MRA/fMRI Study of Spontaneous Migraine

This study is currently recruiting participants.
Verified August 2012 by Glostrup University Hospital, Copenhagen
Sponsor:
Collaborator:
Leiden University Medical Center
Information provided by (Responsible Party):
Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen
ClinicalTrials.gov Identifier:
NCT01471314
First received: November 10, 2011
Last updated: August 28, 2012
Last verified: August 2012

November 10, 2011
August 28, 2012
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Complete list of historical versions of study NCT01471314 on ClinicalTrials.gov Archive Site
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MRA/fMRI Study of Spontaneous Migraine
Functional MRI and MR Angiography Used in Spontaneous Migraine

The purpose of this study is to examine migraineurs during spontaneous migraine attacks without aura, using high resolution magnetic resonance imaging (MRI), to study following:

  • Changes in resting state blood-oxygenation-level-dependent-signal (BOLD-signal) using functional MRI (fMRI).
  • Changes in circumferences of intra- and extracranial arteries using MR-angiography (MRA).
  • Changes in regional and global cerebral blood flow (CBF) using the arterial spin labeling (ASL) method.

Moreover to perform diffusion tensor imaging (DTI) scans during spontaneous migraine attacks.

The migraine specific drug sumatriptan will be given to relieve pain and the effect will be registered using MRA and fMRI if possible.

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Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
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Probability Sample

Migraine without aura

Headache Versus Non-headache Day
Behavioral: Headache day versus non-headache day
Spontaneous migraine
Intervention: Behavioral: Headache day versus non-headache day
Amin FM, Asghar MS, Hougaard A, Hansen AE, Larsen VA, de Koning PJ, Larsson HB, Olesen J, Ashina M. Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol. 2013 May;12(5):454-61. doi: 10.1016/S1474-4422(13)70067-X. Epub 2013 Apr 9.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
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Inclusion Criteria:

  • Migraine without aura according to IHS criteria.

Exclusion Criteria:

  • Other primary headaches.
  • Tension-type headache more than 5 days/month.
  • Use of anti-pain medication before the scanning on the examination day.
  • Pregnant or nursing women.
  • Contraindication for MR scan.
  • Anamnestic or clinical signs of cardiovascular or cerebrovascular disease, unregulated psychiatric disease or drug misuse.
  • Other clinical conditions assessed by the examining doctor.
Both
18 Years to 60 Years
No
Contact: Faisal Amin, MD, PhD student +4538633066 famoam01@regionh.dk
Denmark
 
NCT01471314
H-C-2008-089
Yes
Faisal Mohammad Amin, Glostrup University Hospital, Copenhagen
Glostrup University Hospital, Copenhagen
Leiden University Medical Center
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Glostrup University Hospital, Copenhagen
August 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP