Metabolomics Fingerprinting and Metabolic Dynamis After HIV Infection

This study is currently recruiting participants.
Verified March 2014 by Sichuan Academy of Medical Sciences
Sponsor:
Information provided by (Responsible Party):
Sichuan Academy of Medical Sciences
ClinicalTrials.gov Identifier:
NCT01828268
First received: April 5, 2013
Last updated: March 19, 2014
Last verified: March 2014

April 5, 2013
March 19, 2014
March 2013
March 2019   (final data collection date for primary outcome measure)
Dyslipidemia [ Time Frame: Dyslipidemia events from admission to discharge(Up to 6 months) ) ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01828268 on ClinicalTrials.gov Archive Site
Lipoatrophy [ Time Frame: Lipoarophy events from admission to discharge (up to 6 months) ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Metabolomics Fingerprinting and Metabolic Dynamis After HIV Infection
Metabolic Fingerprintings and Metabolic Dynamics After HIV Infection:Impact of Metabolic Changes and Anti-Retroviral Therapy, Life Style and Clinical Conditions

The purpose of this plot study is to find out the relationship between metabolic changes and anti-retroviral therapy (ART), life style and clinical conditions of HIV-infected patients using nuclear magnetic resonance (NMR) based systems biology approach and metabolomics methodology.

Since the clinical application of anti-retroviral therapy (ART) in 1997, the life expectancy of HIV infected patients has been prolonged greatly. However,side effects of ART including metabolic abnormalities have become the main factors influencing patients' quality of life. Among which the abnormal lipid metabolism plays an important role. Meanwhile, metabolic conditions differ from patients applying to different combinations of ART drugs,life style and clinical conditions.

Metabolomics can measure the dynamic metabolic responses of the body to stimuli or modifications. Using nuclear magnetic resonance (NMR) as tools can systematically analyse the process of lipid metabolism. Metabolomics fingerprinting can be defined as the complete complement of small molecule (< 1500 Da) metabolites found in a specific cell, body fluid, organ or organism.

Therefore, the study of the impact of metabolic changes and anti-retroviral therapy (ART), life style and clinical conditions is of importance in enhancing the adherence and improving the clinical outcomes of HIV infected patients.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

Plasma from peripheral blood

Non-Probability Sample

Recruit 100 HIV-infected individuals from community HIV Clinic and/or Transmitted Disease Hospital of Chengdu

HIV
Not Provided
HIV infectors
100 confirmed HIV-1 infected patients who meet inclusion criteria.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
100
March 2020
March 2019   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Clinical diagnosis of HIV infection

Exclusion Criteria:

  • Pregnancy
  • Individual who is participating in other trial(s)
Both
18 Years to 60 Years
Yes
Contact: Hua JIANG, PhD +86-28-88424391 hua.jiang@traumabank.org
Contact: Bing CAI, Master +86-28-88424391
China
 
NCT01828268
META-HA-001-2013
Yes
Sichuan Academy of Medical Sciences
Sichuan Academy of Medical Sciences
Not Provided
Study Chair: Hua JIANG, PhD 3Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, East Branch, Metabonomics and Multidisciplinary Laboratory
Principal Investigator: Jin PENG, Master 3Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, East Branch, Metabonomics and Multidisciplinary Laboratory
Sichuan Academy of Medical Sciences
March 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP