Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study (TNT-HIV)

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2012 by Thai Red Cross AIDS Research Centre
Sponsor:
Collaborators:
HIV Netherlands Australia Thailand Research Collaboration
Bamrasnaradura Infectious Diseases Institute
Chulalongkorn University
Queen Savang Vadhana Memorial Hospital, Thailand
Information provided by (Responsible Party):
Thai Red Cross AIDS Research Centre
ClinicalTrials.gov Identifier:
NCT01634477
First received: July 2, 2012
Last updated: July 5, 2012
Last verified: July 2012

July 2, 2012
July 5, 2012
January 2010
October 2016   (final data collection date for primary outcome measure)
  • morbidity [ Time Frame: 60 months ] [ Designated as safety issue: Yes ]
    development of other diseases
  • HIV related illness [ Time Frame: 60 months ] [ Designated as safety issue: Yes ]
    development of opportunistic infection such as Non-Hodkin's lymphoma, Kaposi's sarcoma
  • Non HIV-related illness [ Time Frame: 60 months ] [ Designated as safety issue: Yes ]
    development of Dyslipidemia, Hypertension, DM, CVD , Cancer, osteopenia, osteoporosis, Renal disease, liver disease
  • mortality [ Time Frame: 60 months ] [ Designated as safety issue: No ]
    death
  • CVD [ Time Frame: 60 months ] [ Designated as safety issue: Yes ]
    development of CVD
Same as current
Complete list of historical versions of study NCT01634477 on ClinicalTrials.gov Archive Site
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Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study
Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study
  1. To describe the morbidity and clinical characteristics among HIV-infected patients and HIV-uninfected patients.
  2. To identify the risk factors for the complication or morbidity among HIV-infected patients and HIV-uninfected patients.
  3. To describe the mortality among HIV-infected patients and HIV-uninfected patients.
  4. To identify the risk factors for the cause of death among HIV-infected and HIV-uninfected patients.

The information obtained from this study would be very important in planning future holistic care of HIV-infected patients in our institutes as well as in national policy. Results from the study could be used to develop proper long-term management guidelines for people living with HIV (PLHIV) in Thailand targeted at preventable conditions such as metabolic diseases and certain cancers.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

Thai HIV-infected patients with and without ART, and HIV negative patients from the Thai Red Cross AIDS Research Centre and Queen Savang Memorial Hospital Institute during January 2010 - December 2014

  • HIV Infection
  • Healthy
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  • HIV-infected patients group
    HIV positive
  • HIV-uninfected patients group
    HIV negative
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
816
October 2016
October 2016   (final data collection date for primary outcome measure)

Inclusion Criteria:

HIV-infected patients group

  • HIV positive
  • 30 years of age or older, both male and female
  • Thai nationality
  • Written research informed consent

HIV-uninfected patients group

  • HIV un-infected
  • 30 years of age or older, both male and female
  • Thai nationality
  • Written research informed consent

Exclusion Criteria:

HIV-infected patients group

  • Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment
  • Fasting blood sugar > 126 mg/dl or on the treatment
  • Proteinuria
  • Creatinine > 1.5 mg/dl
  • Recent hospitalization
  • Patient who are having mental disease HIV-uninfected patients group
  • Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment
  • Fasting blood sugar > 126 mg/dl or on the treatment
  • Proteinuria
  • Creatinine > 1.5 mg/dl
  • Recent hospitalization
  • Patient who are having mental disease
Both
30 Years and older
Yes
Contact: Jureeporn Jantarapakde +662-253-0997 jureepornj@trcarc.org
Contact: Nittaya Phanuphak +662-253-0996 nittaya.p@trcarc.org
Thailand
 
NCT01634477
TNT-HIV 003
No
Thai Red Cross AIDS Research Centre
Thai Red Cross AIDS Research Centre
  • HIV Netherlands Australia Thailand Research Collaboration
  • Bamrasnaradura Infectious Diseases Institute
  • Chulalongkorn University
  • Queen Savang Vadhana Memorial Hospital, Thailand
Principal Investigator: Praphan Phanuphak, MD The Thai Red Cross AIDS Research Centre
Thai Red Cross AIDS Research Centre
July 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP