Autonomic Dysfunction in Resistant Hypertension (RH)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Valéria Nasser Figueiredo, University of Campinas, Brazil
ClinicalTrials.gov Identifier:
NCT01833429
First received: April 5, 2013
Last updated: April 12, 2013
Last verified: February 2012

April 5, 2013
April 12, 2013
September 2011
November 2012   (final data collection date for primary outcome measure)
evaluation of the autonomic function in resistant hypertensive patients [ Time Frame: 10 months ] [ Designated as safety issue: No ]

The autonomic nervous system can be assessed by the heart rate variability. Variations in heart rate variability are normally observed in association with diurnal rhythms and blood pressure changes. The heart rate variability parameters are different in many studies, although the consensus is that lower values of the indices of vagal as well as high indices of sympathetic functions are associated prospectively with death and disability.

In humans, the disturbances of the circadian rhythms of heart rate variability and blood pressure have been intensively studied, mainly due to the increased cardiovascular death reported during the morning hours

Same as current
Complete list of historical versions of study NCT01833429 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Autonomic Dysfunction in Resistant Hypertension
Circadian Autonomic Disturbances in Resistant Hypertension With and Without White-coat Phenomenon

The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.

All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.

Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.

Observational [Patient Registry]
Observational Model: Cohort
10 Months
Not Provided
Probability Sample

Forty-four resistant hypertension subjects, regularly followed up at the cardiovascular clinical pharmacology out-patients' clinic, and who complied with pharmacological prescription for hypertension, were recruited to participate in this transversal and observational study.

Hypertension, Resistant to Conventional Therapy
Not Provided
Resistant Hypertension
The current definition of resistant hypertension (RH) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications and those whose BP is controlled when using four or more antihypertensive medications

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
44
December 2012
November 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • resistant hypertensive patients

Exclusion Criteria:

  • White-coat hypertension
  • obstructive sleep apnea
Both
30 Years to 60 Years
No
Contact information is only displayed when the study is recruiting subjects
Brazil
 
NCT01833429
907/2011
No
Valéria Nasser Figueiredo, University of Campinas, Brazil
University of Campinas, Brazil
Not Provided
Not Provided
University of Campinas, Brazil
February 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP