Postprandial VLDL-TG Metabolism

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified October 2013 by University of Aarhus
Sponsor:
Information provided by (Responsible Party):
Esben Søndergaard, University of Aarhus
ClinicalTrials.gov Identifier:
NCT01961024
First received: September 27, 2013
Last updated: October 10, 2013
Last verified: October 2013

September 27, 2013
October 10, 2013
January 2014
January 2016   (final data collection date for primary outcome measure)
VLDL-TG storage in adipose tissue [ Time Frame: 3 hours ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01961024 on ClinicalTrials.gov Archive Site
18F-THA fractional storage [ Time Frame: 6 Hours ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Postprandial VLDL-TG Metabolism
Postprandial VLDL-TG Metabolism

In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:

specimen of muscle specimen of adipose tissue

Non-Probability Sample

Males with diabetes from the department´s out-patient clinic. Control group of healthy volunteers

Type 2 Diabetes
Not Provided
  • Type 2 diabetic men
  • Age- and weight-matched controls
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
20
Not Provided
January 2016   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Written consent

Exclusion Criteria:

  • Known diseases
  • Alcohol abuse
  • Smoker
  • Regular use of medicine
Male
30 Years to 70 Years
Yes
Contact: Esben Søndergaard, MD, PhD +4578461631 esbens@dadlnet.dk
Denmark
 
NCT01961024
ES-0006
Yes
Esben Søndergaard, University of Aarhus
University of Aarhus
Not Provided
Not Provided
University of Aarhus
October 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP