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The Effect of Physical Activity on the Brain

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
German Federal Ministry of Education and Research
Information provided by (Responsible Party):
University Hospital Muenster
ClinicalTrials.gov Identifier:
NCT01475396
First received: November 7, 2011
Last updated: June 18, 2012
Last verified: June 2012
History of Changes

November 7, 2011
June 18, 2012
March 2006
March 2012   (final data collection date for primary outcome measure)
  • Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  • Change of delayed memory scores in #of words in a Verbal learning task after 6 months of intervention/control condition [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  • Change of performance in ms in a reaction time task after 6 months of intervention/control condition [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  • Change of relative regional grey matter volumes in % measured by T1-weighted MRI after 6 months of intervention/control condition [ Time Frame: 6 months ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT01475396 on ClinicalTrials.gov Archive Site
  • Change of physical measurements (ECG)/fitness assessments (lactate) after 6 months of intervention/control condition [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  • Change of BDNF blood serum levels in ng/dl after 6 months of intervention/control condition [ Time Frame: 6 months ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
The Effect of Physical Activity on the Brain
Clinical Study on the Effect of Physical Activity on Cognition and Memory in the Elderly

Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the aging brain. Therefore, 50 to 80 years old healthy subjects take part in a prospective study with regular sports activity during 6 months. Cognitive functions are detected with sensitive neuropsychological outcome measures, further investigations include MRT of the head, lactat- and other physical measures as well as detailed serum profiles. As a hypothesis, enhanced physical activity is suggested to predict better cognitive performance.
Not Provided
Interventional
Phase 3
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
  • Aerobic Exercise
  • Anaerobic Exercise
  • Unchanged Condition
Behavioral: exercise
  • Experimental: Aerobic Exercise
    Intervention: Behavioral: exercise
  • Experimental: Anaerobic Exercise
    Intervention: Behavioral: exercise
  • No Intervention: Unchanged condition
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
120
December 2012
March 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • 50-80 years old
  • healthy
  • lesser activity

Exclusion Criteria:

  • regular physical activity
  • diabetes
  • stroke
  • heavy smoking, drinking,
  • BMI < 20
  • MMSE < 25
Both
50 Years to 80 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT01475396
Exercise_Neuromod
No
University Hospital Muenster
University Hospital Muenster
German Federal Ministry of Education and Research
Principal Investigator: Agnes Flooel, MD University Hospital of Muenster
Study Director: Stefan Knecht, MD University Hospital of Muenster
University Hospital Muenster
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP