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Event Related Potentials in Borderline Personality Disorder and Major Depression

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2011 by State University of New York - Upstate Medical University.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Syracuse University
Information provided by (Responsible Party):
Amruther G Ramamurthy, State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:
NCT01469663
First received: October 26, 2010
Last updated: November 9, 2011
Last verified: November 2011

October 26, 2010
November 9, 2011
July 2011
March 2013   (final data collection date for primary outcome measure)
  • Error related negativity amplitude [ Time Frame: on day 1 and then 4 weeks (average) later ] [ Designated as safety issue: No ]
    electroencephalogram amplitude of the error related negativity
  • N2 amplitude [ Time Frame: on day 1 and then 4 weeks (average) later ] [ Designated as safety issue: No ]
    electroencephalogram amplitude of N2 wave
Same as current
Complete list of historical versions of study NCT01469663 on ClinicalTrials.gov Archive Site
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Event Related Potentials in Borderline Personality Disorder and Major Depression
Event Related Potentials in Borderline Personality Disorder and Major Depression

This study examines whether depression in people with borderline personality disorder is different than depression in people without borderline personality disorder.

Unlike people who have depression alone (i.e. without borderline personality disorder), people with borderline personality disorder have depressions that often do not improve with medications. This makes treating depression much more challenging in someone with borderline personality disorder than without borderline personality disorder.

Borderline personality disorderis associated with difficulty in understanding and communicating feelings. Impaired emotion processing may reflect dysfunction of an area of the brain, the anterior cingulate.

Depression is associated with changes in anterior cingulate activity. The investigators believe that when borderline personality disorder is present with depression, brain activity changes in the anterior cingulate will not be the same as in depressed patients without borderline personality disorder.

An electroencephalogram records brain electrical activity. In this study, the investigators will measure electroencephalogram indices reflecting anterior cingulate activity.

HYPOTHESIS: In this study, the investigators predict that when borderline personality is present with depression, electroencephalogram indices of anterior cingulate activity will be different from when depression is present alone (without borderline personality). This could help to explain why people with borderline personality have depressions that are harder to treat than depressions in people without borderline personality.

The investigators also predict that electroencephalogram indices of the anterior cingulate will reflect emotional processing ability, as measured by validated questionnaires.

Not Provided
Observational
Time Perspective: Cross-Sectional
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Non-Probability Sample

Females between age 18 to 45 recruited from staff (healthy controls) or from Upstate Medical University primary care outpatients, psychiatry outpatients, psychiatry inpatients

  • Borderline Personality Disorder
  • Major Depression
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  • Healthy Control
    Healthy participants without borderline personality or depression
  • Major Depression, No Borderline Personality Disorder
    With major depression and no borderline personality
  • Major Depression + Borderline Personality Disorder
    With major depression and borderline personality disorder
  • No Major Depression, Borderline Personality Disorder
    With no major depression, but with borderline personality disorder
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
40
March 2013
March 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • age between 18 and 45
  • female
  • noncontrols diagnosis: major depression &/or borderline personality disorder
  • Control participants should have neither major depression or borderline pers.
  • meet Structured Controlled Interview for DSM - II cut off scores
  • meet Beck Depression Inventory (BDI)cut off scores
  • meet Borderline Evaluation of Severity Over Time(BEST) cut off scores.

Exclusion Criteria:

  • based on having none of the below diagnoses from patient history, prior clinical records and based on MINI Plus International Neuropsychiatry Interview
  • schizophrenia
  • psychosis
  • Attention Deficit Hyperactivity Disorder
  • Obsessive Compulsive Disorder
  • bipolar disorder
  • mental retardation
  • dementia
  • CNS disease
  • Post-Traumatic Stress Disorder in non-borderline personality disorder groups
  • Recreational drug or alcohol use in the past week.
Female
18 Years to 45 Years
Yes
Contact: Amruthur G Ramamurthy, MD 315 464 5668 ramamurg@upstate.edu
Contact: Robert Gregory, MD 315 464 3169 gregoryr@upstate.edu
United States
 
NCT01469663
5910
No
Amruther G Ramamurthy, State University of New York - Upstate Medical University
State University of New York - Upstate Medical University
Syracuse University
Principal Investigator: Amruthur Ramamurthy, MD State University of New York - Upstate Medical University
State University of New York - Upstate Medical University
November 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP