VASO-AM :Impact of Oral Appliance Therapy on Endothelial Function in Obstructive Sleep Apnea

This study is currently recruiting participants.
Verified August 2011 by University Hospital, Angers
Sponsor:
Information provided by:
University Hospital, Angers
ClinicalTrials.gov Identifier:
NCT01426607
First received: June 28, 2011
Last updated: August 30, 2011
Last verified: August 2011

June 28, 2011
August 30, 2011
March 2011
March 2014   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT01426607 on ClinicalTrials.gov Archive Site
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VASO-AM :Impact of Oral Appliance Therapy on Endothelial Function in Obstructive Sleep Apnea
VASO-AM :Impact of Oral Appliance Therapy on Endothelial Function in Obstructive Sleep Apnea

This is a randomized controlled study evaluating the impact of 2 months of oral appliance therapy on endothelial function in patients with severe obstructive sleep apnea syndrome intolerant to continuous positive airway pressure (CPAP) therapy.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Obstructive Sleep Apnea Syndrome
Device: AMO
  • Experimental: AMO
    Adjustable mandibular repositioning appliance
    Intervention: Device: AMO
  • Placebo Comparator: placebo
    placebo device in upper jaw
    Intervention: Device: AMO
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
150
March 2014
March 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • AHI > 30
  • Intolerance to CPAP therapy
  • Signed informed consent

Exclusion Criteria:

  • Epworth sleepiness scale > 16/24
  • Severe cardiac and/or respiratory disease
  • BMI>32 kg/m2
  • Dental contraindication to oral appliance
Both
18 Years to 70 Years
No
Contact: Frédéric Gagnadoux, MD PhD (0)241353695 ext 0033 frgagnadoux@chu-angers.fr
France
 
NCT01426607
PHRC 2010-06
Yes
Not Provided
University Hospital, Angers
Not Provided
Not Provided
University Hospital, Angers
August 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP