Vascular Subphenotypes of Lung Disease in HIV & COPD (VAST)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2012 by University of Pittsburgh.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
University of Pittsburgh Identifier:
First received: April 17, 2012
Last updated: April 19, 2012
Last verified: April 2012

April 17, 2012
April 19, 2012
January 2012
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Complete list of historical versions of study NCT01581086 on Archive Site
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Vascular Subphenotypes of Lung Disease in HIV & COPD
Identify and Characterize Populations at Risk for Developing Pulmonary Arterial Hypertension (PAH)

This study is looking for high blood pressure in the lungs (Pulmonary artery hypertension PAH) in HIV and COPD patients.

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Observational Model: Cohort
Time Perspective: Retrospective
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Retention:   Samples With DNA

Whole Blood

Non-Probability Sample

Pitt mens Study(MACS).

University of Pittsburgh HIV Clinic(PACT).

Emphysema COPD Research Center Research Registry(ECRC).

Pulmonary Artery Hypertension
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
January 2014
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Inclusion Criteria:

  • Male/Female 18-80 years of age.
  • Subject has been previously enrolled in PACT/MAC/ECRC study.
  • Must have recent ProBNP test >120pg/ml or abnormal echocardiogram (right ventricular systolic pressure >or=40mmHg) without evidence of left sided heart failure.

Exclusion Criteria:

  • Previous diagnosis of congenital heart failure.
  • If evidence of Left ventricular systolic or diastolic dysfunction, echo will be reviewed by the PI on a case by case basis.
  • Creatine clearance <60ml/min per 1.73 m2.
  • Undiagnosed chest pain or myocardial infarction, stroke or cardiovascular event within 3 months.
  • Pregnancy.
  • Subjects receiving chronic anticoagulant.
  • Inability to complete the 6 minute walk test.
18 Years to 80 Years
Contact: Tammi F Lawther, BS 412-624-8295
United States
University of Pittsburgh
University of Pittsburgh
Not Provided
Principal Investigator: Hunter C Champion, MD University of Pittsburgh
University of Pittsburgh
April 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP