Efficacy Evaluation of Traditional Chinese Medicine JITAI Combined Comprehensive Model Among Heroin Addicts After Detoxification

• The change of ASI(Addiction Severity Index) after the treatment and observation [ Time Frame: Baseline,26weeks and 52 weeks ] [ Designated as safety issue: No ]
  The investigator will use ASI to describe the addiction severity of objects and compare the different change among different groups during observation period.
• the change of drug use pattern during observation period [ Time Frame: Baseline,26weeks and 52 weeks ] [ Designated as safety issue: No ]
  The investigator will ues NHI(Nature History Interview) to describe the drug use pattern and and compare the different change among different groups during observation period.
• the change of SF-36(the MOS item short form health survey) after treatment and observation [ Time Frame: Baseline,26 weeks and 52 weeks ] [ Designated as safety issue: No ]
  The investigator will use SF-36 to describe the health status of objects and compare the different change among different groups during observation period.
• the change of SAS(Self-Rating Anxiety Scale) and SDS(Self-rating Depression Scale) during observation period [ Time Frame: Baseline ,26weeks and 52 weeks ] [ Designated as safety issue: No ]
  The investigator will use SAS and SDS to describe the anxiety status and depression status then compare the different change among different groups during observation period.

• The change of ASI after the treatment and observation [ Time Frame: 52 weeks ] [ Designated as safety issue: No ]
  We will observe the change of ASI in the treatment after week 52 and week 52 after discontinuation
• the change of NHI after treatment and observation [ Time Frame: 52 weeks ] [ Designated as safety issue: No ]
  We will observe the change of NHI in the treatment after week 52 and week 52 after discontinuation
• the change of SF-36 after treatment and observation [ Time Frame: 52 weeks ] [ Designated as safety issue: No ]
  We will observe the change of SF-36 in the treatment after week 52 and week 52 after discontinuation
• the change of SAS and SDS after treatment and observation [ Time Frame: 52 weeks ] [ Designated as safety issue: No ]
  We will observe the change of SAS and SDS in the treatment after week 52 and week 52 after discontinuation

The purpose of this research is to observe the efficacy of comprehensive treatment model to improve treatment compliance and relapse prevention.

The model include the Chinese traditional medicine JITAI combined with psychological intervention and social support for maintenance therapy after acute detoxification of heroin addicts.On the basis of the existing community management experience and community of professional anti-drug community service，The investigator will adopt the Chinese traditional medicine JITAI combined with psychological intervention and social support for maintenance therapy after acute detoxification of the community of heroin addicts.The purpose is to observe the comprehensive treatment model to improve treatment compliance and relapse prevention，then the investigator will form a new model of community humane drug treatment.

• Drug: JITAI Combined with psychological intervention
  tablet，Each tablet weight 0.4g
  Other Name: JITAI combined with psychological intervention
• Drug: Methadone
  Oral Solution，1mg/ml
  Other Name: Methadone
• Drug: Traditional Chinese Medicine JITAI
  tablet，Each tablet weight 0.4g
  Other Name: JITAI

• Experimental: JITAI combined therapy group
  The investigator will adopt JITAI combined psychological intervention and social support in Shanghai-related community.
  Intervention: Drug: JITAI Combined with psychological intervention
• Experimental: Methadone combined herapy group
  The investigator will adopt JITAI combined psychological intervention and social support in Shanghai-related community.
  Intervention: Drug: Methadone
• Experimental: JITAI therapy group
  The investigator will adopt JITAI combined social support in Shanghai-related community and outside of Shanghai.
  Intervention: Drug: Traditional Chinese Medicine JITAI

Inclusion Criteria:

• Clinical Diagnosis of The opioid dependence
• After detoxification.

Exclusion Criteria：

• Clinical Diagnosis of glaucoma and other severe mental disorder；
• serious organic disease within three months；
• can not comply with the test requirements；
• accept Hans therapy instrument；
• have tendence of suicide，self-injury and impulse；
• ECG abnormalities；
• ALT or AST greater than 5 times the upper limit of normal；
• history of epilepsy；
• Lactating or pregnant women，or women of childbearing age fails to take effective contraceptive measures；
• serious history of drug allergy or known allergy on traditional Chinese medicine JITAI；
• Study before the withdrawal less than a half-life of 5.