Polymorphids an mRNA Expression in Obese Genes

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Anders Thorell, Karolinska Institutet
ClinicalTrials.gov Identifier:
NCT01708083
First received: October 9, 2012
Last updated: August 21, 2013
Last verified: August 2013

October 9, 2012
August 21, 2013
January 2010
February 2013   (final data collection date for primary outcome measure)
  • Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity [ Time Frame: approximatly 30 minutes after start of operation ] [ Designated as safety issue: No ]
    fat biopsy taken from abdomen, omenta and thigh at surgery
  • Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2 [ Time Frame: approximatly 30 minutes after start of operation ] [ Designated as safety issue: No ]
    fat biopsy; abdomen, omenta and thigh taken at surgery
  • Differences in polymorphies and/or mRNA expression in genes, significant for developing obesity and typ 2 diabetes, between patients with normal weight and obesity [ Time Frame: approximatly 30 minutes after start of operation ] [ Designated as safety issue: No ]
    fat biosys taken from abdomen, oment and thigh at surgery
  • Difference in polymorphies and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity whith or without diabetes typ 2 [ Time Frame: approximatly 30 minutes after start of operation ] [ Designated as safety issue: No ]
    fat biosys; abdomen, oment and thigh taken at surgery
Complete list of historical versions of study NCT01708083 on ClinicalTrials.gov Archive Site
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Polymorphids an mRNA Expression in Obese Genes
Polymorphids and mRNA Expression in Genes, Significant for Developing Obesity and Typ II Diabetes in Different Types/Localisations of Fat Tissue

Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).

Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .

Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

biopsys; Fat from oment, thigh and abdomen

Non-Probability Sample

Tree groups; group I: diabetes type II with BMI>35 Group II: no diabetes BMI>35 Group III: no diabetes BMI 18-27

  • Polymorphism
  • mRNA Expression
Not Provided
  • Type 2 Diabetes and BMI>35
    Patients with type 2 diabetes and body mass index 35 or more.
  • BMI>35
    Patients undergoing surgery, gastric bypass or cholecystectomy, without diabetes type 2 and body mass index 35 or more
  • BMI 18-27
    Patients undergoing surgery, cholecystectomy or reflux, without type 2 diabetes and body mass index between 18-27
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
50
February 2013
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • age 18 years or older
  • laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery)
  • Normal weight without type 2 diabetes BMI 18-25
  • Obese without type 2 diabetes BMI>35
  • Obese with type 2 diabetes BMI>35

Exclusion Criteria:

  • under 18 years
  • open surgery
  • pregnancy
  • BMI >27-<35
Both
18 Years to 80 Years
No
Contact information is only displayed when the study is recruiting subjects
Sweden
 
NCT01708083
2009/1629-31/3
No
Anders Thorell, Karolinska Institutet
Karolinska Institutet
Not Provided
Principal Investigator: Anders Thorell, Ass. prof. Karolinska Institutet
Karolinska Institutet
August 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP