Carbohydrate Use During and Following Exercise (CHO-use)

This study is not yet open for participant recruitment.
Verified October 2012 by Maastricht University Medical Center
Sponsor:
Information provided by (Responsible Party):
Maastricht University Medical Center
ClinicalTrials.gov Identifier:
NCT01709617
First received: October 11, 2012
Last updated: October 16, 2012
Last verified: October 2012

October 11, 2012
October 16, 2012
November 2012
September 2013   (final data collection date for primary outcome measure)
  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 0 min during trials 1-3 ] [ Designated as safety issue: No ]
    Carbohydrate oxidation as measured by breath samples
  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 0 min during trials 1-3 ] [ Designated as safety issue: No ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
  • Glycogen utilization (Part B) [ Time Frame: immediately post exercise (~90min), during trials 4-6 ] [ Designated as safety issue: No ]

    Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

    Part B; trials 4-6.

  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 30 min during trials 1-3 ] [ Designated as safety issue: No ]
    Carbohydrate oxidation as measured by breath samples
  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 60 min during trials 1-3 ] [ Designated as safety issue: No ]
    Carbohydrate oxidation as measured by breath samples
  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 90 min during trials 1-3 ] [ Designated as safety issue: No ]
    Carbohydrate oxidation as measured by breath samples
  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 120 min during trials 1-3 ] [ Designated as safety issue: No ]
    Carbohydrate oxidation as measured by breath samples
  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 150 min during trials 1-3 ] [ Designated as safety issue: No ]
    Carbohydrate oxidation as measured by breath samples
  • Exogenous carbohydrate oxidation rate (Part A) [ Time Frame: 180 min during trials 1-3 ] [ Designated as safety issue: No ]
    Carbohydrate oxidation as measured by breath samples
  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 30 min during trials 1-3 ] [ Designated as safety issue: No ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 60 min during trials 1-3 ] [ Designated as safety issue: No ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 90 min during trials 1-3 ] [ Designated as safety issue: No ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 120 min during trials 1-3 ] [ Designated as safety issue: No ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 150 min during trials 1-3 ] [ Designated as safety issue: No ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
  • Endogenous carbohydrate oxidation (Part A) [ Time Frame: 180 min during trials 1-3 ] [ Designated as safety issue: No ]
    endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
  • Glycogen utilization (Part B) [ Time Frame: 3 h post exercise during trials 4-6 ] [ Designated as safety issue: No ]

    Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

    Part B; trials 4-6.

  • Glycogen utilization (Part B) [ Time Frame: 6 h post exercise during trials 4-6 ] [ Designated as safety issue: No ]

    Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.

    Part B; trials 4-6.

Same as current
Complete list of historical versions of study NCT01709617 on ClinicalTrials.gov Archive Site
  • Indirect calorimetry (Part A) [ Time Frame: every 30 min up to 180 min during trials 1-3 ] [ Designated as safety issue: No ]
    Measurements of VO2, VCO2 and RER through indirect calorimetry measured every 30 minutes during trials 1-3
  • Plasma glucose [ Time Frame: every 30 min up to 180 min during trials 1-6 ] [ Designated as safety issue: No ]
    Plasma glucose measurements
  • Plasma insulin [ Time Frame: every 30 minutes up to 180 min during trials 1-6 ] [ Designated as safety issue: No ]
    plasma insulin measurements
Same as current
Not Provided
Not Provided
 
Carbohydrate Use During and Following Exercise
Sucrose as a Preferred Carbohydrate in Sports Nutrition

Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise
Dietary Supplement: Carbohydrate ingestion
Various types of carbohydrate ingested during and following exercise
  • Experimental: Glucose-glucose
    Glucose ingestion
    Intervention: Dietary Supplement: Carbohydrate ingestion
  • Active Comparator: Glucose-Fructose
    glucose-fructose ingestion
    Intervention: Dietary Supplement: Carbohydrate ingestion
  • Active Comparator: disaccharide
    Disaccharide ingestion
    Intervention: Dietary Supplement: Carbohydrate ingestion
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
17
January 2014
September 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy
  • Male
  • 18 - 40 years of age
  • Endurance trained cyclist/triathlete
  • VO2 max ≥ 50 ml/kg/min
  • BMI < 25 kg/m2

Exclusion Criteria:

  • Use of medication
  • Smoking
Male
18 Years to 40 Years
Yes
Contact: Naomi Cermak, Ph.D. 31433881393 naomi.cermak@maastrichtuniversity.nl
Netherlands
 
NCT01709617
12-3-048
No
Maastricht University Medical Center
Maastricht University Medical Center
Not Provided
Principal Investigator: Luc van Loon, Ph.D. Maastricht University
Maastricht University Medical Center
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP