The Microcirculation in Acute Myocardial Infarction (Micro-AMI)

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2013 by University of Bristol
Sponsor:
Collaborators:
David Telling Charitable Trust
NIHR Cardiovascular BRU
Information provided by (Responsible Party):
Elisa McAlindon, University of Bristol
ClinicalTrials.gov Identifier:
NCT01552564
First received: March 9, 2012
Last updated: July 8, 2013
Last verified: July 2013

March 9, 2012
July 8, 2013
March 2012
Not Provided
Microvascular obstruction [ Time Frame: DAy 2-4 ] [ Designated as safety issue: No ]
Microvascular obstruction as a percentage of the left ventricle at 2-4 days.
Same as current
Complete list of historical versions of study NCT01552564 on ClinicalTrials.gov Archive Site
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The Microcirculation in Acute Myocardial Infarction (Micro-AMI)
The Microcirculation in Acute Myocardial Infarction (Micro-AMI)

This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.

Not Provided
Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample

STEMI attending Bristol Heart Institute via the primary PCI service

STEMI
  • Procedure: Index of microvascular resistance
  • Other: Cardiac magnetic resonance
  • Other: Blood markers
STEMI patients
Interventions:
  • Procedure: Index of microvascular resistance
  • Other: Cardiac magnetic resonance
  • Other: Blood markers
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
50
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Inclusion Criteria:

  • >18 years old
  • Cardiac symptoms of > 20 mins chest pain or equivalent.
  • ECG criteria consistent with STEMI (STEMI)
  • Proceeding with percutaneous angioplasty
  • Assent/ consent to the study

Exclusion Criteria:

  • Known allergy to adenosine or gadolinium
  • Chronic atrial fibrillation
  • Renal impairment with eGFR <30
  • Contraindication to angiography
  • Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner)
  • Cardiogenic shock
  • Patients with special communication needs or altered consciousness.
  • Patients who do not give assent/consent to the study
Both
18 Years and older
No
Contact: Elisa McAlindon, BMBS 01173425888 elisa.mcalindon@bristol.ac.uk
United Kingdom
 
NCT01552564
1625
Yes
Elisa McAlindon, University of Bristol
University of Bristol
  • David Telling Charitable Trust
  • NIHR Cardiovascular BRU
Not Provided
University of Bristol
July 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP