Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2013 by The Third Xiangya Hospital of Central South University
Sponsor:
Collaborator:
Xiangya Hospital of Central South University
Information provided by (Responsible Party):
Yuan Hong, The Third Xiangya Hospital of Central South University
ClinicalTrials.gov Identifier:
NCT02023450
First received: December 23, 2013
Last updated: NA
Last verified: January 2013
History: No changes posted

December 23, 2013
December 23, 2013
December 2013
June 2014   (final data collection date for primary outcome measure)
HMGB1 level [ Time Frame: 14 days ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
  • TNF、IL-1Β、IL-6、Pro-BNP and CRP level [ Time Frame: 14 days ] [ Designated as safety issue: No ]
  • NYHA/WHO functional class [ Time Frame: 14 days ] [ Designated as safety issue: No ]
  • Brog respiration class [ Time Frame: 14 days ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension
Not Provided

Study Rationale:There is recent evidence that HIV protease inhibitors (HIV-PI) can improve pulmonary hemodynamics in experimental models of pulmonary arterial hypertension (PAH). There is also experimental evidence that both TLR4 and high mobility group box 1 (HMGB1) participate in the pathogenesis of experimental pulmonary hypertension. A recent high throughput screen for inhibitors of HMGB1 induced macrophage activation yielded HIV-protease inhibitors (PIs) as potent inhibitors of HMGB1 induced cytokine production. Based on the experimental evidence we propose a trial to determine whether HIV-PIs will alter the pathobiology of PAH.

Study Objectives:The main objective of this study is to determine whether saquinavir and ritonavir (SQV+RIT) which have a well-characterized safety profile in humans will reduce bio markers of inflammation and pulmonary artery pressures in patients with PAH.

Study Hypothesis:We hypothesize that the HIV-PI, SQV+RIT, will reduce circulating parameters of inflammation including HMGB1, IL1-beta, IL-6, IL-8, IL-10, TNF-alpha and CRP. Our end points will be changes in these parameters from baseline over the duration of the study.We hypothesize that treatment with SQV+RIT will reduce pulmonary artery(PA) pressure of patients with PAH as measured by echocardiography.

Study Design:This is a single center open label phase 0 study to evaluate the effect of SQV +RIT in patients with IPAH. Subjects with IPAH(N=20) will be enrolled into a study, which will be divided into 3 cohorts and entail the administration of HIV protease inhibitors in two doses. The first cohort (n=3) will receive a starting dose of SQV 0.3 mg/kg daily in combination with RIT 0.03 mg/kg daily. If the first dose is well-tolerated, the second cohort (n= 3 ) with IPAH will be given doses of SQV 3 mg/kg and RIT 0.3 mg/kg daily. If the second dose is well-tolerated, the last cohort (n= 14 ) with IPAH will be given doses of SQV 15 mg/kg and RIT 1.5 mg/kg daily.

Not Provided
Interventional
Phase 0
Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Pulmonary Arterial Hypertension
  • Drug: saquinavir and ritonavir
    micro and low dose
  • Drug: saquinavir and ritonavir
    standard dose
  • Experimental: micro/low dose saquinavir and ritonavir
    To determine if micro dose and low dose SQV+RIT mediates parameters of chronic inflammation in patients with IPAH.
    Intervention: Drug: saquinavir and ritonavir
  • Experimental: standard dose saquinavir and ritonavir
    To determine if short-term use of SQV+RIT reduces parameters of chronic inflammation and PA pressure of IPAH based on echocardiographic parameters. Safety issue also evaluated at the same time.
    Intervention: Drug: saquinavir and ritonavir
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
20
July 2014
June 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 18-60
  • Idiopathic pulmonary arterial hypertension
  • Evidence of a personally signed and dated informed consent document indicating that the subject (or a legally acceptable representative) has been informed of all pertinent aspects of the study
  • Had the diagnosis of PH confirmed by a cardiac catheterization:Mean pulmonary artery pressure (mPAP) ≥ 25 mm Hg (at rest)
  • Stable PAH therapy for at least 3 months

Exclusion Criteria:

  • Baseline systemic hypotension, defined as MAP less than 50 mmHg
  • Required intravenous inotropes within 30 days prior to study participation
  • Has uncontrolled systemic hypertension as evidenced by sitting systolic blood pressure >160 mm Hg or sitting diastolic blood pressure >100 mm Hg at screening
  • Has a history of portal hypertension or chronic liver disease, including cirrhosis, chronic alcoholism, hepatitis B and/or hepatitis C (with evidence of recent infection and/or active virus replication) defined as moderate to severe hepatic impairment (Child-Pugh Class B-C)
  • Has chronic renal insufficiency as defined by serum creatinine >2.5 mg/dL at screening or requires dialysis support
  • Has a hemoglobin concentration <9 g/dL at Screening
  • History of atrial septostomy
  • Repaired or unrepaired congenital heart disease (CHD)
  • Pericardial constriction
  • Restrictive or congestive cardiomyopathy
  • Left ventricular ejection fraction 40% by multiple gated acquisition scan (MUGA), angiography or echocardiography
  • Symptomatic coronary disease with demonstrable ischemia
  • Other severe acute or chronic medical or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study
  • Has a psychiatric, addictive or other disorder that compromises the ability to give informed consent for participating in this study. This includes subjects with a recent history of abusing alcohol or illicit drugs 30 days prior to study screening Day 1 and for the duration of the study
  • Poorly controlled asthma defined by active wheezing and/or cough with FEV1 < 70% predicted, responsive to inhaled BD (>15% increase in FEV1 with BD)
  • Clinically significant intercurrent illness (including lower respiratory tract infection) or clinically significant surgery within 4 weeks before the administration of study drug
  • History of hypersensitivity or idiosyncratic reaction to drugs from multiple drug classes
  • Receipt of an investigational product or device, or participation in a drug research study within a period of 15 days (or 5 half lives of the drug, whichever is longer) before the first dose of study drug
  • Blood loss or blood donation >550mL within 90 days or plasma donation >500 mL within 14 days before administration of study drug;
  • Patients with a QTc interval > 450 msec
  • Has diabetes mellitus as defined by symptoms of hyperglycemia and serum fasting plasma glucose level≥7.0mmol/l or casual plasma glucose≥11.1mmol/l at screen
  • Has a hyperlipidemia as TC≥6.22 mmol/L, LDL-C ≥4.14 mmol/L or TG ≥2.26 mmol/L
  • History of crohn's disease, ulcerative colitis (UC) and etc. Inflammatory bowel disease (IBD)
  • Male patients who are not willing to take contraceptive measures during the study
  • Patients who are taking certain other medication will need to be evaluated for possible exclusion based on the potential for adverse drug interactions
Both
18 Years to 60 Years
No
Contact: Li Ying, MD 0086-13787184360 lydia0312@csu.edu.cn
China
 
NCT02023450
HPI-PAH-0
Yes
Yuan Hong, The Third Xiangya Hospital of Central South University
The Third Xiangya Hospital of Central South University
Xiangya Hospital of Central South University
Not Provided
The Third Xiangya Hospital of Central South University
January 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP