Quantification and Description of the Increase in Serum Troponin Following Acute Coronary Syndrome (QUANTUM)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2012 by Université de Sherbrooke.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Université de Sherbrooke
ClinicalTrials.gov Identifier:
NCT01698021
First received: September 28, 2012
Last updated: June 25, 2013
Last verified: September 2012

September 28, 2012
June 25, 2013
June 2013
November 2013   (final data collection date for primary outcome measure)
Evaluation of troponins kinetic in acute coronary syndromes. [ Time Frame: 72 hours ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT01698021 on ClinicalTrials.gov Archive Site
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Quantification and Description of the Increase in Serum Troponin Following Acute Coronary Syndrome
Quantification and Description of the Increase in Serum Troponin Following Acute Coronary Syndrome

The new assay of troponins T (highly sensitive troponins) detects concentrations much lower than before. Few data are currently available on their kinetics during acute coronary syndrome, especially in regard to the correlation with CK MB. The aim of the present study is to describe the kinetic of highly sensitive troponins in acute coronary syndrome, to correlate it with the concentration of CK MB, and possibly to evaluate their prognostic value with respect to infarct size .

Patients who meet the inclusion criteria will have a highly sensitive troponins and CKMB assays q 8hr for the first day, and q 12h for the next 2 days. If clinically not indicated, the blood sample can be cancelled at any time, as in the case of a patient with an initial suspicion of acute coronary syndrome in which the final diagnosis is something else. Only patients with a definitive myocardial infarction will be analyzed.

Subgroup analyses includes ST-elevation MI, Non ST-elevation MI, revascularization vs no revascularization, procedural myocardial infarction.

Another analysis conducted is the correlation between the values ​​of troponin and infarct size by echocardiography (in patients who have an echocardiography 2-7 days post AND 2-6 months post myocardial infarction)

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

All consecutive patients presenting to the emergency department or being hospitalized for any reason in which we suspect an acute coronary syndrome.

  • Acute Coronary Syndrome
  • Myocardial Infarction
  • Unstable Angina
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
500
November 2013
November 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • >= 18 years-old
  • Clinical suspicion of an acute coronary syndrome; (will be analyzed only patients with aposteriori definitive diagnosis of unstable angina or myocardial infarction)

Exclusion Criteria:

  • none
Both
18 Years and older
No
Contact: Paul Farand, MD MSc (819) 346-1110 ext 9093 pagette paul.farand@usherbrooke.ca
Contact: Francis Bonenfant, resident (819) 346-1110 ext 4987 pagette francis.bonenfant@usherbrooke.ca
Canada
 
NCT01698021
Projet 12-081
No
Université de Sherbrooke
Université de Sherbrooke
Not Provided
Principal Investigator: Paul Farand, Md MSc Centre Hospitalier Universitaire de Sherbrooke
Université de Sherbrooke
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP