The Muscle Relaxation-study

• Surgical space conditions [ Time Frame: From surgical incision to last suture has been placed, an expected average of 30 minutes. ] [ Designated as safety issue: No ]
  The surgical space conditions (VAS 0-100) assessed at the time during surgery, when they were poorest
• Surgical space conditions [ Time Frame: From surgical incision to last suture has been placed, an expected average of 30 minutes. ] [ Designated as safety issue: No ]
  The average surgical space conditions (VAS 0-100 and 4-stage scale) during the procedure.
• Surgical space conditions [ Time Frame: During dissection of the gallbladder ] [ Designated as safety issue: No ]
  The surgical space conditions during dissection of the gallbladder (4-stage scale and VAS 0-100).
• Pain [ Time Frame: Preoperatively to 7 days after surgery ] [ Designated as safety issue: No ]
  Pain (shoulder, incision, deep abdominal and general) as the area under the curve from preoperatively to 7 days after surgery.
• Pain [ Time Frame: At arrival to the postanesthesia care department, 2 hours and 1 day after surgery ] [ Designated as safety issue: No ]
  Pain (shoulder, incision, deeop abdominal and general) at arrival to the postanesthesia care department, 2 hours and 1 day after surgery.
• Normal functional level [ Time Frame: from the day of surgery to re-establishing normal functional level - an expected average of 7 days. ] [ Designated as safety issue: No ]
  Numer of days before re-establing normal functional level
• Surgical procedures at low pneumoperitoneum [ Time Frame: From surgical incision to last suture has been placed, an expected average of 30 minutes. ] [ Designated as safety issue: No ]
  Number of procedures which can be done with pneumoperitoneum 8 mmHg
• Duration of surgery [ Time Frame: From surgical incision to last suture has been placed. ] [ Designated as safety issue: No ]
  Duration of surgery
• Duration of anesthesia [ Time Frame: From induction of anesthesia to patient ready to leave the operating theatre ] [ Designated as safety issue: No ]
  Duration of anesthesia
• Consumption of analgesics [ Time Frame: The first 24 hours after surgery ] [ Designated as safety issue: No ]
  Consumption of analgesics during the first 24 hours after surgery
• Nausea and vomiting [ Time Frame: The first 24 hours after surgery ] [ Designated as safety issue: No ]
  The incidence of nausea and vomiting during the first 24 hours after surgery
• anti-emetics [ Time Frame: During the first 24 hours after surgery ] [ Designated as safety issue: No ]
  Use of anti-emetics during the first 24 hours after surgery

The purpose of this investigation is to compare the surgical conditions during laparoscopic cholecystectomy at a low intra-abdominal pressure with deep or moderate muscle relaxation.

The primary hypothesis is that surgical conditions during laparoscopic cholecystectomy are better with deep muscle relaxation than moderate muscle relaxation.

The purpose of this investigation is to compare the surgical conditions with two degrees of neuromuscular blockade in patients who have laparoscopic cholecystectomy done with pneumoperitoneum 8 mmHg.

• Drug: Rocuronium
  Intravenous use: 0.3 mg/kg before intubation and 0,7 mg after intubation followed by infusion with 0,3-0,4 mg/kg/h
  Other Name: Esmeron
• Drug: Rocuronium
  Intravenous use: 0,3 mg/kg followed by NaCl-infusion
  Other Name: Esmeron

• Active Comparator: Deep neuromuscular blockade
  Intervention: Drug: Rocuronium
• Placebo Comparator: Moderate neuromuscular blockade
  Intervention: Drug: Rocuronium

Inclusion Criteria:

• Patients older than 18 years
• Scheduled for elective laparoscopic cholecystectomy
• Can read and understand danish
• Women must be post-menopausal, sterilized or use safe contraception in the form of a coil or oral anti-contraceptives

Exclusion Criteria:

• Known allergy to medications that are included in the project
• Presence of severe renal disease, neuromuscular disease, reduced liver function
• Nursing or pregnant
• Indication for crash induction
• For fertile women: Missing negative pregnancy-test