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Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology
ClinicalTrials.gov Identifier:
NCT01472484
First received: November 9, 2011
Last updated: June 18, 2012
Last verified: June 2012
History of Changes

November 9, 2011
June 18, 2012
December 2011
January 2012   (final data collection date for primary outcome measure)
Shift in iron isotopic composition in blood after consumption of different bean varieties [ Time Frame: 1 month ] [ Designated as safety issue: No ]
Shift in iron isotopic composition in blood after consumption of different bean varieties [ Time Frame: 6 month ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT01472484 on ClinicalTrials.gov Archive Site
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Impact of Bean Polyphenols and Phytic Acid on Iron Absorption
A Stable Iron Isotope Study to Investigate the Impact of Phytic Acid and Polyphenols on Iron Absorption From Beans in Humans

Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA. These plants have normal phosphate levels, but reduced PA phosphate due to various modifications of the biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of them exhibiting reduced yield and seed germination. However, the lpa bean isolated by Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean PA concentration without any defects in terms of growth and yield.

Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the development of a variety which has the potential to improve the iron status of bean consuming populations.

The following study will evaluate the relative impact of PA and PP on iron absorption from beans by comparing iron absorption from four different bean varieties. Iron absorption from a bean with normal PA concentration and high PP concentration will be compared to iron absorption from a bean with normal PA and low PP concentration as well as to two lpa varieties, one with high and one with low PP concentration.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Bio-availability Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Blood Iron Isotope Enrichment
  • Other: 586/8x87 white
    2 x 50 g
  • Other: 586/8x87 brown
    2 x 50 g
  • Other: BAT 881
    2 x 50 g
  • Other: 586/8
    2 x 50 g
  • Experimental: lpa with high polyphenol
    Intervention: Other: 586/8x87 brown
  • Experimental: lpa with low polyphenol
    Intervention: Other: 586/8x87 white
  • Experimental: control bean with low polyphenol
    Intervention: Other: 586/8
  • Experimental: control bean with high polyphenol
    Intervention: Other: BAT 881
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
January 2012
January 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Non-pregnant, non-lactating women
  • Between 18 and 40 years
  • Below 65kg

Exclusion Criteria:

  • Metabolic, chronic and gastro-intestinal disease
  • Long-term medication
  • Blood donation within 6 month before the study
Female
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Switzerland
 
NCT01472484
lpa_586/8X87
No
Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology
Swiss Federal Institute of Technology
Not Provided
Principal Investigator: Richard Hurrell, Prof. Dr. ETH Zürich
Swiss Federal Institute of Technology
June 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP