Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified September 2012 by Xijing Hospital
Sponsor:
Information provided by (Responsible Party):
Xijing Hospital
ClinicalTrials.gov Identifier:
NCT01698853
First received: September 25, 2012
Last updated: September 29, 2012
Last verified: September 2012

September 25, 2012
September 29, 2012
October 2012
March 2013   (final data collection date for primary outcome measure)
The difference between peripheral arterial oxygenation and aortic root blood oxygenation [ Time Frame: patients will be followed up during the cardiopulmonary bypass. Blood samples will be collected at 3 timepoints which is specified in the DESCRIPTION ] [ Designated as safety issue: Yes ]
The three time points for blood sample collection are:1.right before clamping the aorta; 2.Three minutes after **** without ventilation;3.5 min after re-initiate mechanical ventilation.
Same as current
Complete list of historical versions of study NCT01698853 on ClinicalTrials.gov Archive Site
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Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
The Difference Between Central and Peripheral Arterial Blood Oxygen Saturation in Patients Undergoing Cardiac Surgery With Different Cardiopulmonary Bypass Strategy

Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.

Arterial blood gas analysis can help to detect hypoperfusion or hypoxia during retrograde perfusion. However,whether the arterial oxygenation status from different parts of the body are the same in the condition of retrograde perfusion have not been studied.

The present study is aimed to determine if there is difference in the arterial oxygenation between peripheral arterial and aortic root during the period of retrograde perfusion.In addition, the impact of artificial ventilation on the difference of arterial oxygenation will also be investigated.

All patients included will be assigned into two different groups according to the surgical approach,one group is named "NP" with normal perfusion,and the other is named "RP" with retrograde perfusion.

For all the patients,we will obtain 0.5ml blood from both peripheral arterial and aortic root for blood gas analysis at some specific time points.

We will focus on the differences of arterial oxygenation between peripheral arterial and aortic root at each group.At the same time,we will analyse the impact of artificial ventilation on it.

Observational
Time Perspective: Prospective
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Non-Probability Sample

patient undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass

  • Bypass Complications
  • Disorder of Blood Gas
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
60
May 2013
March 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • age > 18 years old
  • undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

  • without informed consent
  • pregnancy
Both
18 Years and older
No
Contact: Min Chen, M.D. 86-13991221157 chenminh@yahoo.com.cn
Contact: Jing Zhao, M.D. 86-13892810471 zhaojing939699@126.com
China
 
NCT01698853
192837
No
Xijing Hospital
Xijing Hospital
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Study Chair: Hailong Dong, Doctor department director
Xijing Hospital
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP