Bananas as an Energy Source During Exercise: a Metabolomics Approach

This study has been completed.
Sponsor:
Collaborator:
Dole Food Company
Information provided by (Responsible Party):
David C. Nieman, Appalachian State University
ClinicalTrials.gov Identifier:
NCT01581190
First received: April 14, 2012
Last updated: April 18, 2012
Last verified: April 2012

April 14, 2012
April 18, 2012
September 2011
November 2011   (final data collection date for primary outcome measure)
Performance and fuel substrate utilization as measured through metabolomics [ Time Frame: Up to 6 months ] [ Designated as safety issue: No ]
Will measure shifts in metabolites following 75-km cycling while ingesting bananas or 6% carbohydrate beverage. The shift in metabolites will be assessed using GC-MS. Time frame from date of randomization until the last samples are collected and analyzed will be up to six months.
Same as current
Complete list of historical versions of study NCT01581190 on ClinicalTrials.gov Archive Site
Exercise-induced inflammation. [ Time Frame: up to 6 months ] [ Designated as safety issue: No ]
Cytokine panel (IL-6, IL-8, IL-10, TNF-alpha) before and after cycling 75-km; measured with Meso Scale Discovery in pg/ml. Time frame from randomization until the last samples are collected and analyzed will be up to six months.
Same as current
Not Provided
Not Provided
 
Bananas as an Energy Source During Exercise: a Metabolomics Approach
Comparison of Bananas and Gatorade on Performance and Exercise-induced Inflammation, Oxidative Stress, and Changes in Immune Function in Endurance Athletes

This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and metabolomics-based profiling.

Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min). Pre-, post-, and 1-h-post-exercise blood samples were analyzed for glucose, granulocyte (GR) and monocyte (MO) phagocytosis (PHAG) and oxidative burst activity, nine cytokines, F2-isoprostanes, ferric reducing ability of plasma (FRAP), and metabolic profiles using gas chromatography-mass spectrometry.

Interventional
Not Provided
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Intense Exercise
Dietary Supplement: Bananas versus 6% carbohydrate beverage
Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min).
Other Name: Gatorade
Experimental: Bananas versus 6% carbohydrate beverage
Intervention: Dietary Supplement: Bananas versus 6% carbohydrate beverage
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
14
November 2011
November 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male
  • Ages 18-45 years
  • Cyclists, road racing experience.
  • Willing to avoid the use of supplements, herbs, medications during the study.

Exclusion Criteria:

  • Female
  • Over the age of 45 years
  • No cycling racing experience
  • Using supplements and medications during the study
Male
18 Years to 45 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT01581190
11-0082
No
David C. Nieman, Appalachian State University
Appalachian State University
Dole Food Company
Principal Investigator: David C Nieman, DrPH Appalachian State University
Appalachian State University
April 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP