Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal (SchistoVAN)

This study has been completed.
Sponsor:
Collaborators:
Institut Pasteur de Lille
Université de Lille Nord de France
Région Nord-Pas de Calais, France
Center for Infection and Immunity of Lille, France
France: Centre National de la Recherche Scientifique
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
Biomedical Research Center EPLS
ClinicalTrials.gov Identifier:
NCT01553552
First received: March 12, 2012
Last updated: March 13, 2012
Last verified: March 2012

March 12, 2012
March 13, 2012
October 2011
October 2011   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT01553552 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal
Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status

SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their haemoglobinaemia.

SchistoVAN aims to study the interactions between chronic parasite infections such as schistosomiasis and the immunological and nutritional status of children. In this scope, the investigators conducted a case-control study where one group of children is infected with schistosoma haematobium and the other is not infected with this parasite.

The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.

Aims of the study:

To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.

To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.

To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)

To study prevalence of intestinal parasites such as Blastocystis hominis

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples Without DNA
Description:

Whole blood Sera Urine Stool

Non-Probability Sample

Residents of 3 villages from the Senegal Valley River, belonging to the Podor District in Saint-Louis Region in Northern Senegal: Agniam Towguel, Fanaye Diery and Niandane. Subcohort of a previous study "AnoPalAnoVac" (ClinicalTrials.gov ID: NCT01545115)

  • Schistosomiasis
  • Anemia
  • Underweight
  • Stunting
  • Intestinal Parasites
Not Provided
  • Infected by Schistosoma haematobium
  • Not infected by Schistosoma haematobium
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
99
October 2011
October 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Members of AnoPalAnoVac cohort
  • Age: between 6 and 10 years

Exclusion Criteria:

  • body temperature > 38.5 ºC
  • malaria episode
Both
6 Years to 10 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Senegal
 
NCT01553552
EPLS11-MS
Yes
Biomedical Research Center EPLS
Biomedical Research Center EPLS
  • Institut Pasteur de Lille
  • Université de Lille Nord de France
  • Région Nord-Pas de Calais, France
  • Center for Infection and Immunity of Lille, France
  • France: Centre National de la Recherche Scientifique
  • Institut National de la Santé Et de la Recherche Médicale, France
Study Chair: Emmanuel Hermann, PhD A.Pr. Biomedical Research Center EPLS
Study Director: Lobna Gaayeb, VetMed Biomedical Research Center EPLS
Principal Investigator: Modou Seck, MD Biomedical Research Center EPLS
Biomedical Research Center EPLS
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP