Preference of Genetic Polymorphism and Pharmacokinetics

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
To Kin Wang, Chinese University of Hong Kong
ClinicalTrials.gov Identifier:
NCT01658371
First received: February 27, 2012
Last updated: August 2, 2012
Last verified: August 2012

February 27, 2012
August 2, 2012
May 2008
December 2009   (final data collection date for primary outcome measure)
pharmacokinetics [ Time Frame: 24 hour ] [ Designated as safety issue: No ]
This includes plasma concentration of drugs in relation to time, in different genotypes
Same as current
Complete list of historical versions of study NCT01658371 on ClinicalTrials.gov Archive Site
genotypes frequency [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Preference of Genetic Polymorphism and Pharmacokinetics
Preference of CYP450 2B6 516 G>T Polymorphism and Pharmacokinetics of Plasma Efavirenz in A Group of HIV Infected Southern Chinese

Genetic polymorphism affects plasma concentration of antiretroviral therapy in HIV patients. The investigators investigate the prevalence of genetic polymorphism affecting efavirenz metabolism and the corresponding pharmacokinetics of different genotypes.

Eligible patients are invited to donate blood samples for pharmacokinetic study and genotype analysis

Observational
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

Southern Chinese HIV patients

HIV
Not Provided
efavirenz
HIV patients on efavirenz
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
100
June 2010
December 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Southern Chinese HIV patients on efavirenz

Exclusion Criteria:

  • Refuse to sign consent, HIV patients not on efavirenz
Both
Not Provided
No
Contact information is only displayed when the study is recruiting subjects
China
 
NCT01658371
CRE-2008.180
No
To Kin Wang, Chinese University of Hong Kong
Chinese University of Hong Kong
Not Provided
Principal Investigator: S S Lee, Professor Chinese University of Hong Kong
Chinese University of Hong Kong
August 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP