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Effect of Ginseng on Glycemic Control

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
St. Michael's Hospital, Toronto
ClinicalTrials.gov Identifier:
NCT01841229
First received: April 23, 2013
Last updated: May 22, 2013
Last verified: May 2013

April 23, 2013
May 22, 2013
October 2012
May 2013   (final data collection date for primary outcome measure)
Glycated hemoglobin (HbA1c) [ Time Frame: 1month ] [ Designated as safety issue: No ]
HbA1c [ Time Frame: 1month ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT01841229 on ClinicalTrials.gov Archive Site
  • Fasting blood glucose [ Time Frame: 1month ] [ Designated as safety issue: No ]
  • Fasting plasma insulin [ Time Frame: 1 month ] [ Designated as safety issue: No ]
  • Homeostasis model assessment of insulin resistance (HOMA-IR) [ Time Frame: 1 month ] [ Designated as safety issue: No ]
fasting glucose, fasting insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR) [ Time Frame: 1month ] [ Designated as safety issue: No ]
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Effect of Ginseng on Glycemic Control
Effect of Ginseng on Glycemic Control: A Systematic Review and Meta-analysis of Controlled Trials to Provide Evidence-based Clinical Recommendations

Ginseng (American ginseng, Asian ginseng, Korean ginseng etc) is expected to show positive hypoglycemic effects, including improvements in glycated blood proteins[HbA1c], fasting glucose, fasting insulin, and the homeostasis model assessment of insulin resistance [HOMA-IR]).

Ginseng has demonstrated to have significant hypoglycemic effect. Its major pharmacological component is considered to be ginsenosides. Several trials have been undertaken in diabetes some of which have demonstrated advantages in glycemic control in both diabetic as well as non diabetic individuals although clinical consistency of results is lacking.The lack of high quality data in this area to support diabetes recommendations represents an urgent call for stronger evidence. A systematic review and meta-analysis of controlled trials remains the "Gold Standard" of evidence for recommendations and clinical guidelines development. Therefore, investigators will conduct a systematic review and meta-analyses of controlled trials to assess the effect of ginseng on glycemic control.

Observational
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Probability Sample

Diabetic (type 1 & type 2) Pre-diabetic Hypertensive Healthy

  • Impaired Glucose Tolerance
  • Diabetes
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Shishtar E, Sievenpiper JL, Djedovic V, Cozma AI, Ha V, Jayalath VH, Jenkins DJ, Meija SB, de Souza RJ, Jovanovski E, Vuksan V. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PLoS One. 2014 Sep 29;9(9):e107391. doi: 10.1371/journal.pone.0107391. eCollection 2014.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
770
May 2013
May 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Dietary trials in humans
  • Randomized treatment allocation
  • 1 month
  • Suitable control
  • Viable endpoint data

Exclusion Criteria:

  • Non-human studies
  • Non-randomized treatment allocation
  • <1 month
  • Lack of a suitable control
  • No viable endpoint data
Both
Not Provided
Yes
Contact information is only displayed when the study is recruiting subjects
Canada
 
NCT01841229
MetaG
Yes
St. Michael's Hospital, Toronto
St. Michael's Hospital, Toronto
Not Provided
Principal Investigator: Vladimir Vuksan, PhD St. Michael's Hospital, Toronto
St. Michael's Hospital, Toronto
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP