Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study (IP4)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
Wellcome Trust
National Institute for Health Research, United Kingdom
Information provided by (Responsible Party):
Harry Hemingway, University College, London
ClinicalTrials.gov Identifier:
NCT01937065
First received: July 2, 2013
Last updated: September 3, 2013
Last verified: September 2013

July 2, 2013
September 3, 2013
January 2012
December 2013   (final data collection date for primary outcome measure)
Hazard ratios for the associations between social deprivation and initial presentation of 12 cardiovascular diseases. [ Time Frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years ] [ Designated as safety issue: No ]

Associations studied:

  • overall
  • by sex
  • by age group
  • in high risk groups (smokers, hypertensive disease, obese, diabetic, depression)
  • before and after the introduction of the Quality and Outcomes Framework in England
Same as current
Complete list of historical versions of study NCT01937065 on ClinicalTrials.gov Archive Site
Lifetime cumulative incidence per quintile of social deprivation [ Time Frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years ] [ Designated as safety issue: No ]
Same as current
Heterogeneity in associations across 12 cardiovascular diseases using the Tau-squared statistic and I-square statistics. [ Time Frame: Followed for the duration of general practice registration between January 1997 and March 2010, an expected average of 5 years ] [ Designated as safety issue: No ]
Same as current
 
Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
Not Provided

Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.

This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).

Observational
Observational Model: Cohort
Time Perspective: Retrospective
Not Provided
Not Provided
Non-Probability Sample

1,93 million patients registered in Clinical Practice Research Datalink (CPRD) practices

  • Abdominal Aortic Aneurysm
  • Coronary Heart Disease NOS
  • Unheralded Corronary Death
  • Intracerebral Haemorrhage
  • Heart Failure
  • Ischemic Stroke
  • Myocardial Infarction
  • Stroke
  • Peripheral Arterial Disease
  • Stable Angina Pectoris
  • Subarachnoid Haemorrhage
  • Transient Ischemic Attack
  • Unstable Angina
  • Cardiac Arrest, Sudden Cardiac Death
Other: No treatment
No treatment
Intervention: Other: No treatment
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
1937360
December 2014
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
  • 30 years or older
  • Recorded sex
  • Free of symptomatic CVD at inclusion.

Exclusion Criteria:

  • Pregnant women in the 6 months before the eligibility date
Both
30 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT01937065
12_153R_IP4
Yes
Harry Hemingway, University College, London
University College, London
  • Wellcome Trust
  • National Institute for Health Research, United Kingdom
Not Provided
University College, London
September 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP