Investigating Variation in Hospital Acute Coronary Syndrome Outcomes

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Oras Alabas, University of Leeds
ClinicalTrials.gov Identifier:
NCT01819103
First received: March 23, 2013
Last updated: April 3, 2013
Last verified: April 2013

March 23, 2013
April 3, 2013
March 2011
February 2013   (final data collection date for primary outcome measure)
Mortality [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01819103 on ClinicalTrials.gov Archive Site
Drug Adherence [ Time Frame: 12 month ] [ Designated as safety issue: Yes ]
Same as current
Health related quality of life assessement [ Time Frame: 12 month ] [ Designated as safety issue: No ]
Same as current
 
Investigating Variation in Hospital Acute Coronary Syndrome Outcomes
Evaluation of the Methods and Management of Acute Coronary Events-4: Investigating Variation in Hospital Acute Coronary Syndrome Outcomes

To investigate the causes of hospital variation in outcomes from acute coronary syndromes in England and develop recommendations for improving patient care.

Over the last few years the chance of dying from a heart attack in England and Wales has reduced dramatically. Even so, there remain huge differences in mortality between hospitals. For example, up to a third of patients with a heart attack who attend hospitals in England are more likely to die than would be expected. That is, the type of treatment and the risk of death depend upon where a patient lives and which hospital they attend. In part, the variation in death may be due to the services available at the hospital or to factors such as socioeconomic deprivation. It may also relate to other factors such as depression, cardiac rehabilitation, patient experience of hospital care and whether patients take their medication after discharge from hospital.

Notably, the challenges posed by poor drug adherence to secondary prevention medications are recognised by the World Health Organisation as the highest area of priority for improving individual health throughout the world. In addition, Patient Reported Outcome Measures (PROMs) are set to be the cornerstone of the evaluation of patient experiences of National Health Service quality of care.

Using statistical approaches that include measures of quality of life, we propose to examine data about heart attacks in England and investigate the 'postcode lottery of care'. Our aim, using regional data about heart attacks is to identify and measure the effects of hospital care. This research will identify hospital qualities that promote improved patient care. In doing so, best practice will be highlighted and healthcare policy changed so that all patients will have an equal chance of surviving a heart attack.

Observational [Patient Registry]
Observational Model: Cohort
Time Perspective: Prospective
12 Months
Retention:   Samples With DNA
Description:

Blood, Urine

Non-Probability Sample

A total of 5555 consented patients were recruited from acute Trusts in England.

Acute Myocardial Infarction
Not Provided
Acute myocardial infarction
Drug Adherence
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
5555
March 2013
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

Age > 18 years, both sexes, acute admission to the acute Trust with suspected acute coronary syndrome (ACS).

Exclusion Criteria:

Patients at a terminal stage of any illness, and those in whom follow up would be inappropriate or impractical.

Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT01819103
12/WM/0431
No
Oras Alabas, University of Leeds
University of Leeds
Not Provided
Principal Investigator: Chris P Gale, PhD University of Leeds
University of Leeds
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP