The Effect of LY2409021 on Blood Sugar Levels When Glucagon Levels Are Increased in Healthy Male Participants

• Total glucose released from the liver during a 3-hour glucagon infusion [ Time Frame: During a 3-hour glucagon infusion ] [ Designated as safety issue: No ]
• Maximum glucose release from the liver during a 3-hour glucagon infusion [ Time Frame: During a 3-hour glucagon infusion ] [ Designated as safety issue: No ]

This is a study to measure the effect that various doses of LY2409021 have on blood sugar levels and on the amount of glucose released by the liver, when glucagon is given to increase these. Each participant may receive up to 2 single doses of LY2409021 in 2 different study periods, with a minimum 13-day washout between dosing periods. This study is approximately 9 weeks long, not including screening. A screening appointment is required within 6 weeks prior to the start of the study.

• Drug: Placebo
  Administered orally, single dose
• Drug: LY2409021
  Administered orally, single dose

• Placebo Comparator: Placebo
  Administered once, orally
  Intervention: Drug: Placebo
• Experimental: 10 mg LY2409021
  10 mg LY2409021 administered once, orally
  Intervention: Drug: LY2409021
• Experimental: 22.5 mg LY2409021
  22.5 mg LY2409021 administered once, orally
  Intervention: Drug: LY2409021
• Experimental: 60 mg LY2409021
  60 mg LY2409021 administered once, orally
  Intervention: Drug: LY2409021
• Experimental: 200 mg LY2409021
  200 mg LY2409021 administered once, orally
  Intervention: Drug: LY2409021
• Experimental: 500 mg LY2409021
  500 mg LY2409021 administered once, orally
  Intervention: Drug: LY2409021

Inclusion Criteria:

• Must be a healthy male
• Have a screening body mass index (BMI) of 18.5 to 29.9 kg/m^2 inclusive
• Have a fasting blood glucose between 3.0-6.0 millimoles/liter (mmol/L) (inclusive) at screening

Exclusion Criteria:

• Are allergic to LY2409021, insulin, glucagon, somatostatin, or similar drugs
• Have a regular alcohol intake greater than 21 units/week, or are unwilling to stop alcohol as required by the study restrictions (1 unit = 360 mL of beer, or 150 mL of wine, or 45 mL of spirits)
• Are currently smokers or have used tobacco products on a regular basis in the 6 months prior to screening
• Have received any medication known to affect glucose metabolism in the 1 month before the study
• Have a significant blood disorder and/or donated blood (450 mL or more) in the last 3 months