Comparison of Efficacy of Ivabradine Versus Metoprolol (IMAGE)

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified October 2013 by Phramongkutklao College of Medicine and Hospital
Sponsor:
Collaborator:
Phramongkutklao College of Medicine and Hospital
Information provided by (Responsible Party):
Col. Suthee Panichkul, Phramongkutklao College of Medicine and Hospital
ClinicalTrials.gov Identifier:
NCT01755663
First received: December 19, 2012
Last updated: October 23, 2013
Last verified: October 2013

December 19, 2012
October 23, 2013
December 2013
December 2013   (final data collection date for primary outcome measure)
Heart rate of patient before CT coronary [ Time Frame: 1 January 2013 to 31 december 2013 ] [ Designated as safety issue: Yes ]
Same as current
Complete list of historical versions of study NCT01755663 on ClinicalTrials.gov Archive Site
safety and side effect of Metoprolol and Ivabradine [ Time Frame: 1 january 2013 to 31 december 2013 ] [ Designated as safety issue: Yes ]
Same as current
Image quality [ Time Frame: 1 january 2013 to 31 december 2013 ] [ Designated as safety issue: Yes ]
Same as current
 
Comparison of Efficacy of Ivabradine Versus Metoprolol
Comparison of Efficacy and Safety of Ivabradine Versus Metoprolol for Controlling Heart Rate Prior to 640-Slice Computed Tomographic Angiography in Elective Patients

Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.

Not Provided
Interventional
Phase 4
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver)
Primary Purpose: Diagnostic
Coronary Artery Disease
Drug: Ivabradine and Metoprolol
  • Experimental: Ivabradine
    Patients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol
    Intervention: Drug: Ivabradine and Metoprolol
  • Active Comparator: metoprolol
    Metoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine
    Intervention: Drug: Ivabradine and Metoprolol
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
60
December 2013
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital
  • Resting heart rate > 70 BPM
  • age > 18 years and informed consent

Exclusion Criteria:

  • Heart rate > 100 BPM
  • BP <100/60 mmHg
  • recent congestive heart failure in 1 mo.
  • SA node, AV node disease and AF
  • on permanent pacemaker
  • CrCL < 15ml/min. , AST or ALT > 3x UNL
  • on HR reducing drug such as diltiazem, verapamil, digitalis
  • contraindication for ivabradine or metoprolol
Both
18 Years to 80 Years
No
Contact: Purich Surunchupakorn, M.D. 081-988-7390 winnermd57@gmail.com
Thailand
 
NCT01755663
Pharmongkutklao
Yes
Col. Suthee Panichkul, Phramongkutklao College of Medicine and Hospital
Col. Suthee Panichkul
Phramongkutklao College of Medicine and Hospital
Principal Investigator: Purich - Surunchupakorn, M.D. Phramongkutklao College of Medicine and Hospital
Phramongkutklao College of Medicine and Hospital
October 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP