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Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

This study has been completed.
Sponsor:
Collaborator:
United Kingdom Ministry of Defence
Information provided by (Responsible Party):
QinetiQ Ltd
ClinicalTrials.gov Identifier:
NCT01505348
First received: January 4, 2012
Last updated: NA
Last verified: January 2012
History: No changes posted

January 4, 2012
January 4, 2012
July 2007
March 2008   (final data collection date for primary outcome measure)
Change in C-terminal telopeptide region of collagen type 1 (B-CTX) concentration from baseline [ Time Frame: At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise ] [ Designated as safety issue: No ]
B-CTX is a specific marker of bone resorption. It's circulating concentration is altered by both exercise and feeding
Same as current
No Changes Posted
Change in parathyroid hormone (PTH) concentration from baseline [ Time Frame: At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise ] [ Designated as safety issue: No ]
PTH is reported to induce both bone resorption and bone formation. It's circulating concentration is altered by both exercise and feeding.
Same as current
Not Provided
Not Provided
 
Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running
Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.

Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
  • Feeding Patterns
  • Bone Resorption
Other: Overnight fast
Overnight fast from 21:00 h
Other Name: Fasting
  • Experimental: Fasting
    Overnight fast
    Intervention: Other: Overnight fast
  • No Intervention: Feeding
    Normal breakfast
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10
March 2008
March 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • history of weight bearing exercise
  • fasting vitamin D concentration of >30 nmol•L-1 and/or a fasting parathyroid hormone (PTH) concentration of <6.9 pmol•L-1.

Exclusion Criteria:

  • smokers
  • suffered a bone fracture in the previous 12 months
  • musculoskeletal injury
  • condition/medication known to affect bone metabolism
Male
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT01505348
QQ-SP751
No
QinetiQ Ltd
QinetiQ Ltd
United Kingdom Ministry of Defence
Principal Investigator: Jonathan PR Scott, Ph.D QinetiQ Ltd
QinetiQ Ltd
January 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP