Effectiveness of Mirror Therapy in Stroke Patients With Unilateral Neglect - A Randomized Controlled Trial (MUST)

This study is currently recruiting participants.
Verified November 2012 by Christian Medical College and Hospital, Ludhiana, India
Sponsor:
Information provided by (Responsible Party):
jeyarajpandian, Christian Medical College and Hospital, Ludhiana, India
ClinicalTrials.gov Identifier:
NCT01735877
First received: November 26, 2012
Last updated: December 6, 2013
Last verified: November 2012

November 26, 2012
December 6, 2013
April 2010
December 2013   (final data collection date for primary outcome measure)
Unilateral neglect assessment tests [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Brunnstrom's stage of recovery Star cancellation test score Line bisection test score Catherine Bergego scale score
Same as current
Complete list of historical versions of study NCT01735877 on ClinicalTrials.gov Archive Site
Functional independence measure [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Functional independence measure
Same as current
Not Provided
Not Provided
 
Effectiveness of Mirror Therapy in Stroke Patients With Unilateral Neglect - A Randomized Controlled Trial
Effectiveness of Mirror Therapy in Stroke Patients With Unilateral Neglect - A Randomized Controlled Trial

Hemi spatial neglect, or the tendency to ignore stimuli originating in a portion of the environment contra lateral to a cerebral lesion, can be a major source of functional handicap after stroke. The currently available treatments for unilateral neglect are scanning training, visual cuing approaches, limb activation strategies, visual imagery, tactile stimulation, prisms and sustained attention training.Mirror therapy improves the hand function in sub-acute stroke.

Hypothesis: Mirror therapy will be effective in the management of stroke patients with unilateral neglect as compared to limb activation technique.

About 30 - 50% of stroke patients are left with considerable residual deficits. The post stroke disabilities are due to loss of locomotion and activities of daily living, cognition and communication skills.Hemispatial neglect has been reported in association with damage to several different cerebral structures in a large-scale distributed neurocognitive network.Mirror therapy improves the hand function in sub-acute stroke. It also helps in the recovery of neglect in stroke patients. But little consensus exists as to whether one treatment is more efficacious than others and many studies fail to document duration of treatment effects or generalization to daily activities. The aim of our study is to evaluate the effectiveness of limb activation with MT and limb activation strategy alone in the management of stroke patients with unilateral neglect and to make the patient functional in activities of daily living.

Interventional
Phase 3
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Hemispatial Neglect
  • Other: Mirror therapy
    During the mirror practices, patients were seated close to a table on which a mirror (35×35cm) was placed vertically. The practice consisted of non paretic-side wrist and finger flexion and extension movements while patients looked into the mirror, watching the image of their noninvolved hand, thus seeing the reflection of the hand movement projected over the involved hand. Patients could see only the noninvolved hand in the mirror; otherwise, the noninvolved hand was hidden from sight. During the session patients were asked to try to do the same movements with the paretic hand while they were moving the non paretic hand.
  • Other: Control group
    The control group performed the same exercises for the same duration but used the nonreflecting side of the mirror in such a way that the paretic hand was hidden from sight. The same therapist delivered the control therapy to the patients. Both the treatment and the control group received limb activation.
  • Experimental: Mirror therapy
    All eligible patients will be randomly allocated into 2 groups. Group 1 will be given Mirror therapy
    Interventions:
    • Other: Mirror therapy
    • Other: Control group
  • Sham Comparator: Control group
    Group 2 will be given sham mirror therapy
    Intervention: Other: Control group
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
96
January 2014
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria: 1.All stroke patients with parietal lobe and thalamic lesions 2. Stroke duration: After 48 hours 3. Patients willing to participate in the study 4. MRI/ CT scan showing parietal lobe and thalamic lesion

Exclusion Criteria:

  1. Stroke duration more than 1 yr
  2. Patients with cognitive deficits
  3. Uncooperative patients
Both
18 Years and older
No
Contact: Dheeraj KV, MPT 919988048831 dheeraj_25@yahoo.com
Contact: Rajni Arora, MPT 7814406168 drrajniarora@gmail.com
India
 
NCT01735877
MT2012
No
jeyarajpandian, Christian Medical College and Hospital, Ludhiana, India
Christian Medical College and Hospital, Ludhiana, India
Not Provided
Principal Investigator: Jeyaraj Pandian, DM BFUHS
Christian Medical College and Hospital, Ludhiana, India
November 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP