Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2012 by University of Sao Paulo.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Information provided by (Responsible Party):
Maria José Carvalho Carmona, University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT01550159
First received: February 6, 2012
Last updated: March 6, 2012
Last verified: March 2012

February 6, 2012
March 6, 2012
April 2009
February 2013   (final data collection date for primary outcome measure)
Score in Neuropsycological Tests [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
Tests for evaluation of quality of life, depressive synths and neuropsycho;logical battery to assess general mental status, learning, attention, visuospatial perception, immediate memory, operational and executive ask and recall, including processing speed. This assessment will be applied before surgery, and 3, 7,21 90 and 180 days after surgery.
Same as current
Complete list of historical versions of study NCT01550159 on ClinicalTrials.gov Archive Site
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Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery
Study of Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Graft Surgery

This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.

The systemic inflammatory response after cardiac surgery may cause damage to the central nervous system and elevated markers of brain injury in peripheral blood. This event may be potentially related to the development of postoperative cognitive dysfunction (POCD), with incidences varying from 20 to 83%.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample

Patients underwent for coronary artery bypass graft surgery.

Postoperative Cognitive Dysfunction
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
88
April 2013
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients underwent for coronary artery bypass graft surgery

Exclusion Criteria:

  • History of brain disease or dementia, other psychiatric disorders that affect cognition
  • Lack of proficiency in Portuguese language
Both
40 Years to 90 Years
No
Contact: Maria JC Carmona, M.D. 55-11-3069-6335 maria.carmona@incor.usp.br
Contact: Fernando CP Silva 55-11-3069-6335 fernandoprado@usp.br
Brazil
 
NCT01550159
1081/04
Yes
Maria José Carvalho Carmona, University of Sao Paulo
Maria José Carvalho Carmona
Fundação de Amparo à Pesquisa do Estado de São Paulo
Principal Investigator: Maria JC Carmona, MD University of Sao Paulo Medical School
University of Sao Paulo
March 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP