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Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Javier Gonzalez, Northumbria University
ClinicalTrials.gov Identifier:
NCT01682343
First received: September 6, 2012
Last updated: September 10, 2012
Last verified: September 2012
History of Changes

September 6, 2012
September 10, 2012
May 2012
August 2012   (final data collection date for primary outcome measure)
Subjective appetite ratings [ Time Frame: 3 hour ] [ Designated as safety issue: No ]
Subjective ratings of appetite assessed by visual analogue scales.
Same as current
Complete list of historical versions of study NCT01682343 on ClinicalTrials.gov Archive Site
  • Serum insulin concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]
    2 hour area under the curve for serum insulin following breakfast consumption
  • Plasma glucose-dependent insulinotropic peptide concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]
    2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption
  • Plasma glucagon-like peptide-1 concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]
    2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption
  • Serum insulin concentration [ Time Frame: 2 h ] [ Designated as safety issue: No ]
    2 h area under the curve for serum insulin following breakfast consumption
  • Plasma glucose-dependent insulinotropic peptide concentration [ Time Frame: 2 h ] [ Designated as safety issue: No ]
    2 h area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption
  • Plasma glucagon-like peptide-1 concentration [ Time Frame: 2 h ] [ Designated as safety issue: No ]
    2 h area under the curve for plasma glucagon-like peptide-1 following breakfast consumption
Total fat oxidised during 60 min of exercise (g) [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Assessed by indirect calorimetry
Total fat oxidised during 60 min of exercise (g) [ Time Frame: 1 h ] [ Designated as safety issue: No ]
Assessed by indirect calorimetry
 
Effect of High-calcium Intake on Appetite, Insulinemia and Incretins
Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.

Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Nutritional and Metabolic Diseases
Dietary Supplement: Calcium
Milk-calcium supplement
  • Placebo Comparator: Placebo
    Breakfast consisting of milk-based porridge with a normal calcium content.
  • Experimental: High-Calcium
    As control, but with a high-calcium content.
    Intervention: Dietary Supplement: Calcium
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10
August 2012
August 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • recreationally active
  • male

Exclusion Criteria:

  • food intolerances/allergies
Male
Not Provided
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT01682343
32AN2
No
Javier Gonzalez, Northumbria University
Northumbria University
Not Provided
Principal Investigator: Javier T Gonzalez, MRes Northumbria University
Northumbria University
September 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP