Levothyroxine for Children With Euthyroid Sick Syndrome

This study is currently recruiting participants.
Verified June 2012 by Sinaloa Pediatric Hospital
Sponsor:
Information provided by (Responsible Party):
Jesús Javier Martínez-García, Sinaloa Pediatric Hospital
ClinicalTrials.gov Identifier:
NCT01631305
First received: June 26, 2012
Last updated: June 27, 2012
Last verified: June 2012

June 26, 2012
June 27, 2012
January 2012
January 2013   (final data collection date for primary outcome measure)
All cause mortality [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 3 weeks ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01631305 on ClinicalTrials.gov Archive Site
  • Length of time in intensive care [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks ] [ Designated as safety issue: No ]
  • Ventilation days [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks ] [ Designated as safety issue: No ]
  • Use of vasopressors [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 3 weeks ] [ Designated as safety issue: No ]
  • Thyroid hormones levels [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 3 weeks ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Levothyroxine for Children With Euthyroid Sick Syndrome
Efficacy and Safety of Levothyroxine in Critical Children With Euthyroid Sick Syndrome in a Pediatric Intensive Care Unit.

The purpose of this study is to determine whether levothyroxine is effective and safe in the treatment of children with euthyroid sick syndrome, hospitalized in a pediatric intensive care unit.

Not Provided
Interventional
Phase 4
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Euthyroid Sick Syndrome
  • Drug: Levothyroxine
    3 mcg/kg/day
    Other Name: Brand: Eutirox.
  • Other: Calcium magnesia
    Placebo.
  • Experimental: Levothyroxine
    3 mcg/kg/day
    Intervention: Drug: Levothyroxine
  • Placebo Comparator: Control
    Calcium magnesia.
    Intervention: Other: Calcium magnesia
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
80
Not Provided
January 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • All children aged 1 month to 17 years.
  • Admitted to pediatric intensive care unit.
  • TSH and thyroid hormones below age specific levels.

Exclusion Criteria:

  • Known thyroid condition.
  • Brain death.
  • Gut conditions that contraindicate oral route.
  • Readmissions to intensive care unit.
Both
1 Month to 17 Years
No
Contact: Jesus J Martinez, MD +52 (667) 7139004 ext 274 jjmtz64@hotmail.com
Contact: Rossana Contreras, MD +52 (667) 7164686 anasor100@hotmail.com
Mexico
 
NCT01631305
HPS-01
Not Provided
Jesús Javier Martínez-García, Sinaloa Pediatric Hospital
Sinaloa Pediatric Hospital
Not Provided
Study Chair: Jesus J Martinez, MD Sinaloa Pediatric Hospital
Sinaloa Pediatric Hospital
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP