Neuroimaging Studies of the Treatment of Bipolar Depression With Citalopram

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Darin Dougherty, Massachusetts General Hospital
ClinicalTrials.gov Identifier:
NCT01639482
First received: July 10, 2012
Last updated: September 15, 2014
Last verified: September 2014

July 10, 2012
September 15, 2014
April 2010
December 2013   (final data collection date for primary outcome measure)
rCMRglu [ Time Frame: pre and post-treatment ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT01639482 on ClinicalTrials.gov Archive Site
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Neuroimaging Studies of the Treatment of Bipolar Depression With Citalopram
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Regional metabolic changes associated with response to 6 weeks of citalopram treatment, using 18-Fluorodeoxyglucose Positron Emission Tomography imaging, will be characterized (FDG PET). The following hypothesis will be tested: Antidepressant response or remission in depressed BPD patients will be associated with changes in cortical (prefrontal, parietal, premotor) and paralimbic (hippocampus, anterior cingulate, subgenual cingulate, posterior cingulate, and anterior insula) regions, consistent with SRI antidepressant response in unipolar depressed patients.

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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Probability Sample

Patients with Bipolar Depression

Bipolar Depression
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  • Citalopram
  • Placebo
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
60
December 2013
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Current age 18-64 years; DSM-IV diagnosis of BPD, type-I, or type-II; Enrolled in the Citalopram Study at Tufts Medical Center

Exclusion Criteria:

  • Current pregnancy, or inability to utilize contraception, The presence of any metallic implants, History of claustrophobia
Both
18 Years to 64 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01639482
2009P002712
No
Darin Dougherty, Massachusetts General Hospital
Massachusetts General Hospital
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Massachusetts General Hospital
September 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP