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The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2014 by Central South University
Sponsor:
Information provided by (Responsible Party):
Chang-Qing Gao, Central South University
ClinicalTrials.gov Identifier:
NCT02049658
First received: January 26, 2014
Last updated: January 28, 2014
Last verified: January 2014

January 26, 2014
January 28, 2014
January 2014
August 2014   (final data collection date for primary outcome measure)
sensitivity and specificity of the sniff dogs as a tool in diagnosing tumors [ Time Frame: 12 months ] [ Designated as safety issue: No ]
The results that obtained from the dogs will be compared with these of the pathological examinations. Sensitivity = the No. of patients identified by the dogs as cancers / the No. of patients suffering from cancer confirmed by pathological examination. Specificity = No. of subjects signaled by the dog as non-cancers / No. of subjects confirmed by pathological examination as non-cancer subjects.
Same as current
Complete list of historical versions of study NCT02049658 on ClinicalTrials.gov Archive Site
behavior patterns of the sniff dogs to different diseases [ Time Frame: 12 months ] [ Designated as safety issue: No ]
The behavior (lying before the tank for positive, neglecting the tanks) of the dog will be recorded and compared with the results of the pathological examination.
Same as current
the substances used for identifying tumors by the sniff dogs [ Time Frame: 12 months ] [ Designated as safety issue: No ]
GCMS etc will be used to compare the volatile compounds between the sera from cancers patients and the from non-cancer subjects, the suspected VOCs will be tested by the dog for conformation.
Same as current
 
The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients
The Sensitivity and Specificity of Sniff Dog as a Tool in Diagnosing the Suspected Tumor Patients

Previous studies have demonstrated that sniff dogs can identify cancer patients from healthy subjects through sniffing exhaled breath air or blood or serum or urine or feces. It is hypothesized that sniff dogs may be used as a tool in identifying cancer patients in the high risk population or suspected patients. Trained dogs will sniff serum from participants who are suspected to suffer from tumor by their physicians and not yet but will be diagnosed by pathological examination.The results will be compared with the outcome of the pathological examination.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

Serum

Non-Probability Sample
  • Healthy volunteers who have been examined by the currently used procedures and find to be without tumors.
  • Patients in the breast surgery, thoracic surgery, gynecological and neurosurgery departments with lesions with characteristics of tumors
Neoplasia
Not Provided
  • Healthy volunteers
    Healthy volunteers measured by currently used healthy screening procedures
  • Suspected breast cancer subjects
    Suspected breast cancer subjects without pathological examination yet but will have it soon
  • Suspected lung cancer subjects
    Suspected lung cancer subjects without pathological examination yet but will have it soon
  • Suspected neurological tumor subjects
    Suspected neurological tumor subjects without pathological examination yet but will have it soon
  • Suspected patients with gynecological tumor
    Suspected subjects with gynecological tumors without pathological examination yet but will have it soon
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
2000
August 2014
August 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy volunteers who have been examined by the currently used procedures and find to be without tumors.
  • Patients in the breast surgery, thoracic surgery, gynecological and neurosurgery departments with lesions with characteristics of tumors

Exclusion Criteria:

  • Patients who have had pathological results
Both
1 Year and older
Yes
Contact: Chang-Qing Gao, MD PhD 86 188 7486 9488 cgao851@126.com
Contact: Ya-Qin Wang, MD PhD 86 15274810930 wdove.bb@163.com
China
 
NCT02049658
Xiang-Ya 0003, XY 0003
No
Chang-Qing Gao, Central South University
Chang-Qing Gao
Not Provided
Principal Investigator: Chang-Qing Gao, MD PhD Central South University
Central South University
January 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP