Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2012 by National Cancer Institute (NCI).
Recruitment status was  Active, not recruiting
Sponsor:
Collaborator:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01528956
First received: February 5, 2012
Last updated: February 11, 2012
Last verified: February 2012

February 5, 2012
February 11, 2012
February 2012
March 2012   (final data collection date for primary outcome measure)
  • Identification of genetic factors affecting adrenocortical tumors [ Designated as safety issue: No ]
  • Comprehensive catalog of altered genes in adrenocortical samples [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01528956 on ClinicalTrials.gov Archive Site
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Studying Genes in Samples From Younger Patients With Adrenocortical Tumor
Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

OBJECTIVES:

  • To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells.

OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.

Observational
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Adrenocortical Carcinoma
  • Genetic: DNA methylation analysis
  • Genetic: RNA analysis
  • Genetic: gene expression analysis
  • Genetic: nucleic acid sequencing
  • Genetic: polymorphism analysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
10
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March 2012   (final data collection date for primary outcome measure)

DISEASE CHARACTERISTICS:

  • Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
Both
up to 21 Years
No
Contact information is only displayed when the study is recruiting subjects
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NCT01528956
CDR0000724572, COG-ARAR12B1
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Peter C. Adamson, Children's Oncology Group - Group Chair Office
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Gerard Zambetti, PhD St. Jude Children's Research Hospital
National Cancer Institute (NCI)
February 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP