Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Cindy Anderson, USDA Grand Forks Human Nutrition Research Center
ClinicalTrials.gov Identifier:
NCT01682304
First received: September 5, 2012
Last updated: September 22, 2013
Last verified: September 2013

September 5, 2012
September 22, 2013
May 2012
March 2014   (final data collection date for primary outcome measure)
DNA methylation pattern [ Time Frame: age 30-65 ] [ Designated as safety issue: No ]
Determine DNA methylatiion patterns in women with hypertension who have/have not had a prior diagnosis of preeclampsia
Not Provided
Complete list of historical versions of study NCT01682304 on ClinicalTrials.gov Archive Site
Vascular function [ Time Frame: aged 30-65 ] [ Designated as safety issue: No ]
Determine differences in vascular function among women aged 30-65, diagnosed with hypertension and who have/have not had a prior diagnosis of preeclampsia
Not Provided
Not Provided
Not Provided
 
Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension
Observational Study of Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension

Preliminary data from the investigator's lab identified novel patterns of differential DNA methylation in genes regulating cardiovascular and metabolic function in blood from women during the first trimester of pregnancy who were destined to develop preeclampsia (PE) in the third trimester. Further, common patterns of differential DNA methylation were found in the common genes from placental tissue at time of birth in the same women after diagnosis with PE, suggesting that the epigenomic patterns that predict pregnancy-induced hypertension may also underlie the development of chronic hypertension years after.

It is unknown whether aberrant DNA methylation in pregnancy-induced hypertension is the mechanism by which chronic hypertension develops in these women remote from pregnancy nor is it known if hypertension remote from PE is as responsive to therapeutic treatment of hypertension compared to women who develop hypertension without history of PE. The investigators plan to objectively test the central hypothesis and attain the objective of this project

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Sputum and peripheral blood will be collected for DNA extraction and epigenetic analyses.

Probability Sample

Females diagnosed with chronic hypertension with a prior pregnancy

  • Preeclampsia
  • Hypertension
  • Pregnancy Induced Hypertension
Not Provided
History of Preeclampsia
Chronic hypertension with history of preeclampsia Chronic hypertension without history of preeclampsia
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
80
Not Provided
March 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Female gender
  • history of prior pregnancy
  • diagnosis of chronic hypertension
  • current treatment of chronic hypertension
  • age 30 - 50 years old

Exclusion Criteria:

  • presence of comorbid conditions that influence cardiovascular health (SLE, congenital cardiac anomalies
Female
30 Years to 65 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01682304
GFHNRC611
No
Cindy Anderson, USDA Grand Forks Human Nutrition Research Center
USDA Grand Forks Human Nutrition Research Center
Not Provided
Not Provided
USDA Grand Forks Human Nutrition Research Center
September 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP