Comparison of Ultrafast Echo With Echotracking

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by French Cardiology Society
Sponsor:
Information provided by (Responsible Party):
French Cardiology Society
ClinicalTrials.gov Identifier:
NCT01743352
First received: December 4, 2012
Last updated: March 25, 2014
Last verified: March 2014

December 4, 2012
March 25, 2014
March 2013
March 2015   (final data collection date for primary outcome measure)
Local common carotid artery pulse wave velocity [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01743352 on ClinicalTrials.gov Archive Site
Common carotid artery Young's modulus (Stiffness of wall material) [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Comparison of Ultrafast Echo With Echotracking
Protocole ULTRAFAST - ECHOTRACKING : Remodelage pariétal et rigidité artérielle Chez l'Hypertendu : Nouvelle étude de Leur Relation Utilisant l'élastographie Par Ultrafast-écho et la séparation Intima/média Par écho-tracking

The aim is to compare a new technique for assessing mechanical properties of large arteries: the Ultrafast echo with the reference technique, the echotracking. This will be done by studying in parallel hypertensive patients and controls with both techniques and this will revisit old concepts of increased stiffness in hypertensive arteries.

Ultrafast ECHO is a new non invasive method for assessing stiffness of living tissues. It takes advantage of very fast imaging technologies (up to 20 000 images/sec) to measure the diffusion of pressure waves in the tissues. This pressure wave can be either natural (blood pressure), or generated by an very short ultrasonic impulsion at a given place. By using both modes, it is possible to have a precise cartography of tissue mechanical properties. This technique is applied to solid tissues such as breast or liver, but not yet currently to hollow tissues such as arteries. The aim of the present study is to compare the values of stiffness obtained with Ultrafast ECHO with the reference non invasive technique, the Echotracking, which measures stiffness by assessing the deformation of arteries in response to changes in blood pressure. On the physiological part, we will revisit old concepts of increased stiffness of hypertensive's arteries. Indeed, hypertension is associated with increased stiffness due to recruitement of collagen fibers, but also to chronic remodelling. We have shown before that this remodelling conducts to accumulation of arterial tissue of lesser intrinsic stiffness. The latter finding was done through models based on echotracking measurements. It will be interesting to see whether it holds true when stiffness is directly measured.

Sixty subjects (30 normotensive and30 hypertensives) will be included and studied once. Measurement will be performed in random order 3 time on the common carotid artery on both sides. Aortic stiffness will be measured by pulse wave velocity

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Patients presenting Essential untreated hypertension Healthy Volunteers

  • Essential Untreated Hypertension
  • Healthy Volunteers
Not Provided
  • Hypertension patients
    Local common carotid artery pulse wave velocity is compared in patients with hypertension and healthy volunteers.
  • Healthy Volunteers
    Local common carotid artery pulse wave velocity is compared in hypertension patients and healthy volunteers
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
60
April 2015
March 2015   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • hypertension,
  • essential (WHO workup),
  • untreated (> 28 days of treatment interruption, < 6 months of treatment) on insufficiently equilibrated (BP > 140 and/or 90 mmHg)

Exclusion Criteria:

  • Any concomitant severe disease compromising patient's participation or compliance
Both
25 Years to 70 Years
Yes
Contact: Stéphane Laurent, MD, PhD (33) 1 56 09 39 91 stephane.laurent@egp.aphp.fr
Contact: Pierre Boutouyrie, MD, PhD (33) 1 56 09 39 66 pierre.boutouyrie@egp.aphp.fr
France
 
NCT01743352
2012-01, ID - RCB 2012-A01255-38
No
French Cardiology Society
French Cardiology Society
Not Provided
Principal Investigator: Stéphane Laurent, MD, PhD Pharmacology Department - Hopital Européen Georges Pompidou - Paris
French Cardiology Society
March 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP