Plasma Adiponectin Level and Vascular Endothelial and Smooth Muscle Cell Function in Children With Prader-Willi Syndrome

This study has been completed.
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT01479322
First received: July 31, 2011
Last updated: November 23, 2011
Last verified: November 2011

July 31, 2011
November 23, 2011
January 2007
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Complete list of historical versions of study NCT01479322 on ClinicalTrials.gov Archive Site
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Plasma Adiponectin Level and Vascular Endothelial and Smooth Muscle Cell Function in Children With Prader-Willi Syndrome
Correlation Between Hyperghrelinemia and Carotid Artery Intima-Media Thickness in Children With Prader-Willi Syndrome

Context: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.

Objectives: To assess the significance of risk factors for future disabilities, carotid artery intima-media thickness (IMT) was measured and correlated with known atherosclerotic risk factors in 27 children with PWS and 24 age-, sex-, and body mass index (BMI)-adjusted controls.

Main outcome measures: Correlation of IMT with age, standard deviation score of BMI (BMI-SDS), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), C-reactive protein, HOMA-IR and ghrelin.

Observational
Observational Model: Case Control
Time Perspective: Prospective
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Probability Sample

The investigators studied twenty-seven children with PWS and 24 normal control subjects. The groups were adjusted for age, sex, and BMI.

  • Prader-Willi Syndrome
  • Obesity
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
51
July 2007
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Inclusion Criteria:

  • obesity with PWS

Exclusion Criteria:

  • chronic disease
Both
6 Years to 18 Years
Yes
Contact information is only displayed when the study is recruiting subjects
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NCT01479322
2006-11-056
Yes
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Samsung Medical Center
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Principal Investigator: Dong-Kyu Jin, M.D Samsung Medical Center, Sungkyunkwan University School of Medicine
Samsung Medical Center
November 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP