Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Enrique Caballero, Joslin Diabetes Center
ClinicalTrials.gov Identifier:
NCT01926938
First received: August 19, 2013
Last updated: August 20, 2013
Last verified: August 2013

August 19, 2013
August 20, 2013
May 2003
January 2013   (final data collection date for primary outcome measure)
markers of endothelial activation, coagulation and inflammation [ Time Frame: cross sectional evaluation ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01926938 on ClinicalTrials.gov Archive Site
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Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes
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Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with diabetes. Endothelial function and vascular reactivity are impaired not only in white adults with type 2 diabetes but also in those at risk for the disease by virtue of having impaired glucose tolerance or parental history of type 2 diabetes. Whether this finding is applicable to hispanics is not known. The investigators plan to assess the endothelial function and vascular reactivity in young Hispanic adults at risk of developing type 2 diabetes by virtue of being obese and belonging to a minority population.

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Observational
Time Perspective: Cross-Sectional
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Probability Sample

Young Latino adults with and without family history of type 2 diabetes

  • Obesity
  • Insulin Resistance
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  • adults at risk
    Latino adults with family history of type 2 diabetes
  • controls
    Latino adults without family history of type 2 diabetes and normal glucose tolerance
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
44
January 2013
January 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Group 1:

    1. Age between 18-40 years;
    2. Hispanic (we will consider a subject being Hispanic if both parents are reported as Hispanics when asked the following question: "What ethnic group do you consider that you belong to?");
    3. History of type 2 diabetes in one or both parents;
    4. BMI above 27;
    5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.

Group 2:

  1. Age between 18-40 years;
  2. Hispanic (same criteria as above );
  3. No history of type 2 diabetes in any first degree relative;
  4. BMI under 25;
  5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.

Exclusion Criteria:

  • diabetes, glucose intolerance, pregnancy, smoking, cardiovascular disease, uncontrolled hypertension, renal disease, proteinuria, cancer, infectious diseases, severe GI diseases, lung disease, electrolyte abnormalities, anemia, endocrine disorders, severe dyslipidemia, peripheral vascular disease, medications: beta-blockers, any diuretic, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, niacin, glucocorticoids, any antineoplastic agent, antibiotics, psychoactive agents, bronchodilators or insulin.
Both
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01926938
CHS#: 03-30
Yes
Enrique Caballero, Joslin Diabetes Center
Joslin Diabetes Center
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Principal Investigator: Enrique Caballero, MD Joslin Diabetes Center
Joslin Diabetes Center
August 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP