Positron Emission Tomography of Infection and Vasculitis (PETU)

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2013 by Turku University Hospital
Sponsor:
Information provided by (Responsible Party):
Anne Roivainen, Turku University Hospital
ClinicalTrials.gov Identifier:
NCT01878721
First received: June 10, 2013
Last updated: June 14, 2013
Last verified: June 2013

June 10, 2013
June 14, 2013
January 2011
December 2013   (final data collection date for primary outcome measure)
Detection of infection or vasculitis in PET images [ Time Frame: within 1 week after starting the treatment ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01878721 on ClinicalTrials.gov Archive Site
Standardized uptake value of PET imaging agent at the site of infection or vasculitis [ Time Frame: within 1 week after starting the treatment ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Positron Emission Tomography of Infection and Vasculitis
Positron Emission Tomography of Infection and Vasculitis (PETU)

The purpose of this study is to evaluate the value of positron emission tomography/computed tomography in various inflammatory conditions caused by bacterial infection or vasculitis. Glucose analog FDG is sensitive to detect inflammation foci but we hypothesize that other imaging agents such as PK11195 and Ga-citrate may have added value in certain applications.

The purpose of this study is to evaluate the value of PET/CT in various inflammatory conditions caused by bacterial infection or vasculitis. Our aim is to:

  1. investigate whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET/CT and 68Ga-(Gallium-68) citrate PET/CT enable the early and accurate detection of metastatic infection foci in Staphylococcus aureus bacteremia.
  2. study the usefulness of FDG PET/CT in detection of endovascular infection in bacteremia caused by Salmonella spp.
  3. find an optimal FDG PET/CT protocol for detection of infectious endocarditis and metastatic infection foci related to endocarditis.
  4. study the value of FDG PET/CT in the diagnosis of infection of pacemaker or implantable cardioverter defibrillator.
  5. investigate the usefulness of FDG PET/CT, 68Ga-citrate PET/CT, and 11C- (carbon-11) translocator protein ligand (PK11195) PET/CT in diagnosis of vasculitis and in imaging of the magnitude of the vascular changes.
Observational
Observational Model: Case-Only
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Patients of Turku University Hospital

  • Infection
  • Vasculitis
Radiation: PET/CT
positron emission tomography/computed tomography
  • Staphylococcus aureus bacteremia
    PET/CT in patients with Staphylococcus aureus bacteremia
    Intervention: Radiation: PET/CT
  • Salmonella spp. bacteremia
    PET/CT in patients with Salmonella spp. bacteremia
    Intervention: Radiation: PET/CT
  • Endocarditis
    PET/CT in patients with infective endocarditis
    Intervention: Radiation: PET/CT
  • Pacemaker infection
    PET/CT in patients with pacemaker infection
    Intervention: Radiation: PET/CT
  • Vasculitis
    PET/CT in patients with vasculitis
    Intervention: Radiation: PET/CT
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
117
December 2014
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

Adults with

  • Staphylococcus aureus bacteremia or
  • Salmonella spp. bacteremia or
  • infective endocarditis or
  • infection of pacemaker or implantable cardioverter defibrillator or
  • vasculitis

Exclusion Criteria:

  • underage, pregnant, breastfeeding, handicapped or prisoner
Both
18 Years and older
No
Contact: Ulla Hohenthal, MD, PhD ulla.hohenthal@tyks.fi
Contact: Laura Pirilä, MD, PhD laura.pirila@tyks.fi
Finland
 
NCT01878721
14824
No
Anne Roivainen, Turku University Hospital
Turku University Hospital
Not Provided
Not Provided
Turku University Hospital
June 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP