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Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

This study is currently recruiting participants.
Verified March 2013 by University of Texas Southwestern Medical Center
Sponsor:
Information provided by (Responsible Party):
University of Texas Southwestern Medical Center
ClinicalTrials.gov Identifier:
NCT01421784
First received: August 10, 2011
Last updated: March 23, 2013
Last verified: March 2013
History of Changes

August 10, 2011
March 23, 2013
September 2011
December 2013   (final data collection date for primary outcome measure)
To measure time series of MRI imaging by the b-SSFP sequence. [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]
To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.
Same as current
Complete list of historical versions of study NCT01421784 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors
Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.

Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be acquired. MR acquisition will be performed without extrinsically administered contrast, using a balanced turbo field echo (TFE) sequence and commercially available coils.
Interventional
Not Provided
Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Lung Cancer
Other: cine MRI
Rapid Cine-MRI for Monitoring Moving and Deforming Tumors
Procedure
Rapid Cine-MRI
Intervention: Other: cine MRI
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
40
December 2014
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using radiotherapy will be eligible for this study.
  • Any types and amounts of prior therapy will be allowed for this study.
  • Subjects must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions.
  • Ability to understand and the willingness to sign a written informed consent document.
  • Able to tolerate supine position
  • ECOG performance status of 3 or less

Exclusion Criteria:

  • MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers
  • Women who are pregnant or trying to get pregnant
  • Pain in supine position
Both
18 Years and older
No
Contact: Amit Sawant, Ph.D 214-645-8525
Contact: Jean Wu, MSN 214-645-8525
United States
 
NCT01421784
STU 042011-034
Yes
University of Texas Southwestern Medical Center
University of Texas Southwestern Medical Center
Not Provided
Principal Investigator: Amit Sawant, Ph.D. UT Southwestern Medical Center
University of Texas Southwestern Medical Center
March 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP