD.
Placebo - FP/FF Participants who received no active drug but believed they were following the Fluticasone propionate/Fluticasone Furoate group.

Baseline Measures
  Fluticasone Furoate NS/Fluticasone Propionate NS Placebo - FF/FP Fluticasone Propionate NS/Fluticasone Furoate NS Placebo - FP/FF Total
Number of Participants  
[units: participants]
96 95 95 91 377
Age  
[units: years]
Mean ± Standard Deviation
37.3 ± 13.89 42 ± 12.48 40.5 ± 12.29 39.7 ± 14.32 39.9 ± 13.33
Gender  
[units: participants]
         
Female 62 73 67 60 262
Male 34 22 28 31 115
Race/Ethnicity, Customized  
[units: participants]
         
American/African Heritage 8 8 10 8 34
American Indian or Alaska Native 0 0 0 0 0
Asian 0 3 1 1 5
Native Hawaiian or other Pacific Islander 0 0 1 0 1
White 88 84 82 80 334
African American/African-American Indian/Alaskan 0 0 0 1 1
African American/African Heritage & White 0 0 1 1 2



  Outcome Measures
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1.  Primary:   Comparison of Mean Change From Baseline in Daily Reflective Total Nasal Symptom Score (rTNSS) Over Treatment Periods of Active Drug Nasal Sprays Versus Placebos   [ Baseline, Treatment Period 1 (Days 1-7), Treatment Period 2 (Days 15-21) ]

2.  Primary:   Participant Preference of Fluticasone Furoate Nasal Spray (FFNS) Versus Fluticasone Propionate Nasal Spray (FPNS) Based on Scent/Odor   [ End of Crossover Period (Day 22) ]

3.  Secondary:   Participant Preference of Fluticasone Furoate Nasal Spray (FFNS) Versus Fluticasone Propionate Nasal Spray (FPNS) Based on Leaking Out of Nose/Down Throat   [ End of Crossover Period (Day 22) ]

4.  Secondary:   Participant Preference of Fluticasone Furoate Nasal Spray (FFNS) Versus Fluticasone Propionate Nasal Spray (FPNS) Based on Ease of Use   [ End of Crossover Period (Day 22) ]

5.  Secondary:   Participant Preference of Fluticasone Furoate Nasal Spray (FFNS) Versus Fluticasone Propionate Nasal Spray (FPNS) Based on Gentleness of Mist   [ End of Crossover Period (Day 22) ]

6.  Secondary:   Comparision of Mean Change From Baseline Over Treatment Periods in Daytime Reflective Total Nasal Symptom Scores (D r-TNSS) for Active Drug Nasal Sprays Versus Placebos   [ Baseline, Treatment Period 1 (Days 1-7), Treatment Period 2 (Days 15-21) ]

7.  Secondary:   Comparision of Mean Change From Baseline Over Treatment Periods in Nighttime Reflective Total Nasal Symptom Scores (N-rTNSS) for Active Drug Nasal Sprays Versus Placebos   [ Baseline, Treatment Period 1 (Days 1-7), Treatment Period 2 (Days 15-21) ]


  Serious Adverse Events
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  Other Adverse Events
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Certain Agreements:  
Principal Investigators are NOT employed by the organization sponsoring the study.
There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.


Limitations and Caveats
Limitations of the study, such as early termination leading to small numbers of participants analyzed and technical problems with measurement leading to unreliable or uninterpretable data
No text entered.  


Results Point of Contact:  
Name/Title: GSK Response Center
Organization: GlaxoSmithKline
phone: 866-435-7343


No publications provided


Responsible Party: GSK ( Study Director )
Study ID Numbers: FFU105924
Study First Received: October 2, 2007
Results First Received: November 14, 2008
Last Updated: September 29, 2009
ClinicalTrials.gov Identifier: NCT00539006     History of Changes
Health Authority: United States: Food and Drug Administration