Myocardial Ischemia in Non-obstructive Coronary Artery Disease (MicroCAD)

This study is currently recruiting participants.
Verified May 2013 by University of Bergen
Sponsor:
Collaborator:
Haukeland University Hospital
Information provided by (Responsible Party):
Mai Tone Lønnebakken, University of Bergen
ClinicalTrials.gov Identifier:
NCT01853527
First received: May 7, 2013
Last updated: May 10, 2013
Last verified: May 2013

May 7, 2013
May 10, 2013
April 2013
December 2014   (final data collection date for primary outcome measure)
Presence of myocardial ischemia by contrast stress echocardiography [ Time Frame: 15 minutes, during contrast stress echocardopgraphy ] [ Designated as safety issue: No ]
Presence of delayed myocardial contrast enhancement during stress echocardiography
Same as current
Complete list of historical versions of study NCT01853527 on ClinicalTrials.gov Archive Site
Extent of myocardial ischemia by contrast stress echocardiography [ Time Frame: 15 minutes, during contrast stress echocardiography ] [ Designated as safety issue: No ]
Numbers of left ventricular segments with delayed contrast enhancement during stress echocardiography
Same as current
Not Provided
Not Provided
 
Myocardial Ischemia in Non-obstructive Coronary Artery Disease
Myocardial Ischemia in Non-obstructive Coronary Artery Disease

The aim of the study is to assess presence of myocardial ischemia by contrast stress echocardiography in patients with symptomatic non-obstructive coronary artery disease (CAD) by CT-coronary angiography, and the clinical, vascular, biochemical and genetic markers of myocardial ischemia in such patients.

Non-obstructive coronary artery disease (CAD) is particularly common in women and associated with reduced quality of life and increased cardiovascular morbidity and mortality. The project will recruit patients with angina pectoris and non-obstructive CAD by CT- coronary angiography for further imaging with contrast stress echocardiography for diagnosis of myocardial ischemia. Better characterization of patients with symptomatic non-obstructive CAD due to myocardial ischemia will be done by vascular assessment by tonometry, biochemical and genetic markers as well as quality of life questionnaire. This interdisciplinary project is expected to add new knowledge to the impact of multimodality cardiac imaging in improving diagnosis in patients with symptomatic non-obstructive CAD.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Blood and urin test for biobank

Probability Sample

The study population include 132 patients with symptomatic angina pectoris and non-obstructive coronary artery disease detected by CT-coronary angiography

  • Coronary Atherosclerosis
  • Myocardial Ischemia
Not Provided
Angina pectoris, non-obstructive CAD
Contrast stress echocardiography will be performed in patients with angina pectoris and non-obstructive CAD on CT-angiography to detect presence of myocardial ischemia
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
132
December 2014
December 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age >30 years
  • Chest pain and or functional dyspnoea with a duration > 6 months
  • Non-obstructive coronary artery disease detected by CT coronary angiography

Exclusion Criteria:

  • Significant coronary artery stenosis or normal coronary arteries by CT coronary angiography
  • Unstable coronary artery disease
  • Significant valvular heart disease
  • Mechanical valve prosthesis
  • Significant arrhythmia
  • Severly reduced pulmonary function (GOLD 3-4)
  • Known allergy to ultrasound contrast agents
  • Pregnancy
  • Inability to sign informed consent to participate
  • Other severe disease
Both
30 Years and older
No
Contact: Mai Tone Lønnebakken, MD phd +47 55972220 mai.lonnebakken@k2.uib.no
Norway
 
NCT01853527
2012/2167b
No
Mai Tone Lønnebakken, University of Bergen
University of Bergen
Haukeland University Hospital
Principal Investigator: Mai Tone Lønnebakken, MD, phd University of Bergen
University of Bergen
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP