Reporting Groups

	Description
Exenatide	Exenatide 5 mcg twice a day (BID) for 4-weeks followed by exenatide 10 mcg BID for 16-weeks.
Exenatide Plus Rosiglitazone	Exenatide 5 mcg BID + rosiglitazone 2 mg BID for 4-weeks followed by exenatide 10 mcg + rosiglitazone 4 mg BID for 16-weeks.
Rosiglitazone	Rosiglitazone 2 mg BID for 4-weeks followed by rosiglitazone 4 mgs BID for 16-weeks.

Baseline Measures

	Exenatide	Exenatide Plus Rosiglitazone	Rosiglitazone	Total
Number of Participants   [units: participants]	45	47	45	137
Age   [units: participants]
<=18 years	0	0	0	0
Between 18 and 65 years	36	37	36	109
>=65 years	9	10	9	28
Age   [units: years] Mean ± Standard Deviation	56.99 ± 9.71	54.63 ± 9.91	55.54 ± 10.71	55.70 ± 10.09
Gender   [units: participants]
Female	22	25	20	67
Male	23	22	25	70

1.  Primary:

Change in ASIiAUC During a Hyperglycemic Clamp Test.   [ 20 weeks ]

2.  Secondary:

Change in AUC for Glucose During a Meal Challenge Test (MCT).   [ Week 20 ]

3.  Secondary:

Change in Insulin Sensitivity Index as Measured by M-value.   [ Week 20 ]

4.  Secondary:

Change in Insulin AUC in the First Stage From Baseline to Endpoint.   [ Week 20 ]

5.  Secondary:

Change in Insulin iAUC From Baseline to Endpoint.   [ Week 20 ]

6.  Secondary:

Ratio (Value at Endpoint Divided by Value at Baseline) of AUC for Insulin During a Meal Challenge Test (MCT).   [ Week 20 ]

7.  Secondary:

Change in AUC for C-peptide During a Meal Challenge Test (MCT).   [ Week 20 ]

8.  Secondary:

Change in Incremental for Postprandial Glucose During a Meal Challenge Test (MCT).   [ Week 20 ]

9.  Secondary:

Change in Incremental for Postprandial Insulin During Meal Challenge Test (MCT).   [ Week 20 ]

10.  Secondary:

Change in Incremental for Postprandial C-peptide During Meal Challenge Test (MCT).   [ Week 20 ]

11.  Secondary:

Change in HbA1c   [ Week 20 ]

12.  Secondary:

Change in Fasting Serum Glucose Concentration.   [ Week 20 ]

13.  Secondary:

Change in Fasting C-peptide   [ Week 20 ]

14.  Secondary:

Change in Fasting Insulin   [ Week 20 ]

15.  Secondary:

Change in Fasting Proinsulin   [ Week 20 ]

16.  Secondary:

Change in Body Weight   [ Week 20 ]

17.  Secondary:

Change in Fasting Total Cholesterol.   [ Week 20 ]

18.  Secondary:

Change in Fasting HDL Cholesterol   [ Week 20 ]

19.  Secondary:

Change in Fasting LDL Cholesterol   [ Week 20 ]

20.  Secondary:

Change in Fasting Triglycerides   [ Week 20 ]

21.  Secondary:

Change in Percent Body Fat During a Meal Challenge Test (MCT)   [ 20 weeks ]

22.  Secondary:

Change in Body Fat Mass During a Meal Challenge Test (MCT)   [ 20 weeks ]

23.  Secondary:

Change in Lean Body Mass During a Meal Challenge Test (MCT)   [ 20 weeks ]

24.  Secondary:

Change in Waist Circumference   [ 20 weeks ]

25.  Secondary:

Change in Hip Circumference   [ 20 weeks ]

26.  Secondary:

Change in Waist-to-hip Ratio   [ 20 weeks ]

27.  Secondary:

Incidence of Hypoglycemia Events   [ 20 weeks ]

28.  Secondary:

Hypoglycemia Rate Per 30 Days Per Patient   [ 20 weeks ]

29.  Secondary:

Pedal Edema Score   [ 20 weeks ]