Study of Human Sensory Perception

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2013 by Swedish Medical Center
Sponsor:
Collaborator:
Weizmann Institute of Science
Information provided by (Responsible Party):
Swedish Medical Center
ClinicalTrials.gov Identifier:
NCT01613911
First received: June 5, 2012
Last updated: May 29, 2013
Last verified: May 2013

June 5, 2012
May 29, 2013
March 2012
March 2014   (final data collection date for primary outcome measure)
Reveal induced neuronal activity [ Time Frame: Approximately 3 hours over the course of 2-3 days during in-patient invasive electrophysiological monitoring. ] [ Designated as safety issue: No ]
In the preprocessing stage, potential electrical interference will be removed from the raw signal using a linear-phase notch FIR filter. Each electrode will be de-referenced by subtraction of the averaged signal of all the electrodes, thus discarding non-neuronal contributions. Time-frequency decompositions will be calculated for each electrode based on Fourier transform amplitude spectrum in a 160ms sliding window with average step size of 6ms. This process is done per trial and averaged across trials in order to reveal induced neuronal activity, which is not time-locked to the stimuli.
Reveal induced neuronal activity [ Time Frame: Approximately 3 hours over the course of 2-3 days during in-patient invasive electrophysiological monitoring. ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT01613911 on ClinicalTrials.gov Archive Site
Calculate evoked response potentials. [ Time Frame: Approximately 3 hours over the course of 2-3 days during in-patient invasive electrophysiological monitoring. ] [ Designated as safety issue: No ]
Evoked response potentials (ERPs) will be calculated by averaging the raw signal across the presentation of a specific stimulus for each patient, such as all samples of patients watching the movie clip.
Calculate evoked response potentials. [ Time Frame: Approximately 3 hours over the course of 2-3 days during in-patient invasive electrophysiological monitoring. ] [ Designated as safety issue: No ]
Not Provided
Not Provided
 
Study of Human Sensory Perception
A Combined fMRI and Electrophysiological Study of Human Sensory Perception

This study will help describe how the human brain works when a person sees something, hears something, learns something, or thinks about something by recording brain activity that occurs when the person does a series of computer tasks. This study will be offered to people who are in the hospital to be monitored for epilepsy by using electrodes placed in the brain. The study will record brain activity that occurs when a patient does a memory task, for example.

Patients who have elected to have invasive electrophysiological monitoring for epileptic activity are invited to participate in this study. While the electrodes are in place, patients are asked to view several scenarios on a laptop computer. During these scenarios, for example, patients are asked to click a mouse button if they see the same picture twice in a row or to remember a film clip of a scooter ride. Trigger points in the computer scenarios are recorded on a separate channel alongside the brain-wave activity to allow correlation between the brain activity and the task requested in the scenario. Using this technique, researchers can determine what areas of the brain were active during recognition or recall activities.

Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Not Provided
Not Provided
Non-Probability Sample

People between 10 and 65 years old diagnosed with epilepsy who will have invasive eletrophysioloigcal monitoring as part of a clinical evaluation for epilepsy treatment.

Epilepsy
Not Provided
Epileptics having invasive monitoring
People between 10 and 65 years of age with epilepsy and who are coming in to have invasive electrophysiological monitoring.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
24
March 2014
March 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Primary diagnosis of epilepsy
  • Between 10 and 65 years of age
  • Scheduled to undergo invasive electrophysiological monitoring as part of a clinical evaluation for epilepsy treatment

Exclusion Criteria:

  • None
Both
10 Years to 65 Years
No
Contact: Becky Wood 206-320-7115 becky.wood@swedish.org
Contact: Colleen Ottinger 206-320-3695 colleen.ottinger@swedish.org
United States
 
NCT01613911
5146S-11
No
Swedish Medical Center
Swedish Medical Center
Weizmann Institute of Science
Not Provided
Swedish Medical Center
May 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP