The MURDOCK Study Registry and Biorepository Horizon 1.5

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2014 by Duke University
Sponsor:
Information provided by (Responsible Party):
Duke University
ClinicalTrials.gov Identifier:
NCT01708408
First received: October 15, 2012
Last updated: September 15, 2014
Last verified: September 2014

October 15, 2012
September 15, 2014
February 2009
December 2018   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT01708408 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
The MURDOCK Study Registry and Biorepository Horizon 1.5
Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis The MURDOCK Study Registry and Biorepository Horizon 1.5

The MURDOCK Study Community Registry and Biorepository (Horizon 1.5) aims to create a large-scale community registry and biorepository that can be used as a vehicle for future health services, epidemiologic, clinical trials and other omics-related research.

The MURDOCK Study Community Registry and Biorepository's activities include enrolling approximately 50,000 participants who live in Cabarrus County and/or Kannapolis, North Carolina. Participants must consent to (1) use of the data provided by the participant through completion of the Participant Registry Questionnaire for epidemiologic population characterization, (2) annual contact to update their MURDOCK Horizon 1.5 database record, (3) release of their medical information, including but not limited to demographic information, problem lists, medications, social and family history, and results of laboratory and other testing modalities from pre-existing paper or electronic health records or electronic health records that may become available in the future, (4) provision of a blood and urine sample, and (5) contact up to four times/year to request participation in additional research studies.

Observational
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Blood, 50 mL (whole blood, plasma, serum, buffy coat, PAXgene); Urine, 36 mL

Non-Probability Sample

The Community Registry and Biorepository is designed to create a community registry and biorepository populated by approximately 50,000 residents of Cabarrus County and/or the city of Kannapolis in North Carolina.

  • Chronic Disease
  • Healthy Volunteers
Genetic: Biomarker studies
community
Intervention: Genetic: Biomarker studies
Tenenbaum JD, Christian V, Cornish MA, Dolor RJ, Dunham AA, Ginsburg GS, Kraus VB, McHutchison JG, Nahm ML, Newby LK, Svetkey LP, Udayakumar K, Califf RM. The MURDOCK Study: a long-term initiative for disease reclassification through advanced biomarker discovery and integration with electronic health records. Am J Transl Res. 2012;4(3):291-301. Epub 2012 Jul 23.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
50000
December 2018
December 2018   (final data collection date for primary outcome measure)

Inclusion Criteria:

  1. A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) for 6 or more months of the year
  2. At least 18 years of age
  3. Able to understand and give written informed consent, or have a legal guardian or caregiver present to give informed consent by proxy (assent from a participant between ages 12-18 will be obtained when their parent or legal guardian consents on their behalf).
  4. Willing and able to participate in all 5 components of the registry and biorepository as described above in Section III

Exclusion Criteria:

1. There are no exclusions to participation if all inclusion criteria have been met.

Both
18 Years and older
Yes
Contact: Leah Bouk 704-250-5856 leah.bouk@duke.edu
Contact: Perla Nunes 704-250-5858 perla.nunes@duke.edu
United States
 
NCT01708408
Pro00011196
Yes
Duke University
Duke University
Not Provided
Principal Investigator: Robert M Califf, MD Duke University
Duke University
September 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP